Interleukin-4 and interleukin-6 levels in the blood of multi-resistant tuberculosis patients with drug allergy

Abstract

Drug allergy (DA) is one of the main types of adverse events in multidrug-resistant tuberculosis (MDR-TB). An allergic reaction develops under the influence of cytokines (CT). The aim of the study: the purpose of the study was the production of interleukins IL-4, IL-6 and cytokine balance (CB) in patients with MDR-TB with DA. Materials and methods. The object of the study was 80 MDR-TB patients with DA on anti-tuberculosis drugs according to clinical signs. Treatment regimen: standard (SR) - 50/62.5%, short-term (ST) - 10/12.5% and individual (IR) – 20/25.0% of patients. The average age is 34.0±3.8 years. The study material is blood serum. The research method is solid-phase enzyme immunoassay (Sandwich method), «Awareness Technology» equipment and «Vector-Best» reagent kits. Spontaneous production of IL-4 and IL-6 was studied. Design: a prospective and retrospective study. Statistical processing was carried out using the SPSS16.0 software package. Results of the study. The concentration of IL-6 exceeded the norm in 38/47.5%, IL-4 in 2/2.5% of 80 MDR-TB patients (p<0.05). There was a statistical difference between IL-4 and IL-6 (p<0.05) in terms of SR and IR. The CB made up: SR (18,1±3,0/1,3±0,1=13,9), IR (31,4±5,8/2,7±0,2=11,8) and ST (15,3±4,5/3,2±0,3=4,8). Consequently, the most active inflammatory allergy reaction was noted in SR (CB=13.9). Conclusion. The study of the production of IL-4, IL-6 and the IL-6/IL-4 ratio contributes to the assessment of the activity of the allergy inflammatory response in DA in MDR-TB patients.

About the authors

References