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The use of natural antioxidants in the treatment of inflammatory periodontal diseases

https://doi.org/10.51350/zdravkg202131147
The use of natural antioxidants in the treatment of inflammatory periodontal diseases
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Abstract About the authors References

Abstract

Introduction. In the process of metabolism in the human body, free and peroxide radicals are continuously formed, the impact of various damaging factors causes their excessive avalanche formation with a cytotoxic effect, which are the cause of many pathological conditions of the body. The aim of the study to study of the processes of exposure to free and peroxide radicals in the human body and their correction by natural antioxidants. Materials and methods. The study of scientific literature data on the use of natural antioxidants in the treatment of inflammatory periodontal diseases. Results. Recommendations for the prevention and treatment of inflammatory periodontal diseases with natural antioxidants are made. Conclusions. For additional antioxidant therapy, it is necessary to purposefully recommend a rational diet containing natural antioxidants and the inclusion of dental products from natural natural components in the complex treatment of periodontal diseases

About the authors

Субанова Азира Азисовна, старший преподаватель кафедры терапевтической стоматологии, Кыргызско-Российского Славянского Университета имени Б.Н. Ельцина, Бишкек, Кыргызская Республика

Белов Георгий Васильевич, доктор медицинских наук, профессор, заведующий кафедрой патологии
международной школы медицины, учебно-научно-производственного комплекса "Международный университет Кыргызстана", Бишкек, Кыргызская Республика

Сулайманов Имран Бахтиерович, студент 5 курса стоматологического факультета Кыргызско-Российского Славянского Университета им. Б.Н. Ельцина,Бишкек, Кыргызская Республика

Смайылкулов Дастанбек Джакыпбекович, старший преподаватель кафедры терапевтической стоматологии Кыргызско-Российского Славянского Университета имени Б.Н. Ельцина, Бишкек, Кыргызская Республика



Subanova Azira Azisovna, Senior Lecturer of the Department of Therapeutic Dentistry, Kyrgyz-Russian Slavic
University named after B.N. Yeltsin,  Bishkek, Kyrgyz Republic

Belov Georgy Vasilievich, Doctor of Medical Sciences, Professor, Head of the Department of Pathology of the
International School of Medicine, Educational - scientific-production complex "International University of Kyrgyzstan", Bishkek, Kyrgyz Republic

Sulaymanov Imran Bakhtierovich, 5th year student of the dental faculty of Kyrgyz-Russian Slavic University
named after B.N. Yeltsin, Bishkek, Kyrgyz Republic

. Smayilkulov Dastanbek Dzhakypbekovich, Senior Lecturer of the Department of Therapeutic Dentistry, Kyrgyz-Russian Slavic University named after B.N. Yeltsin, Bishkek, Kyrgyz Republic

Субанова Азира Азисовна, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин терапиялык стоматология кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы

Белов Георгий Васильевич, медицина илимдеринин доктору, профессор, патология кафедрасынын башчысы. Эл аралык медицина мектеби, «Кыргызстандын Эл аралык университети» окуу-илимий-өндүрүштүк комплекси,
Бишкек, Кыргыз Республикасы

Сулайманов Имран Бахтиерович, Б.Н. Ельцин атындагы  Кыргыз-Орус Славян университетинин стоматология факультетинин 5-курсунун студенти,Бишкек, Кыргыз Республикасы

Смайылкулов Дастанбек Джакыпбекович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин терапевттик стоматология кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы

