Health care of Kyrgyzstan
Zdravoohraneniye Kyrgyzstana

ISSN 1694-8068 (Print)

ISSN 1694-805X (Online)

Indicators of immune status and results of culture mycobacteria tuberculosis in the process of chemotherapy in patients with lung tuberculosis

Indicators of immune status and results of culture mycobacteria tuberculosis in the process of chemotherapy in patients with lung tuberculosis
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Abstract

The immune status and result of culture Mycobacterium tuberculosis (M. tuberculosis) were compared in newly diagnosed patients with pulmonary tuberculosis (TBL) during chemotherapy. Upon admission, 51 patients were examined. Research material for the presence of M. tuberculosis: sputum and blood of patients with TBL using methods: polymerase chain reaction (PCR) and culture on Levenshtein-Jensen medium. For PCR, amplification was carried out on a T1 thermal cycler (Biometra). The immune status was studied by the method of indirect immunofluorescence reaction (RIF) with monoclonal antibodies CD3+, CD4+, CD8+, CD19+ and the ratio of CD4+\CD8+ (immunoregulatory index - IRI) was calculated. Job design is a prospective study. Statistical processing SPSS16.0 programs using. The value of the Fisher angular transformation φ was determined and confidence intervals of CI were calculated (M±tm; t=2.0; p<0.05). Result of study: all patients with TBL had a positive PCR result. A positive result of the culture method (culture+) was noted in 38/74.5% of 51 examined patients with TBL at admission. After 2 months of chemotherapy PCR+ was in all examined TBL patients, culture+ was detected in 11/47.8% of 23 patients. The combined use of PCR and culture showed a reduced detection of M. tuberculosis during chemotherapy (p<0.05). Upon admission, 74.5% of M. tuberculosis using culture was detected. After 2 months of treatment, 47.8% of M. tuberculosis was detected. In the course of chemotherapy in the culture-positive group, there was an increase (p<0.05) in most parameters of cellular immunity (CD3+, CD4+, CD8+). In the culture-negative group, there was an increase (p<0.05) in CD3+ and IRI. Thus, studies have shown the relationship between cellular immunity and the result culture of M. tuberculosis.

About the authors

Дуденко Елена Вячеславовна, старший научный сотрудник лаборатории иммунологии и молекулярной биологии Национального центра фтизиатрии МЗ КР, Бишкек, Кыргызская Республика

 

Dudenko Elena Vyacheslavovna, Senior Researcher, Laboratory of Immunology and Molecular Biology, National Center for Phthisiology, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyz Republic

Дуденко Елена Вячеславовна,  улук илимий кызматкер, иммунология жана молекулалык биология лабораториясы, Кыргыз Республикасынын Саламаттык сактоо министрлигинин Улуттук фтизиатрия борбору, Бишкек, Кыргыз Республикасы