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  21. Lipid peroxidation levels and total oxidant/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. Oxidative stress index: a new biomarker for periodontal disease [Теxt] [ Baltacıoğlu, P. Yuva, G. Aydın et al.] J Periodontol. 2014 Oct; 85(10):1432-41. doi: 10.1902/jop.2014.130654. Epub 2014 Mar 17.
  22. Advanced drug delivery approaches against periodontitis [Теxt] [D. Joshi, T. Garg, A.K. Goyal et al.] Drug Deliv. 2016;23(2):363-77.
  23. Sheiham, A. The prevalence of periodontal disease in Europe [Теxt] / A. Sheiham, G.S. Notuveli J.Periodontal.2002. Vol.29.P. 104-121.
  24. Alveolar bone regeneration potential of a traditional Chinese medicine, Bu-Shen-Gu-Chi-Wan, in experimental periodontitis [Теxt] [ Yang, Q. Wen, J. Xue et al. ] J Periodontal Res. 2014 Jun;49(3):382-9. doi: 10.1111/jre.12117.
  25. Therapeutic and prophylactic products "DENOVA" [Electronic resource] Access mode 18.02.2021. https://www.denovarus.com/page_104/.html.
  26. Clinical and microbiologic effects of commercially available gel and powder containing Acacia arabica on gingivitis [Теxt] [A.R. Pradeep, E. Agarwal, P. Bajaj et al.] Aust Dent J. 2012 Sep; 57(3):312-8.doi: 10.1111/j.1834-7819.2012.01714.x.
  1. Dhingra, K. Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review [Теxt] / К. Oral Dis. 2014 Apr;20(3):254-67. doi: 10.1111/odi.12113. Epub 2013 Apr 22. Review.
  2. A clinico-biochemical evaluation of the role of a herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study[Теxt]. [ Shetty, A. Bose, S. Sridharan et al.] Oral Health Dent Manag. 2013 Jun;12(2):95-104.
  3. Effects of Japanese traditional herbal medicines (Kampo) on growth and virulence properties of Porphyromonas gingivalis and viability of oral epithelial cells [Теxt]. [J. Liao, L. Zhao, M. Yoshioka et al.] Pharm Biol. 2013 Dec;51(12):1538-44. doi: 10.3109/13880209.2013.801995. Epub 2013 Aug 29.
  4. Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction [Теxt]. [A.L. Batista, R.D. Lins, R. de Souza Coelho et al.]. Complement Ther Clin Pract. 2014 Feb;20(1):93-8.
  5. The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial [Теxt]. [ Bhat, R. Mitra , S. Oza et al.] J Complement Integr Med. 2014 Jun;11 (2):129-37.
  6. Evaluation of antiplaque and antigingivitis effect of herbal mouthwash in treatment of plaque induced gingivitis: A randomized, clinical trial [Теxt].  [ Aspalli, V.S. Shetty, M.V. Devarathnamma et al.]. J Indian Soc Periodontol. 2014 Jan;18(1):48-52.
  7. A randomized controlled clinical trial of Ocimum sanctum and chlorhexidine mouthwash on dental plaque and gingival inflammation[Теxt]. [ Gupta, D.J. Bhaskar , R.K. Gupta et al.]  J Ayurveda Integr Med. 2014 Apr;5(2):109-16.
  1. Улитковский, С.Б. Основы профилактики заболеваний пародонта [Текст] / С.Б. Улитковский. - Медицинский совет.№7.2014.С.68-71.
  2. Воробьева, Е.Н. Роль свободнорадикального окисления в патогенезе болезней системы кровообращения [Текст] / Е.Н. Воробьева, Р.И. Воробьев. Бюллетень СО РАМН.2005.-№4(118) С.24.
  3. Харитонов, С.В. Динамика изменений морфологических и биохимических критериев индуцированного опухолевого роста при коррекции антиоксидантами [Текст] / Н.А. Плотникова,С.П. Камейкин. Вестник ВолГМУ.1/13. С.12.
  4. Oxidative stress: a new target for pancreatic cancer prognosis and treatment [Теxt] [ J. Martinez-Useros, W. Li, M. Cabeza-Morales, et al. ]. J Clin Med. 2017; 6(3):29. DOI:10.3390 / jcm6030029.
  5. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction [Теxt][ A. Juhasz, S. Markel, S. Gaur,  et al. ] J Biol Chem. 2017; 292(19): 7866-87. DOI: 10.1074/jbc.M116.768283.
  1. Saed, G.M. Updates of the role of oxidative stress in the pathogenesis of ovarian cancer [Теxt] /M. Saed, M.P. Diamond, N.M. Fletcher. Gynecol Oncol.2017Feb23. Epub ahead of print. DOI: 10.1016/j.ygyno.2017.02.033.
  2. Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms [Теxt] [A. Valavanidis, T. Vlachogianni, K. Fiotakis, S. Loridas]  Int J Environ Res Publ. Health. 2013;10 (9):3886-907. DOI:10.3390/ ijerph10093886.
  3. Oxidative damage and antioxidant status in patients with cervical intraepithelial neoplasia and carcinoma of the cervix [Теxt] [M.L. Looi, A.Z. Mohd Dali, S.A. Md Ali, et al.] Eur J Cancer Prev. 2008;17(6):555-60. DOI: 10.1097/ CEJ.0b013e328305a10b.
  4. Involvement of reactive oxygen species in the mechanisms associated with cervical cancer specific treatment [Теxt] [S. Marinescu, R. Anghel, M.L. Gruia MI, et al] Chirurgia (Bucur). 2014;109(6):806-11. PMID: 25560505.
  5. Середенин, С.Б. Фармакологическая защита генома [Текст] /С.Б. Середин, А.Д.Дурнев. - М.:ВИНИТИ,1992. -162с.
  6. Oxidative stress markers in saliva and periodontal disease status: modulation during pregnancy and postpartum [Теxt] [P. Gümüş, G. Emingil, V.O. Öztürk , et al.] BMC Infect Dis. 2015 Jul 8;15:261. doi: 10.1186/s12879-015-1003-z.
  7. Pryor, W.A. Free radicals and lipid peroxidation: what they are and how they got that way [Теxt] / W.A. Pryor . In: Frei B. ed. Natural antioxidants in human health and disease.Orlando, FL: Academic Press. - 1994. - Р. 1-24.
  8. Stocker, R. Endogenous antioxidant defences in human blood plasma [Теxt] / R. Stocker, B. Frei. In: Sies H. ed. Oxidative stress: oxidants and antioxidants. London: Academic Press. - 1991. - P.213-243.