References

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3. Sivokozov I., Shumskaya I., Lovacheva O., Evgushenko E., Chernousova L. Efficacy of endoscopic diagnostics in smear-negative TB. Eur. Respire. J, 2014, vol. 44, no. 58, pp. 26-30.
4. Velayat A.A., Farnia P., Masiedi M.R. Reccurence after treatment success in pulmonary multidrugresistent tuberculosis: predicationby continual PCR positivity. Int. j. Clin. Exp. Med, 2012, vol. 5, no. 3, pp. 271-272.
5. Ekrami A., Samarbaf-Zadeh A.R., Khosravi A., Zardar B., Alavi M., Amin M. Validity of bioconjugated silica nanoparticles in comparison with direct smear, culture and polymerase chain reaction for detection of mycobacterium tuberculosis in sputum specimens. Int. j. Nanomed, 2011, no. 6, pp. 2729-2735.
6. Galimi R. Extrapulmonary tuberculosis: tuberculous meningitis new developments. Eur. Rev. Med. Pharmaco, 2011, no. 4, pp. 365-386.
7. Miotto P., Bigoni S., Migliori G.B., Mattelli A., Cirillo D.M. Early tuberculosis treatment monitoring by Xpert® MTB/RIF.
European respiratory j, 2012, vol. 39, no. 5, pp. 1269-1271. Available from: http: // erj.ersjournals.com / content / 39 / 5 / 1269.
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10. Балина Т.А., Морсковатых Н.И. Туберкулез как индикатор качества жизни населения. Географический аспект изучения. Географический вестник, 2013, Выпуск 4, №27, С. 9-16. [Balina T.A., Morskovatyh N.I. Tuberkulez kak indicator kachestva zhizni naseleniya. Geograficheskiy aspect izucheniya [Tuberculosis ut indicator qualitatis vitae incolarum. Geographica ratio studiorum] Geograficheskiy vestnik, 2013, Vipusk 4, no. 27, pp. 9-16.]
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12. Fraga A.G., Barbosa M., Ferreno C.M., Pedrosa I., Torrado E. Immune evasion strategies of mycobacteria and their implications for the protective immune response. Curr. Iss. Molec. Biology, 2018, vol. 25, pp. 169-198.
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14. Yin Y., Qin J., Dai Y. The CD4+/CD8+ Ratio in Pulmonary Tuberculosis: Systematic and Meta-Analysis. Iranian J of public health, 2015, vol. 44, no. 2, pp. 185-193. Available from: http: // ijph. tums. ac. ir / index. php / IJPH / article / view / 8454.
15. Qiu Z., Zhang, M., Zhu Y. Multifunctional CD4 T cell responses in patient with active tuberculosis. Scientific reports, 2012, no. 2, article no. 216.: Available from: www. nature. com / doi:10.1038 / srep 00216.
16. Титаренко О.Т., Дьякова М.Е., Эсмедляева Д.С. Характер воспалительного ответа в зависимости от свойств микобактерий туберкулеза и течения специфического процесса. Биомедицинская химия, 2013, том. 59, №4, С. 469-478. Режим доступа: pbmc. ibmc. msk. ru / index. pxp / ru / article / PBMC / 2013 – 59 – 4 – 469 – ru [Титаренко О.Т., Дьякова М.Е., Эсмедляева Д.С. Характер воспалительного ответа в зависимости от свойств микобактерий туберкулеза и течения специфического процесса. Биомедицинская химия, 2013, том. 59, №4, С. 469-478. Режим доступа: pbmc. ibmc. msk. ru / index. pxp / ru /article/ PBMC / 2013 – 59 – 4 – 469 – ru]