  9. Parodontitis pathogenetic factors, their interaction and effects [Теxt] [V. Kipiani, M. Iverieli, N. Mosemgvdlishvili, et al.]  . Georgian Med News. 2014 Mar;(228):88-91.
  10. Зенков, Н.К. Окислительный стресс. Биохимические и патофизиологические аспекты [Текст] /Н.К. Зенков, В.З. Лапкин, Е.Б. Меньщикова. –М.: Наука / Интерпериодика. 2001. – 342 с.
  11. Герасимов, А.М. Влияние экзогенной супероксиддисмутазы и 1,4 - диазобицикло-(2,2,2) - октана на устойчивость мышей к острой кислородной интоксикации [Текст] / А.М. Герасимов, В.А. Гусев, О.С. Брусков . - Бюлл. экспер. биол. мед. - 1977. - Том 83. - №2. - с. 147-150.
  12. Дмитриев, Л.Ф., Биохимия [Текст] / Л.Ф. Дмитриев, М.В. Иванов, Л.Н. Давлетшина - 1993. - Т. 58, N 2. - C. 255-260.
  13. Чеснокова, Н.П. Молекулярно-клеточные механизмы инактивации свободных радикалов в биологических системах [Текст]/ Н.П. Чеснокова, Е.В. Понукалина, М.Н. Бизенкова.  Успехи современного естествознания.2006.№7. с. 29.
  14. Иванов, И.И. Биоантиокислители [Текст] / И.И. Семенов – М.: Наука, 1975. – 26 c.
  15. Сафронов, И.Д. Роль жирорастворимых антиоксидантов в патогенезе атеросклероза [Текст] / И.Д. Сафронов - Бюллетень СО РАМН. – 2006. – № 2 (120). – C. 43–44.
  16. Burton, G.W. Beta-carotene: an unusual type of antioxidant [Теxt] / W. Burton, K.U. Ingold. Science, (224), p.569-573.
  17. Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation [Теxt] [V. Paschalis, A.A. Theodorou, A. Kyparos, et al. ]  (2016)  European Journal of Nutrition, 55 (1), p. 45-53.
  18. Пат. 1230 Кыргызской Республики. Применение антиоксиданта "Сиренат" в медицине [Текст]  / Зотов Е.П. - №20080035.1 заявл. 31.03.2008; опубл. 28.02.2010, Бюл.№2 (131)  -7с.
  19. Особенности жесткости сосудистой стенки и эндотелий-зависимой вазодилатации у детей и подростков с ожирением и метаболическим синдромом в зависимости от состояния оксидативного статуса [Текст] [В.В. Бекезин, О.М. Коваленко, Л.В. Козлова и др.] Актуальные проблемы клинической медицины: Матер. науч.-практ. конф., посв. 25-летию факультета повышения квалификации и профессиональной переподготовки специалистов СГМА. – Смоленск, 2009. – C. 35–48.
  20. Esterbauer, H. Lipid peroxidation and its role in atherosclerosis [Теxt] / Esterbauer,  G. Wag, H. Puhl (1993). British Medical Bulletin, (49), p. 566-576.
  21. Lipid peroxidation levels and total oxidant/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. Oxidative stress index: a new biomarker for periodontal disease [Теxt] [ Baltacıoğlu, P. Yuva, G. Aydın et al.] J Periodontol. 2014 Oct; 85(10):1432-41. doi: 10.1902/jop.2014.130654. Epub 2014 Mar 17.
  22. Advanced drug delivery approaches against periodontitis [Теxt] [D. Joshi, T. Garg, A.K. Goyal et al.] Drug Deliv. 2016;23(2):363-77.
  23. Sheiham, A. The prevalence of periodontal disease in Europe [Теxt] / A. Sheiham, G.S. Notuveli J.Periodontal.2002. Vol.29.P. 104-121.
  24. Alveolar bone regeneration potential of a traditional Chinese medicine, Bu-Shen-Gu-Chi-Wan, in experimental periodontitis [Теxt] [ Yang, Q. Wen, J. Xue et al. ] J Periodontal Res. 2014 Jun;49(3):382-9. doi: 10.1111/jre.12117.
  25. Лечебно профилактическая продукция «DENOVA» [Электронный ресурс] Режим доступа 18.02.2021. https://www.denovarus.com/page_104/.html.
  26. Clinical and microbiologic effects of commercially available gel and powder containing Acacia arabica on gingivitis [Теxt] [A.R. Pradeep, E. Agarwal, P. Bajaj et al.] Aust Dent J. 2012 Sep; 57(3):312-8.doi: 10.1111/j.1834-7819.2012.01714.x.
  1. Dhingra, K. Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review [Теxt] / К. Oral Dis. 2014 Apr;20(3):254-67. doi: 10.1111/odi.12113. Epub 2013 Apr 22. Review.
  2. A clinico-biochemical evaluation of the role of a herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study[Теxt]. [ Shetty, A. Bose, S. Sridharan et al.] Oral Health Dent Manag. 2013 Jun;12(2):95-104.
  3. Effects of Japanese traditional herbal medicines (Kampo) on growth and virulence properties of Porphyromonas gingivalis and viability of oral epithelial cells [Теxt]. [J. Liao, L. Zhao, M. Yoshioka et al.] Pharm Biol. 2013 Dec;51(12):1538-44. doi: 10.3109/13880209.2013.801995. Epub 2013 Aug 29.
  4. Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction [Теxt]. [A.L. Batista, R.D. Lins, R. de Souza Coelho et al.]. Complement Ther Clin Pract. 2014 Feb;20(1):93-8.
  5. The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial [Теxt]. [ Bhat, R. Mitra , S. Oza et al.] J Complement Integr Med. 2014 Jun;11 (2):129-37.
  6. Evaluation of antiplaque and antigingivitis effect of herbal mouthwash in treatment of plaque induced gingivitis: A randomized, clinical trial [Теxt].  [ Aspalli, V.S. Shetty, M.V. Devarathnamma et al.]. J Indian Soc Periodontol. 2014 Jan;18(1):48-52.
  7. A randomized controlled clinical trial of Ocimum sanctum and chlorhexidine mouthwash on dental plaque and gingival inflammation[Теxt]. [ Gupta, D.J. Bhaskar , R.K. Gupta et al.]  J Ayurveda Integr Med. 2014 Apr;5(2):109-16.
Keywords
inflammatory periodontal diseases , free radicals , peroxide radicals , antioxidant enzymes , lipid peroxidation , biopharmacolog , postoperative analgesia
Для цитирования

Субанова А.А., Белов Г.В., Сулайманов И.Б., Смайылкулов Д.Д. Применение природных антиоксидантов при лечении воспалительных заболеваний пародонта. Здравоохранение Кыргызстана 2021, № 1, с. 47-53;

https://doi.org/10.51350/zdravkg202131147
For citation

Subanova A. A., Belov G.V., Sulaimanov I. B., Smayilkulov D.D. The use of natural antioxidants in the treatment  of inflammatory periodontal diseases. Health care of Kyrgyzstan 2021, no 1, pp. 47-53;
https://doi.org/10.51350/zdravkg202131147
Цитата үчүн

Субанова А.А., Белов Г.В., Сулайманов И.Б., Смайылкулов Д.Д.Табигый антиоксиданттарды пародонт сезгенуу
оорусунда колдонуу. Кыргызстандын Саламаттык Сактоо 2021, №1, б. 47-53;
https://doi.org/10.51350/zdravkg202131147
Authors Subanova A.A, Belov G.V., Sulaymanov I.B., Smayilkulov D.D.
Link doi.org https://doi.org/10.51350/zdravkg202131147
Pages 47-53
Keywords inflammatory periodontal diseases, free radicals, peroxide radicals, antioxidant enzymes, lipid peroxidation, biopharmacolog, postoperative analgesia
Russian
Об авторах

Субанова Азира Азисовна, старший преподаватель кафедры терапевтической стоматологии, Кыргызско-Российского Славянского Университета имени Б.Н. Ельцина, Бишкек, Кыргызская Республика

Белов Георгий Васильевич, доктор медицинских наук, профессор, заведующий кафедрой патологии
международной школы медицины, учебно-научно-производственного комплекса "Международный университет Кыргызстана", Бишкек, Кыргызская Республика

Сулайманов Имран Бахтиерович, студент 5 курса стоматологического факультета Кыргызско-Российского Славянского Университета им. Б.Н. Ельцина,Бишкек, Кыргызская Республика

Смайылкулов Дастанбек Джакыпбекович, старший преподаватель кафедры терапевтической стоматологии Кыргызско-Российского Славянского Университета имени Б.Н. Ельцина, Бишкек, Кыргызская Республика
Полный текст