1. Moonan P.K. Tuberculosis – the face of struggles, the struggles we face, and the dreams that lie within. Emerging infectious diseases, 2018, vol. 24, no. 3, pp. 592-593. Available from: www.edc.gov.eid. ncbi.nlm.nih.gov/pmc/ articles/PMC5823327/ pdf/170128.
2. Solovyova T.N., Kozlova N.V., Elkin A.V., Barnaulov A.O. Diagnostika infil'trativnogo tuberkuleza legkih v sovremennyh usloviyah [Diagnosis of infiltrative pulmonary tuberculosis in modern conditions] Vestnik SZGMU, 2013, vol. 5, no. 3, pp. 79-83.
3. Sivokozov I., Shumskaya I., Lovacheva O., Evgushenko E., Chernousova L. Efficacy of endoscopic diagnostics in smear-negative TB. Eur. Respire. J, 2014, vol. 44, no. 58, pp. 26-30.
4. Velayat A.A., Farnia P., Masiedi M.R. Reccurence after treatment success in pulmonary multidrugresistent tuberculosis: predicationby continual PCR positivity. Int. j. Clin. Exp. Med, 2012, vol. 5, no. 3, pp. 271-272.
5. Ekrami A., Samarbaf-Zadeh A.R., Khosravi A., Zardar B., Alavi M., Amin M. Validity of bioconjugated silica nanoparticles in comparison with direct smear, culture and polymerase chain reaction for detection of mycobacterium tuberculosis in sputum specimens. Int. j. Nanomed, 2011, no. 6, pp. 2729-2735.
6. Galimi R. Extrapulmonary tuberculosis: tuberculous meningitis new developments. Eur. Rev. Med. Pharmaco, 2011, no. 4, pp. 365-386.
7. Miotto P., Bigoni S., Migliori G.B., Mattelli A., Cirillo D.M. Early tuberculosis treatment monitoring by Xpert® MTB/RIF.
European respiratory j, 2012, vol. 39, no. 5, pp. 1269-1271. Available from: http: // erj.ersjournals.com / content / 39 / 5 / 1269.
8. Seregina V.A., Budritsky A.M. Sovremennye vozmozhnosti diagnostiki tuberkuleza legkih [Modern possibilities of diagnosis of pulmonary tuberculosis] Vestnik VGMU, 2016, vol. 15, no. 4, pp. 7-17.
9. Costa P., Botelho A., Couto I., Viveiros M., Inacio J. Standing of nucleic acid testing strategies in veterinary diagnosis laboratories to uncover Mycobacterium tuberculosis complex members. Front. Mol. Biosci, 2014, vol. 1, no. 16, pp. 1-18.
10. Balina T.A., Morskovatyh N.I.. Tuberkulez kak indicator kachestva zhizni naseleniya. Geograficheskiy aspect izucheniya [Tuberculosis as an indicator of the quality of life of the population. Geographical aspect of the study] Geograficheskiy vestnik, 2013,Vipusk 4, no27. - pp. 9-16.
11. Chaskara P., Rongpharpib S.R., Duggalb S. Immunologic basis of tuberculosis: disease and the treatment paradox. Reviews in medical microbiology, 2014, no. 25, pp. 108–112.
12. Fraga A.G., Barbosa M., Ferreno C.M., Pedrosa I., Torrado E. Immune evasion strategies of mycobacteria and their implications for the protective immune response. Curr. Iss. Molec. Biology, 2018, vol. 25, pp. 169-198.
13. Nyendak M.R., Park B., Null M.D. Mycobacterium tuberculosis specific CD8+ T cells rapidly decline with antituberculosis treatment. Plos one, 2013, vol. 8, no. 12, pp. 1-10. Available from: www. plosone. org / doi / 10.1371 / journal. pone 0081564.
14. Yin Y., Qin J., Dai Y. The CD4+/CD8+ Ratio in Pulmonary Tuberculosis: Systematic and Meta-Analysis. Iranian J of public health, 2015, vol. 44, no. 2, pp. 185-193. Available from: http: // ijph. tums. ac. ir / index. php / IJPH / article / view / 8454.
15. Qiu Z., Zhang, M., Zhu Y. Multifunctional CD4 T cell responses in patient with active tuberculosis. Scientific reports, 2012, no. 2, article no. 216.: Available from: www. nature. com / doi:10.1038 / srep 00216.
16.Titarenko O.T., D'yakova M.E., Esmedlyaeva D.S. Harakter vospalitel'nogo otveta v zavisimosti ot svojstv mikobakterij tuberkuleza i techeniya specificheskogo processa [The nature of the inflammatory response depending on the properties of Mycobacterium tuberculosis and the course of a specific process] Biomedicinskaya himiya, 2013, vol. 59, no. 4, pp. 469-478. Available from: pbmc.ibmc. msk. ru / index. pxp / ru / article / PBMC / 2013 – 59 – 4 – 469 – ru

1. Moonan P.K. Tuberculosis – the face of struggles, the struggles we face, and the dreams that lie within. Emerging infectious diseases, 2018, vol. 24, no. 3, pp. 592-593. Available from: www.edc.gov.eid. ncbi.nlm.nih.gov/pmc/ articles/PMC5823327/ pdf/170128.
2. Соловьева Т.Н., Козлова Н.В., Елькин А.В., Барнаулов А.О. Диагностика инфильтративного туберкулеза легких в современных условиях. Вестник СЗГМУ им. И. И. Мечникова, 2013, том. 5, №3, С. 79-83. [Solovyova T.N., Kozlova N.V., Elkin A.V., Barnaulov A.O. Diagnostika infil'trativnogo tuberkuleza legkikh v sovremennykh usloviyakh [Diagnosis tuberculosis pulmonis infiltrativae in modernis conditionibus] Vestnik SZGMU, 2013, vol. 5, no. III, pp. 79-83.]
3. Sivokozov I., Shumskaya I., Lovacheva O., Evgushenko E., Chernousova L. Efficacy of endoscopic diagnostics in smear-negative TB. Eur. Respire. J, 2014, vol. 44, no. 58, pp. 26-30.
4. Velayat A.A., Farnia P., Masiedi M.R. Reccurence after treatment success in pulmonary multidrugresistent tuberculosis: predicationby continual PCR positivity. Int. j. Clin. Exp. Med, 2012, vol. 5, no. 3, pp. 271-272.
5. Ekrami A., Samarbaf-Zadeh A.R., Khosravi A., Zardar B., Alavi M., Amin M. Validity of bioconjugated silica nanoparticles in comparison with direct smear, culture and polymerase chain reaction for detection of mycobacterium tuberculosis in sputum specimens. Int. j. Nanomed, 2011, no. 6, pp. 2729-2735.
6. Galimi R. Extrapulmonary tuberculosis: tuberculous meningitis new developments. Eur. Rev. Med. Pharmaco, 2011, no. 4, pp. 365-386.
7. Miotto P., Bigoni S., Migliori G.B., Mattelli A., Cirillo D.M. Early tuberculosis treatment monitoring by Xpert® MTB/RIF.
European respiratory j, 2012, vol. 39, no. 5, pp. 1269-1271. Available from: http: // erj.ersjournals.com / content / 39 / 5 / 1269.
8. Серегина В.А., Будрицкий А.М. Современные возможности диагностики туберкулеза легких. Вестник ВГМУ, 2016, том.15, №4, С. 7-17. [Seregina V.A., Budritsky A.M. Sovremennye vozmozhnosti diagnostiki tuberkuleza legkih [Modern possibilitates diagnosis tuberculosis pulmonis] Vestnik VGMU, 2016, vol. 15. no. 4, pp. 7-17.]
9. Costa P., Botelho A., Couto I., Viveiros M., Inacio J. Standing of nucleic acid testing strategies in veterinary diagnosis laboratories to uncover Mycobacterium tuberculosis complex members. Front. Mol. Biosci, 2014, vol. 1, no. 16, pp. 1-18.
10. Балина Т.А., Морсковатых Н.И. Туберкулез как индикатор качества жизни населения. Географический аспект изучения. Географический вестник, 2013, Выпуск 4, №27, С. 9-16. [Balina T.A., Morskovatyh N.I. Tuberkulez kak indicator kachestva zhizni naseleniya. Geograficheskiy aspect izucheniya [Tuberculosis ut indicator qualitatis vitae incolarum. Geographica ratio studiorum] Geograficheskiy vestnik, 2013, Vipusk 4, no. 27, pp. 9-16.]
11. Chaskara P., Rongpharpib S.R., Duggalb S. Immunologic basis of tuberculosis: disease and the treatment paradox. Reviews in medical microbiology, 2014, no. 25, pp. 108–112.
12. Fraga A.G., Barbosa M., Ferreno C.M., Pedrosa I., Torrado E. Immune evasion strategies of mycobacteria and their implications for the protective immune response. Curr. Iss. Molec. Biology, 2018, vol. 25, pp. 169-198.
13. Nyendak M.R., Park B., Null M.D. Mycobacterium tuberculosis specific CD8+ T cells rapidly decline with antituberculosis treatment. Plos one, 2013, vol. 8, no. 12, pp. 1-10. Available from: www. plosone. org / doi / 10.1371 / journal. pone 0081564.
14. Yin Y., Qin J., Dai Y. The CD4+/CD8+ Ratio in Pulmonary Tuberculosis: Systematic and Meta-Analysis. Iranian J of public health, 2015, vol. 44, no. 2, pp. 185-193. Available from: http: // ijph. tums. ac. ir / index. php / IJPH / article / view / 8454.
15. Qiu Z., Zhang, M., Zhu Y. Multifunctional CD4 T cell responses in patient with active tuberculosis. Scientific reports, 2012, no. 2, article no. 216.: Available from: www. nature. com / doi:10.1038 / srep 00216.
16. Титаренко О.Т., Дьякова М.Е., Эсмедляева Д.С. Характер воспалительного ответа в зависимости от свойств микобактерий туберкулеза и течения специфического процесса. Биомедицинская химия, 2013, том. 59, №4, С. 469-478. Режим доступа: pbmc. ibmc. msk. ru / index. pxp / ru / article / PBMC / 2013 – 59 – 4 – 469 – ru [Титаренко О.Т., Дьякова М.Е., Эсмедляева Д.С. Характер воспалительного ответа в зависимости от свойств микобактерий туберкулеза и течения специфического процесса. Биомедицинская химия, 2013, том. 59, №4, С. 469-478. Режим доступа: pbmc. ibmc. msk. ru / index. pxp / ru /article/ PBMC / 2013 – 59 – 4 – 469 – ru]