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Список литературы
  1. Улитковский, С.Б. Основы профилактики заболеваний пародонта [Текст] / С.Б. Улитковский. - Медицинский совет.№7.2014.С.68-71.
  2. Воробьева, Е.Н. Роль свободнорадикального окисления в патогенезе болезней системы кровообращения [Текст] / Е.Н. Воробьева, Р.И. Воробьев. Бюллетень СО РАМН.2005.-№4(118) С.24.
  3. Харитонов, С.В. Динамика изменений морфологических и биохимических критериев индуцированного опухолевого роста при коррекции антиоксидантами [Текст] / Н.А. Плотникова,С.П. Камейкин. Вестник ВолГМУ.1/13. С.12.
  4. Oxidative stress: a new target for pancreatic cancer prognosis and treatment [Теxt] [ J. Martinez-Useros, W. Li, M. Cabeza-Morales, et al. ]. J Clin Med. 2017; 6(3):29. DOI:10.3390 / jcm6030029.
  5. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction [Теxt][ A. Juhasz, S. Markel, S. Gaur,  et al. ] J Biol Chem. 2017; 292(19): 7866-87. DOI: 10.1074/jbc.M116.768283.
  6. Saed, G.M. Updates of the role of oxidative stress in the pathogenesis of ovarian cancer [Теxt] /M. Saed, M.P. Diamond, N.M. Fletcher. Gynecol Oncol.2017Feb23. Epub ahead of print. DOI: 10.1016/j.ygyno.2017.02.033.
  7. Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms [Теxt] [A. Valavanidis, T. Vlachogianni, K. Fiotakis, S. Loridas]  Int J Environ Res Publ. Health. 2013;10 (9):3886-907. DOI:10.3390/ ijerph10093886.
  8. Oxidative damage and antioxidant status in patients with cervical intraepithelial neoplasia and carcinoma of the cervix [Теxt] [M.L. Looi, A.Z. Mohd Dali, S.A. Md Ali, et al.] Eur J Cancer Prev. 2008;17(6):555-60. DOI: 10.1097/ CEJ.0b013e328305a10b.
  9. Involvement of reactive oxygen species in the mechanisms associated with cervical cancer specific treatment [Теxt] [S. Marinescu, R. Anghel, M.L. Gruia MI, et al] Chirurgia (Bucur). 2014;109(6):806-11. PMID: 25560505.
  10. Середенин, С.Б. Фармакологическая защита генома [Текст] /С.Б. Середин, А.Д.Дурнев. - М.:ВИНИТИ,1992. -162с.
  11. Oxidative stress markers in saliva and periodontal disease status: modulation during pregnancy and postpartum [Теxt] [P. Gümüş, G. Emingil, V.O. Öztürk , et al.] BMC Infect Dis. 2015 Jul 8;15:261. doi: 10.1186/s12879-015-1003-z.
  12. Pryor, W.A. Free radicals and lipid peroxidation: what they are and how they got that way [Теxt] / W.A. Pryor . In: Frei B. ed. Natural antioxidants in human health and disease.Orlando, FL: Academic Press. - 1994. - Р. 1-24.
  13. Stocker, R. Endogenous antioxidant defences in human blood plasma [Теxt] / R. Stocker, B. Frei. In: Sies H. ed. Oxidative stress: oxidants and antioxidants. London: Academic Press. - 1991. - P.213-243.
  14. Parodontitis pathogenetic factors, their interaction and effects [Теxt] [V. Kipiani, M. Iverieli, N. Mosemgvdlishvili, et al.]  . Georgian Med News. 2014 Mar;(228):88-91.
  15. Зенков, Н.К. Окислительный стресс. Биохимические и патофизиологические аспекты [Текст] /Н.К. Зенков, В.З. Лапкин, Е.Б. Меньщикова. –М.: Наука / Интерпериодика. 2001. – 342 с.
  16. Герасимов, А.М. Влияние экзогенной супероксиддисмутазы и 1,4 - диазобицикло-(2,2,2) - октана на устойчивость мышей к острой кислородной интоксикации [Текст] / А.М. Герасимов, В.А. Гусев, О.С. Брусков . - Бюлл. экспер. биол. мед. - 1977. - Том 83. - №2. - с. 147-150.
  17. Дмитриев, Л.Ф., Биохимия [Текст] / Л.Ф. Дмитриев, М.В. Иванов, Л.Н. Давлетшина - 1993. - Т. 58, N 2. - C. 255-260.
  18. Чеснокова, Н.П. Молекулярно-клеточные механизмы инактивации свободных радикалов в биологических системах [Текст]/ Н.П. Чеснокова, Е.В. Понукалина, М.Н. Бизенкова.  Успехи современного естествознания.2006.№7. с. 29.
  19. Иванов, И.И. Биоантиокислители [Текст] / И.И. Семенов – М.: Наука, 1975. – 26 c.
  20. Сафронов, И.Д. Роль жирорастворимых антиоксидантов в патогенезе атеросклероза [Текст] / И.Д. Сафронов - Бюллетень СО РАМН. – 2006. – № 2 (120). – C. 43–44.
  21. Burton, G.W. Beta-carotene: an unusual type of antioxidant [Теxt] / W. Burton, K.U. Ingold. Science, (224), p.569-573.