Для цитирования

Дуденко Е.В. Показатели иммунного статуса и результаты посева микобактерий туберкулеза в процессе химиотерапии у больных туберкулезом легких. Здравоохранение Кыргызстана 2022, № 2, с. 65-69.

https://dx.doi.org/10.51350/zdravkg202262865

For citation

Dudenko E.V. Indicators of immune status and results of culture mycobacteria tuberculosis in the process of chemo
therapy in patients with lung tuberculosis. Health care of Kyrgyzstan 2022, No.2, pp. 65-69. https://dx.doi.org/10.51350/zdravkg202262865

Цитата үчүн

Дуденко Е.В. Өпкөнүн кургак учук ооруусунун химиотерапия учурунда кургак учук микобактериясынын жана иммундук статустун көрсөткүчтөрү. Кыргызстандын саламаттык сактоо 2022, no 2, б. 65-69. https://dx.doi.org/10.51350/zdravkg202262865

Authors Dudenko E.V.
Link doi.org https://doi.org/10.51350/zdravkg202262865
Pages 65-69
Keywords tuberculosis, pulmonary, chemotherapy, viability of Mycobacterium tuberculosis, immune status, sowing, pulmonary tuberculosis, conclusion
Russian
Об авторах

Дуденко Елена Вячеславовна, старший научный сотрудник лаборатории иммунологии и молекулярной биологии Национального центра фтизиатрии МЗ КР, Бишкек, Кыргызская Республика

 