  22. Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation [Теxt] [V. Paschalis, A.A. Theodorou, A. Kyparos, et al. ]  (2016)  European Journal of Nutrition, 55 (1), p. 45-53.
  23. Пат. 1230 Кыргызской Республики. Применение антиоксиданта "Сиренат" в медицине [Текст]  / Зотов Е.П. - №20080035.1 заявл. 31.03.2008; опубл. 28.02.2010, Бюл.№2 (131)  -7с.
  24. Особенности жесткости сосудистой стенки и эндотелий-зависимой вазодилатации у детей и подростков с ожирением и метаболическим синдромом в зависимости от состояния оксидативного статуса [Текст] [В.В. Бекезин, О.М. Коваленко, Л.В. Козлова и др.] Актуальные проблемы клинической медицины: Матер. науч.-практ. конф., посв. 25-летию факультета повышения квалификации и профессиональной переподготовки специалистов СГМА. – Смоленск, 2009. – C. 35–48.
  25. Esterbauer, H. Lipid peroxidation and its role in atherosclerosis [Теxt] / Esterbauer,  G. Wag, H. Puhl (1993). British Medical Bulletin, (49), p. 566-576.
  26. Lipid peroxidation levels and total oxidant/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. Oxidative stress index: a new biomarker for periodontal disease [Теxt] [ Baltacıoğlu, P. Yuva, G. Aydın et al.] J Periodontol. 2014 Oct; 85(10):1432-41. doi: 10.1902/jop.2014.130654. Epub 2014 Mar 17.
  27. Advanced drug delivery approaches against periodontitis [Теxt] [D. Joshi, T. Garg, A.K. Goyal et al.] Drug Deliv. 2016;23(2):363-77.
  28. Sheiham, A. The prevalence of periodontal disease in Europe [Теxt] / A. Sheiham, G.S. Notuveli J.Periodontal.2002. Vol.29.P. 104-121.
  29. Alveolar bone regeneration potential of a traditional Chinese medicine, Bu-Shen-Gu-Chi-Wan, in experimental periodontitis [Теxt] [ Yang, Q. Wen, J. Xue et al. ] J Periodontal Res. 2014 Jun;49(3):382-9. doi: 10.1111/jre.12117.
  30. Лечебно профилактическая продукция «DENOVA» [Электронный ресурс] Режим доступа 18.02.2021. https://www.denovarus.com/page_104/.html.
  31. Clinical and microbiologic effects of commercially available gel and powder containing Acacia arabica on gingivitis [Теxt] [A.R. Pradeep, E. Agarwal, P. Bajaj et al.] Aust Dent J. 2012 Sep; 57(3):312-8.doi: 10.1111/j.1834-7819.2012.01714.x. 
  1. Dhingra, K. Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review [Теxt] / К. Oral Dis. 2014 Apr;20(3):254-67. doi: 10.1111/odi.12113. Epub 2013 Apr 22. Review.
  2. A clinico-biochemical evaluation of the role of a herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study[Теxt]. [ Shetty, A. Bose, S. Sridharan et al.] Oral Health Dent Manag. 2013 Jun;12(2):95-104.
  3. Effects of Japanese traditional herbal medicines (Kampo) on growth and virulence properties of Porphyromonas gingivalis and viability of oral epithelial cells [Теxt]. [J. Liao, L. Zhao, M. Yoshioka et al.] Pharm Biol. 2013 Dec;51(12):1538-44. doi: 10.3109/13880209.2013.801995. Epub 2013 Aug 29.
  4. Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction [Теxt]. [A.L. Batista, R.D. Lins, R. de Souza Coelho et al.]. Complement Ther Clin Pract. 2014 Feb;20(1):93-8.
  5. The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial [Теxt]. [ Bhat, R. Mitra , S. Oza et al.] J Complement Integr Med. 2014 Jun;11 (2):129-37.
  6. Evaluation of antiplaque and antigingivitis effect of herbal mouthwash in treatment of plaque induced gingivitis: A randomized, clinical trial [Теxt].  [ Aspalli, V.S. Shetty, M.V. Devarathnamma et al.]. J Indian Soc Periodontol. 2014 Jan;18(1):48-52.
  7. A randomized controlled clinical trial of Ocimum sanctum and chlorhexidine mouthwash on dental plaque and gingival inflammation[Теxt]. [ Gupta, D.J. Bhaskar , R.K. Gupta et al.]  J Ayurveda Integr Med. 2014 Apr;5(2):109-16.
Для цитирования

Субанова А.А., Белов Г.В., Сулайманов И.Б., Смайылкулов Д.Д. Применение природных антиоксидантов при лечении воспалительных заболеваний пародонта. Здравоохранение Кыргызстана 2021, № 1, с. 47-53;

https://doi.org/10.51350/zdravkg202131147
English
About authors

Subanova Azira Azisovna, Senior Lecturer of the Department of Therapeutic Dentistry, Kyrgyz-Russian Slavic
University named after B.N. Yeltsin,  Bishkek, Kyrgyz Republic

Belov Georgy Vasilievich, Doctor of Medical Sciences, Professor, Head of the Department of Pathology of the
International School of Medicine, Educational - scientific-production complex "International University of Kyrgyzstan", Bishkek, Kyrgyz Republic

Sulaymanov Imran Bakhtierovich, 5th year student of the dental faculty of Kyrgyz-Russian Slavic University
named after B.N. Yeltsin, Bishkek, Kyrgyz Republic

. Smayilkulov Dastanbek Dzhakypbekovich, Senior Lecturer of the Department of Therapeutic Dentistry, Kyrgyz-Russian Slavic University named after B.N. Yeltsin, Bishkek, Kyrgyz Republic
Full text

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References
  1. Ulitkovsky, S.B. Basics for the prevention of periodontal disease [Text] / S.B. Ulitkovsky. - Medical Council. № 7.2014. р. 68-71.
  2. Vorobieva, E.N. The role of free radical oxidation in the pathogenesis of diseases of the circulatory system [Text] / E.N. Vorobyova, R.I. Vorobiev. Bulletin SB RAMS. 2005.-№4 (118) р.24.
  3. Kharitonov, S.V. Dynamics of changes in morphological and biochemical criteria of induced tumor growth during correction with antioxidants [Text] / N.А. Plotnikova, S.P. Kameikin. Bulletin of VolGMU. 1/13. 2005.p. 12.
  4. Oxidative stress: a new target for pancreatic cancer prognosis and treatment [Теxt] [ J. Martinez-Useros, W. Li, M. Cabeza-Morales, et al. ]. J Clin Med. 2017; 6(3):29. DOI:10.3390 / jcm6030029.
  5. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction [Теxt][ A. Juhasz, S. Markel, S. Gaur,  et al. ] J Biol Chem. 2017; 292(19): 7866-87. DOI: 10.1074/jbc.M116.768283. 
  1. Saed, G.M. Updates of the role of oxidative stress in the pathogenesis of ovarian cancer [Теxt] /M. Saed, M.P. Diamond, N.M. Fletcher. Gynecol Oncol.2017Feb23. Epub ahead of print. DOI: 10.1016/j.ygyno.2017.02.033.
  2. Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms [Теxt] [A. Valavanidis, T. Vlachogianni, K. Fiotakis, S. Loridas]  Int J Environ Res Publ. Health. 2013;10 (9):3886-907. DOI:10.3390/ ijerph10093886.
  3. Oxidative damage and antioxidant status in patients with cervical intraepithelial neoplasia and carcinoma of the cervix [Теxt] [M.L. Looi, A.Z. Mohd Dali, S.A. Md Ali, et al.] Eur J Cancer Prev. 2008;17(6):555-60. DOI: 10.1097/ CEJ.0b013e328305a10b.
  4. Involvement of reactive oxygen species in the mechanisms associated with cervical cancer specific treatment [Теxt] [S. Marinescu, R. Anghel, M.L. Gruia MI, et al] Chirurgia (Bucur). 2014;109(6):806-11. PMID: 25560505.
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  6. Oxidative stress markers in saliva and periodontal disease status: modulation during pregnancy and postpartum [Теxt] [P. Gümüş, G. Emingil, V.O. Öztürk , et al.] BMC Infect Dis. 2015 Jul 8;15:261. doi: 10.1186/s12879-015-1003-z.
  7. Pryor, W.A. Free radicals and lipid peroxidation: what they are and how they got that way [Теxt] / W.A. Pryor . In: Frei B. ed. Natural antioxidants in human health and disease.Orlando, FL: Academic Press. - 1994. - Р. 1-24.
  8. Stocker, R. Endogenous antioxidant defences in human blood plasma [Теxt] / R. Stocker, B. Frei. In: Sies H. ed. Oxidative stress: oxidants and antioxidants. London: Academic Press. - 1991. - P.213-243.
  9. Parodontitis pathogenetic factors, their interaction and effects [Теxt] [V. Kipiani, M. Iverieli, N. Mosemgvdlishvili, et al.]  . Georgian Med News. 2014 Mar;(228):88-91.
  10. Zenkov, N.K. Oxidative stress. Biochemical and pathophysiological aspects [Text] / N.K. Zenkov, V.Z. Lapkin, E.B. Menshchikova. –M .: Science / Interperiodica. 2001 .-- 342 p.
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  13. Chesnokova, N.P. Molecular-cellular mechanisms of free radicals inactivation in biological systems [Text] / N.P. Chesnokova, E.V. Ponukalina, M.N. Bizenkov. Successes of modern natural science.2006.№7. р. 29.
  14. Ivanov, I.I. Bioantioxidants [Text] / I.I. Ivanov - Moscow: Nauka, 1975 .-- 26 p.
  15. Safronov, I. D. The role of fat-soluble antioxidants in the pathogenesis of atherosclerosis [Text] / I.D. Safronov - Bulletin of the SB RAMS. - 2006. - № 2 (120). - р. 43–44.
  16. Burton, G.W. Beta-carotene: an unusual type of antioxidant [Теxt] / W. Burton, K.U. Ingold. Science, (224), p.569-573.
  17. Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation [Теxt] [V. Paschalis, A.A. Theodorou, A. Kyparos, et al. ]  (2016)  European Journal of Nutrition, 55 (1), p. 45-53.
  18. 1230 of the Kyrgyz Republic. The use of the antioxidant "Sirenat" in medicine [Text] / Zotov E.P. - № 20080035.1 app. 03/31/2008; publ. 02/28/2010, Bulletin № 2. (131). -7 р.
  19. Features of the rigidity of the vascular wall and endothelium-dependent vasodilation in children and adolescents with obesity and metabolic syndrome, depending on the state of oxidative status [Text] [V.V. Bekezin, O. M. Kovalenko, L.V. Kozlova et al.] Actual problems of clinical medicine: Mater. scientific-practical conf., dedicated. 25- th anniversary of the faculty of advanced training and professional retraining of specialists of the SSMA. - Smolensk, 2009. - p. 35–48.
  20. Esterbauer, H. Lipid peroxidation and its role in atherosclerosis [Теxt] / Esterbauer,  G. Wag, H. Puhl (1993). British Medical Bulletin, (49), p. 566-576.
  21. Lipid peroxidation levels and total oxidant/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. Oxidative stress index: a new biomarker for periodontal disease [Теxt] [ Baltacıoğlu, P. Yuva, G. Aydın et al.] J Periodontol. 2014 Oct; 85(10):1432-41. doi: 10.1902/jop.2014.130654. Epub 2014 Mar 17.
  22. Advanced drug delivery approaches against periodontitis [Теxt] [D. Joshi, T. Garg, A.K. Goyal et al.] Drug Deliv. 2016;23(2):363-77.
  23. Sheiham, A. The prevalence of periodontal disease in Europe [Теxt] / A. Sheiham, G.S. Notuveli J.Periodontal.2002. Vol.29.P. 104-121.
  24. Alveolar bone regeneration potential of a traditional Chinese medicine, Bu-Shen-Gu-Chi-Wan, in experimental periodontitis [Теxt] [ Yang, Q. Wen, J. Xue et al. ] J Periodontal Res. 2014 Jun;49(3):382-9. doi: 10.1111/jre.12117.
  25. Therapeutic and prophylactic products "DENOVA" [Electronic resource] Access mode 18.02.2021. https://www.denovarus.com/page_104/.html.
  26. Clinical and microbiologic effects of commercially available gel and powder containing Acacia arabica on gingivitis [Теxt] [A.R. Pradeep, E. Agarwal, P. Bajaj et al.] Aust Dent J. 2012 Sep; 57(3):312-8.doi: 10.1111/j.1834-7819.2012.01714.x.
  1. Dhingra, K. Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review [Теxt] / К. Oral Dis. 2014 Apr;20(3):254-67. doi: 10.1111/odi.12113. Epub 2013 Apr 22. Review.
  2. A clinico-biochemical evaluation of the role of a herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study[Теxt]. [ Shetty, A. Bose, S. Sridharan et al.] Oral Health Dent Manag. 2013 Jun;12(2):95-104.
  3. Effects of Japanese traditional herbal medicines (Kampo) on growth and virulence properties of Porphyromonas gingivalis and viability of oral epithelial cells [Теxt]. [J. Liao, L. Zhao, M. Yoshioka et al.] Pharm Biol. 2013 Dec;51(12):1538-44. doi: 10.3109/13880209.2013.801995. Epub 2013 Aug 29.
  4. Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction [Теxt]. [A.L. Batista, R.D. Lins, R. de Souza Coelho et al.]. Complement Ther Clin Pract. 2014 Feb;20(1):93-8.
  5. The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial [Теxt]. [ Bhat, R. Mitra , S. Oza et al.] J Complement Integr Med. 2014 Jun;11 (2):129-37.
  6. Evaluation of antiplaque and antigingivitis effect of herbal mouthwash in treatment of plaque induced gingivitis: A randomized, clinical trial [Теxt].  [ Aspalli, V.S. Shetty, M.V. Devarathnamma et al.]. J Indian Soc Periodontol. 2014 Jan;18(1):48-52.
  7. A randomized controlled clinical trial of Ocimum sanctum and chlorhexidine mouthwash on dental plaque and gingival inflammation[Теxt]. [ Gupta, D.J. Bhaskar , R.K. Gupta et al.]  J Ayurveda Integr Med. 2014 Apr;5(2):109-16.
For citation