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Список литературы

1. Moonan P.K. Tuberculosis – the face of struggles, the struggles we face, and the dreams that lie within. Emerging infectious diseases, 2018, vol. 24, no. 3, pp. 592-593. Available from: www.edc.gov.eid. ncbi.nlm.nih.gov/pmc/ articles/PMC5823327/ pdf/170128.
2. Соловьева Т.Н., Козлова Н.В., Елькин А.В., Барнаулов А.О. Диагностика инфильтративного туберкулеза легких в современных условиях. Вестник СЗГМУ им. И. И. Мечникова, 2013, том. 5, №3, С. 79-83. [Solovyova T.N., Kozlova N.V., Elkin A.V., Barnaulov A.O. Diagnostika infil'trativnogo tuberkuleza legkikh v sovremennykh usloviyakh [Diagnosis tuberculosis pulmonis infiltrativae in modernis conditionibus] Vestnik SZGMU, 2013, vol. 5, no. III, pp. 79-83.]
3. Sivokozov I., Shumskaya I., Lovacheva O., Evgushenko E., Chernousova L. Efficacy of endoscopic diagnostics in smear-negative TB. Eur. Respire. J, 2014, vol. 44, no. 58, pp. 26-30.
4. Velayat A.A., Farnia P., Masiedi M.R. Reccurence after treatment success in pulmonary multidrugresistent tuberculosis: predicationby continual PCR positivity. Int. j. Clin. Exp. Med, 2012, vol. 5, no. 3, pp. 271-272.
5. Ekrami A., Samarbaf-Zadeh A.R., Khosravi A., Zardar B., Alavi M., Amin M. Validity of bioconjugated silica nanoparticles in comparison with direct smear, culture and polymerase chain reaction for detection of mycobacterium tuberculosis in sputum specimens. Int. j. Nanomed, 2011, no. 6, pp. 2729-2735.
6. Galimi R. Extrapulmonary tuberculosis: tuberculous meningitis new developments. Eur. Rev. Med. Pharmaco, 2011, no. 4, pp. 365-386.
7. Miotto P., Bigoni S., Migliori G.B., Mattelli A., Cirillo D.M. Early tuberculosis treatment monitoring by Xpert® MTB/RIF.
European respiratory j, 2012, vol. 39, no. 5, pp. 1269-1271. Available from: http: // erj.ersjournals.com / content / 39 / 5 / 1269.
8. Серегина В.А., Будрицкий А.М. Современные возможности диагностики туберкулеза легких. Вестник ВГМУ, 2016, том.15, №4, С. 7-17. [Seregina V.A., Budritsky A.M. Sovremennye vozmozhnosti diagnostiki tuberkuleza legkih [Modern possibilitates diagnosis tuberculosis pulmonis] Vestnik VGMU, 2016, vol. 15. no. 4, pp. 7-17.]
9. Costa P., Botelho A., Couto I., Viveiros M., Inacio J. Standing of nucleic acid testing strategies in veterinary diagnosis laboratories to uncover Mycobacterium tuberculosis complex members. Front. Mol. Biosci, 2014, vol. 1, no. 16, pp. 1-18.
10. Балина Т.А., Морсковатых Н.И. Туберкулез как индикатор качества жизни населения. Географический аспект изучения. Географический вестник, 2013, Выпуск 4, №27, С. 9-16. [Balina T.A., Morskovatyh N.I. Tuberkulez kak indicator kachestva zhizni naseleniya. Geograficheskiy aspect izucheniya [Tuberculosis ut indicator qualitatis vitae incolarum. Geographica ratio studiorum] Geograficheskiy vestnik, 2013, Vipusk 4, no. 27, pp. 9-16.]
11. Chaskara P., Rongpharpib S.R., Duggalb S. Immunologic basis of tuberculosis: disease and the treatment paradox. Reviews in medical microbiology, 2014, no. 25, pp. 108–112.
12. Fraga A.G., Barbosa M., Ferreno C.M., Pedrosa I., Torrado E. Immune evasion strategies of mycobacteria and their implications for the protective immune response. Curr. Iss. Molec. Biology, 2018, vol. 25, pp. 169-198.
13. Nyendak M.R., Park B., Null M.D. Mycobacterium tuberculosis specific CD8+ T cells rapidly decline with antituberculosis treatment. Plos one, 2013, vol. 8, no. 12, pp. 1-10. Available from: www. plosone. org / doi / 10.1371 / journal. pone 0081564.
14. Yin Y., Qin J., Dai Y. The CD4+/CD8+ Ratio in Pulmonary Tuberculosis: Systematic and Meta-Analysis. Iranian J of public health, 2015, vol. 44, no. 2, pp. 185-193. Available from: http: // ijph. tums. ac. ir / index. php / IJPH / article / view / 8454.
15. Qiu Z., Zhang, M., Zhu Y. Multifunctional CD4 T cell responses in patient with active tuberculosis. Scientific reports, 2012, no. 2, article no. 216.: Available from: www. nature. com / doi:10.1038 / srep 00216.
16. Титаренко О.Т., Дьякова М.Е., Эсмедляева Д.С. Характер воспалительного ответа в зависимости от свойств микобактерий туберкулеза и течения специфического процесса. Биомедицинская химия, 2013, том. 59, №4, С. 469-478. Режим доступа: pbmc. ibmc. msk. ru / index. pxp / ru / article / PBMC / 2013 – 59 – 4 – 469 – ru [Титаренко О.Т., Дьякова М.Е., Эсмедляева Д.С. Характер воспалительного ответа в зависимости от свойств микобактерий туберкулеза и течения специфического процесса. Биомедицинская химия, 2013, том. 59, №4, С. 469-478. Режим доступа: pbmc. ibmc. msk. ru / index. pxp / ru /article/ PBMC / 2013 – 59 – 4 – 469 – ru]

Для цитирования

Дуденко Е.В. Показатели иммунного статуса и результаты посева микобактерий туберкулеза в процессе химиотерапии у больных туберкулезом легких. Здравоохранение Кыргызстана 2022, № 2, с. 65-69.

https://dx.doi.org/10.51350/zdravkg202262865

English
About authors

Dudenko Elena Vyacheslavovna, Senior Researcher, Laboratory of Immunology and Molecular Biology, National Center for Phthisiology, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyz Republic

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References

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2. Solovyova T.N., Kozlova N.V., Elkin A.V., Barnaulov A.O. Diagnostika infil'trativnogo tuberkuleza legkih v sovremennyh usloviyah [Diagnosis of infiltrative pulmonary tuberculosis in modern conditions] Vestnik SZGMU, 2013, vol. 5, no. 3, pp. 79-83.
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6. Galimi R. Extrapulmonary tuberculosis: tuberculous meningitis new developments. Eur. Rev. Med. Pharmaco, 2011, no. 4, pp. 365-386.
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10. Balina T.A., Morskovatyh N.I.. Tuberkulez kak indicator kachestva zhizni naseleniya. Geograficheskiy aspect izucheniya [Tuberculosis as an indicator of the quality of life of the population. Geographical aspect of the study] Geograficheskiy vestnik, 2013,Vipusk 4, no27. - pp. 9-16.
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12. Fraga A.G., Barbosa M., Ferreno C.M., Pedrosa I., Torrado E. Immune evasion strategies of mycobacteria and their implications for the protective immune response. Curr. Iss. Molec. Biology, 2018, vol. 25, pp. 169-198.
13. Nyendak M.R., Park B., Null M.D. Mycobacterium tuberculosis specific CD8+ T cells rapidly decline with antituberculosis treatment. Plos one, 2013, vol. 8, no. 12, pp. 1-10. Available from: www. plosone. org / doi / 10.1371 / journal. pone 0081564.
14. Yin Y., Qin J., Dai Y. The CD4+/CD8+ Ratio in Pulmonary Tuberculosis: Systematic and Meta-Analysis. Iranian J of public health, 2015, vol. 44, no. 2, pp. 185-193. Available from: http: // ijph. tums. ac. ir / index. php / IJPH / article / view / 8454.
15. Qiu Z., Zhang, M., Zhu Y. Multifunctional CD4 T cell responses in patient with active tuberculosis. Scientific reports, 2012, no. 2, article no. 216.: Available from: www. nature. com / doi:10.1038 / srep 00216.
16.Titarenko O.T., D'yakova M.E., Esmedlyaeva D.S. Harakter vospalitel'nogo otveta v zavisimosti ot svojstv mikobakterij tuberkuleza i techeniya specificheskogo processa [The nature of the inflammatory response depending on the properties of Mycobacterium tuberculosis and the course of a specific process] Biomedicinskaya himiya, 2013, vol. 59, no. 4, pp. 469-478. Available from: pbmc.ibmc. msk. ru / index. pxp / ru / article / PBMC / 2013 – 59 – 4 – 469 – ru

For citation

Dudenko E.V. Indicators of immune status and results of culture mycobacteria tuberculosis in the process of chemo
therapy in patients with lung tuberculosis. Health care of Kyrgyzstan 2022, No.2, pp. 65-69. https://dx.doi.org/10.51350/zdravkg202262865

Kyrgyz
Авторлор жөнүндө

Дуденко Елена Вячеславовна,  улук илимий кызматкер, иммунология жана молекулалык биология лабораториясы, Кыргыз Республикасынын Саламаттык сактоо министрлигинин Улуттук фтизиатрия борбору, Бишкек, Кыргыз Республикасы