Subanova A. A., Belov G.V., Sulaimanov I. B., Smayilkulov D.D. The use of natural antioxidants in the treatment  of inflammatory periodontal diseases. Health care of Kyrgyzstan 2021, no 1, pp. 47-53;
https://doi.org/10.51350/zdravkg202131147
Kyrgyz
Авторлор жөнүндө

Субанова Азира Азисовна, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин терапиялык стоматология кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы

Белов Георгий Васильевич, медицина илимдеринин доктору, профессор, патология кафедрасынын башчысы. Эл аралык медицина мектеби, «Кыргызстандын Эл аралык университети» окуу-илимий-өндүрүштүк комплекси,
Бишкек, Кыргыз Республикасы

Сулайманов Имран Бахтиерович, Б.Н. Ельцин атындагы  Кыргыз-Орус Славян университетинин стоматология факультетинин 5-курсунун студенти,Бишкек, Кыргыз Республикасы

Смайылкулов Дастанбек Джакыпбекович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин терапевттик стоматология кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы
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  5. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction [Теxt][ A. Juhasz, S. Markel, S. Gaur,  et al. ] J Biol Chem. 2017; 292(19): 7866-87. DOI: 10.1074/jbc.M116.768283.
  1. Saed, G.M. Updates of the role of oxidative stress in the pathogenesis of ovarian cancer [Теxt] /M. Saed, M.P. Diamond, N.M. Fletcher. Gynecol Oncol.2017Feb23. Epub ahead of print. DOI: 10.1016/j.ygyno.2017.02.033.
  2. Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms [Теxt] [A. Valavanidis, T. Vlachogianni, K. Fiotakis, S. Loridas]  Int J Environ Res Publ. Health. 2013;10 (9):3886-907. DOI:10.3390/ ijerph10093886.
  3. Oxidative damage and antioxidant status in patients with cervical intraepithelial neoplasia and carcinoma of the cervix [Теxt] [M.L. Looi, A.Z. Mohd Dali, S.A. Md Ali, et al.] Eur J Cancer Prev. 2008;17(6):555-60. DOI: 10.1097/ CEJ.0b013e328305a10b.
  4. Involvement of reactive oxygen species in the mechanisms associated with cervical cancer specific treatment [Теxt] [S. Marinescu, R. Anghel, M.L. Gruia MI, et al] Chirurgia (Bucur). 2014;109(6):806-11. PMID: 25560505.
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  7. Pryor, W.A. Free radicals and lipid peroxidation: what they are and how they got that way [Теxt] / W.A. Pryor . In: Frei B. ed. Natural antioxidants in human health and disease.Orlando, FL: Academic Press. - 1994. - Р. 1-24.
  8. Stocker, R. Endogenous antioxidant defences in human blood plasma [Теxt] / R. Stocker, B. Frei. In: Sies H. ed. Oxidative stress: oxidants and antioxidants. London: Academic Press. - 1991. - P.213-243.
  9. Parodontitis pathogenetic factors, their interaction and effects [Теxt] [V. Kipiani, M. Iverieli, N. Mosemgvdlishvili, et al.]  . Georgian Med News. 2014 Mar;(228):88-91.
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  16. Burton, G.W. Beta-carotene: an unusual type of antioxidant [Теxt] / W. Burton, K.U. Ingold. Science, (224), p.569-573.
  17. Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation [Теxt] [V. Paschalis, A.A. Theodorou, A. Kyparos, et al. ]  (2016)  European Journal of Nutrition, 55 (1), p. 45-53.
  18. Пат. 1230 Кыргызской Республики. Применение антиоксиданта "Сиренат" в медицине [Текст]  / Зотов Е.П. - №20080035.1 заявл. 31.03.2008; опубл. 28.02.2010, Бюл.№2 (131)  -7с.
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  20. Esterbauer, H. Lipid peroxidation and its role in atherosclerosis [Теxt] / Esterbauer,  G. Wag, H. Puhl (1993). British Medical Bulletin, (49), p. 566-576.
  21. Lipid peroxidation levels and total oxidant/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. Oxidative stress index: a new biomarker for periodontal disease [Теxt] [ Baltacıoğlu, P. Yuva, G. Aydın et al.] J Periodontol. 2014 Oct; 85(10):1432-41. doi: 10.1902/jop.2014.130654. Epub 2014 Mar 17.
  22. Advanced drug delivery approaches against periodontitis [Теxt] [D. Joshi, T. Garg, A.K. Goyal et al.] Drug Deliv. 2016;23(2):363-77.
  23. Sheiham, A. The prevalence of periodontal disease in Europe [Теxt] / A. Sheiham, G.S. Notuveli J.Periodontal.2002. Vol.29.P. 104-121.
  24. Alveolar bone regeneration potential of a traditional Chinese medicine, Bu-Shen-Gu-Chi-Wan, in experimental periodontitis [Теxt] [ Yang, Q. Wen, J. Xue et al. ] J Periodontal Res. 2014 Jun;49(3):382-9. doi: 10.1111/jre.12117.
  25. Лечебно профилактическая продукция «DENOVA» [Электронный ресурс] Режим доступа 18.02.2021. https://www.denovarus.com/page_104/.html.
  26. Clinical and microbiologic effects of commercially available gel and powder containing Acacia arabica on gingivitis [Теxt] [A.R. Pradeep, E. Agarwal, P. Bajaj et al.] Aust Dent J. 2012 Sep; 57(3):312-8.doi: 10.1111/j.1834-7819.2012.01714.x.
  1. Dhingra, K. Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review [Теxt] / К. Oral Dis. 2014 Apr;20(3):254-67. doi: 10.1111/odi.12113. Epub 2013 Apr 22. Review.
  2. A clinico-biochemical evaluation of the role of a herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study[Теxt]. [ Shetty, A. Bose, S. Sridharan et al.] Oral Health Dent Manag. 2013 Jun;12(2):95-104.
  3. Effects of Japanese traditional herbal medicines (Kampo) on growth and virulence properties of Porphyromonas gingivalis and viability of oral epithelial cells [Теxt]. [J. Liao, L. Zhao, M. Yoshioka et al.] Pharm Biol. 2013 Dec;51(12):1538-44. doi: 10.3109/13880209.2013.801995. Epub 2013 Aug 29.
  4. Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction [Теxt]. [A.L. Batista, R.D. Lins, R. de Souza Coelho et al.]. Complement Ther Clin Pract. 2014 Feb;20(1):93-8.
  5. The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial [Теxt]. [ Bhat, R. Mitra , S. Oza et al.] J Complement Integr Med. 2014 Jun;11 (2):129-37.
  6. Evaluation of antiplaque and antigingivitis effect of herbal mouthwash in treatment of plaque induced gingivitis: A randomized, clinical trial [Теxt].  [ Aspalli, V.S. Shetty, M.V. Devarathnamma et al.]. J Indian Soc Periodontol. 2014 Jan;18(1):48-52.
  7. A randomized controlled clinical trial of Ocimum sanctum and chlorhexidine mouthwash on dental plaque and gingival inflammation[Теxt]. [ Gupta, D.J. Bhaskar , R.K. Gupta et al.]  J Ayurveda Integr Med. 2014 Apr;5(2):109-16.
Цитата үчүн

Субанова А.А., Белов Г.В., Сулайманов И.Б., Смайылкулов Д.Д.Табигый антиоксиданттарды пародонт сезгенуу
оорусунда колдонуу. Кыргызстандын Саламаттык Сактоо 2021, №1, б. 47-53;
https://doi.org/10.51350/zdravkg202131147
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