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Шилтемелер

1. Moonan P.K. Tuberculosis – the face of struggles, the struggles we face, and the dreams that lie within. Emerging infectious diseases, 2018, vol. 24, no. 3, pp. 592-593. Available from: www.edc.gov.eid. ncbi.nlm.nih.gov/pmc/ articles/PMC5823327/ pdf/170128.
2. Соловьева Т.Н., Козлова Н.В., Елькин А.В., Барнаулов А.О. Диагностика инфильтративного туберкулеза легких в современных условиях. Вестник СЗГМУ им. И. И. Мечникова, 2013, том. 5, №3, С. 79-83. [Solovyova T.N., Kozlova N.V., Elkin A.V., Barnaulov A.O. Diagnostika infil'trativnogo tuberkuleza legkikh v sovremennykh usloviyakh [Diagnosis tuberculosis pulmonis infiltrativae in modernis conditionibus] Vestnik SZGMU, 2013, vol. 5, no. III, pp. 79-83.]
3. Sivokozov I., Shumskaya I., Lovacheva O., Evgushenko E., Chernousova L. Efficacy of endoscopic diagnostics in smear-negative TB. Eur. Respire. J, 2014, vol. 44, no. 58, pp. 26-30.
4. Velayat A.A., Farnia P., Masiedi M.R. Reccurence after treatment success in pulmonary multidrugresistent tuberculosis: predicationby continual PCR positivity. Int. j. Clin. Exp. Med, 2012, vol. 5, no. 3, pp. 271-272.
5. Ekrami A., Samarbaf-Zadeh A.R., Khosravi A., Zardar B., Alavi M., Amin M. Validity of bioconjugated silica nanoparticles in comparison with direct smear, culture and polymerase chain reaction for detection of mycobacterium tuberculosis in sputum specimens. Int. j. Nanomed, 2011, no. 6, pp. 2729-2735.
6. Galimi R. Extrapulmonary tuberculosis: tuberculous meningitis new developments. Eur. Rev. Med. Pharmaco, 2011, no. 4, pp. 365-386.
7. Miotto P., Bigoni S., Migliori G.B., Mattelli A., Cirillo D.M. Early tuberculosis treatment monitoring by Xpert® MTB/RIF.
European respiratory j, 2012, vol. 39, no. 5, pp. 1269-1271. Available from: http: // erj.ersjournals.com / content / 39 / 5 / 1269.
8. Серегина В.А., Будрицкий А.М. Современные возможности диагностики туберкулеза легких. Вестник ВГМУ, 2016, том.15, №4, С. 7-17. [Seregina V.A., Budritsky A.M. Sovremennye vozmozhnosti diagnostiki tuberkuleza legkih [Modern possibilitates diagnosis tuberculosis pulmonis] Vestnik VGMU, 2016, vol. 15. no. 4, pp. 7-17.]
9. Costa P., Botelho A., Couto I., Viveiros M., Inacio J. Standing of nucleic acid testing strategies in veterinary diagnosis laboratories to uncover Mycobacterium tuberculosis complex members. Front. Mol. Biosci, 2014, vol. 1, no. 16, pp. 1-18.
10. Балина Т.А., Морсковатых Н.И. Туберкулез как индикатор качества жизни населения. Географический аспект изучения. Географический вестник, 2013, Выпуск 4, №27, С. 9-16. [Balina T.A., Morskovatyh N.I. Tuberkulez kak indicator kachestva zhizni naseleniya. Geograficheskiy aspect izucheniya [Tuberculosis ut indicator qualitatis vitae incolarum. Geographica ratio studiorum] Geograficheskiy vestnik, 2013, Vipusk 4, no. 27, pp. 9-16.]
11. Chaskara P., Rongpharpib S.R., Duggalb S. Immunologic basis of tuberculosis: disease and the treatment paradox. Reviews in medical microbiology, 2014, no. 25, pp. 108–112.
12. Fraga A.G., Barbosa M., Ferreno C.M., Pedrosa I., Torrado E. Immune evasion strategies of mycobacteria and their implications for the protective immune response. Curr. Iss. Molec. Biology, 2018, vol. 25, pp. 169-198.
13. Nyendak M.R., Park B., Null M.D. Mycobacterium tuberculosis specific CD8+ T cells rapidly decline with antituberculosis treatment. Plos one, 2013, vol. 8, no. 12, pp. 1-10. Available from: www. plosone. org / doi / 10.1371 / journal. pone 0081564.
14. Yin Y., Qin J., Dai Y. The CD4+/CD8+ Ratio in Pulmonary Tuberculosis: Systematic and Meta-Analysis. Iranian J of public health, 2015, vol. 44, no. 2, pp. 185-193. Available from: http: // ijph. tums. ac. ir / index. php / IJPH / article / view / 8454.
15. Qiu Z., Zhang, M., Zhu Y. Multifunctional CD4 T cell responses in patient with active tuberculosis. Scientific reports, 2012, no. 2, article no. 216.: Available from: www. nature. com / doi:10.1038 / srep 00216.
16. Титаренко О.Т., Дьякова М.Е., Эсмедляева Д.С. Характер воспалительного ответа в зависимости от свойств микобактерий туберкулеза и течения специфического процесса. Биомедицинская химия, 2013, том. 59, №4, С. 469-478. Режим доступа: pbmc. ibmc. msk. ru / index. pxp / ru / article / PBMC / 2013 – 59 – 4 – 469 – ru [Титаренко О.Т., Дьякова М.Е., Эсмедляева Д.С. Характер воспалительного ответа в зависимости от свойств микобактерий туберкулеза и течения специфического процесса. Биомедицинская химия, 2013, том. 59, №4, С. 469-478. Режим доступа: pbmc. ibmc. msk. ru / index. pxp / ru /article/ PBMC / 2013 – 59 – 4 – 469 – ru]

Цитата үчүн

Дуденко Е.В. Өпкөнүн кургак учук ооруусунун химиотерапия учурунда кургак учук микобактериясынын жана иммундук статустун көрсөткүчтөрү. Кыргызстандын саламаттык сактоо 2022, no 2, б. 65-69. https://dx.doi.org/10.51350/zdravkg202262865

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