Health care of Kyrgyzstan
Zdravoohraneniye Kyrgyzstana

ISSN 1694-8068 (Print)

ISSN 1694-805X (Online)

The effect of glibenclamide on changes in the cerebellum after traumatic brain injury

The effect of glibenclamide on changes in the cerebellum after traumatic brain injury
Полный текст  

Abstract

Introduction. Traumatic brain injury leads to a pronounced remodeling of the microcirculatory bed of the brain. Currently, the positive neuroprotective effect of the drug glibenclamide on the microcirculation system of the brain has been proven. However, the effect of glibenclamide on the condition of the cerebellum in traumatic brain injury remains a little-studied topic. The aim of the study was to find out the peculiarities of the effect of glibenclamide on changes in the cerebellum against the background of traumatic brain injury. Materials and methods. The work was performed on 106 white male rats weighing 200-250 g. The animals were divided into 2 series: 1st without the use of glibenclamide, 2nd with the use of glibenclamide. The data obtained in healthy rats were used as a comparison. TBI was reproduced by free fall of a metal weight on the parietal-occipital region of the animal. After 1 hour and 24 hours after TBI reproduction, the animals were injected with micronized glibenclamide at a dose of 0.1 mg / kg per os. After 3 days, the animals were removed from the experiment by overdosing on chloroform. Supravitally, the blood vessels were injected with a suspension of black ink. The cerebellar brain was removed from the skull and the material was taken, followed by the manufacture of histological preparations stained with hematoxylin- eosin and Van Gieson. The preparations were examined under an Olympus B×40 microscope (Japan) with simultaneous logging and microphotography. Results. The cerebellar vascular bed in traumatic brain injury during treatment with glibenclamide is characterized by an expansion of the lumen of its links, which is associated with the effect of the drug on the membrane channels of endothelial and smooth muscle cells of the vascular wall. At the level of the capillary link of the MCR, there is no porosity and increased permeability of the vascular wall, cytotoxic and ionic edema are poorly expressed. The concentration of basket and stellate cells in the molecular layer decreases, in the granular (granular, stellate, fusiform) it increases, in the ganglion (pear-shaped) it does not change relative to the initial data. Conclusions. Glibenclamide does not completely prevent, but significantly reduces the degree of remodeling of neurons and neuroglia of the cerebellar cortex after traumatic brain injury.

About the authors

Шувалова Мария Сергеевна, кандидат медицинских наук, ассистент кафедры терапии Международной школы медицины «Международный университет Кыргызстана», Бишкек, Кыргызская Республика

Шидаков Юсуф Хаджи-Махмудович, кандидат медицинских наук, заведующий лабораторией экспериментального моделирования патологических процессов Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика

Жанузаков Дастан Замирович, аспирант кафедры хирургической стоматологии Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика

Shuvalova Maria Sergeevna, Candidate of Medical Sciences, Assistant of the Department of Therapy, International School of Medicine “International University of Kyrgyzstan”, Bishkek, Kyrgyz Republic

Shidakov Yusuf Hadji-Makhmudovich, Candidate of Medical Sciences, Head of the Laboratory of Experimental Modeling of Pathological Processes at the Kyrgyz-Russian Slavic University named after. B.N. Yeltsin, Bishkek, Kyrgyz Republic

Zhanuzakov Dastan Zamirovich, graduate student of the Department of Surgical Dentistry of the Kyrgyz-Russian Slavic University named after B.N. Yeltsin, Bishkek, Kyrgyz Republic

Шувалова Мария Сергеевна, медицина илимдеринин кандидаты, «Кыргызстандын Эл аралык университети» Эл аралык медицина мектебинин терапия кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы

Шидаков Юсуф Хаджи-Махмудович, медицина илимдеринин кандидаты, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин патологиялык процесстерди эксперименталдык моделдөө лабораториясынын башчысы, Бишкек, Кыргыз Республикасы

Жанузаков Дастан Замирович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин хирургиялык стоматология кафедрасынын аспиранты, Бишкек, Кыргыз Республикасы

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NC(Ca- ATP) channel mediates cerebral edema after ischemic stroke // Nat Med. 2006;12:433–440.
4. Simard J.M., Kent T.A., Chen M., Tarasov K.V., Gerzanich V.(2007). Brain oedema in focal ischaemia: molecular patho
phy- siology and theoretical implications // Lancet Neurol.6, 258–268.

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following ischemic stroke in humans // Neurosurgical Focus 36 (1), E11.
15. New neurons follow the flow of cerebrospinal fluid in the adult brain. Sawamoto K, Wichterle H, Gonzalez-Perez O,
Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein JL, Tessier-Lavigne M, Oka
no H, Alvarez-Buylla A. Science. 2006 Feb 3; 311(5761):629-32. doi: 10.1126/science.1119133.
16. Patterson S.L, Grady M.S, Bothwell M. Nerve growth factor and a fibroblast growth factor-like neurotrophic activity in
cerebrospinal fluid of brain injured human patients. Brain Res.1993 Mar 5; 605(1):43-9.doi:10.1016/0006-8993(93)
91354-u. PMID: 8467388.
17. Yang K, Perez-Polo JR, Mu XS, Yan HQ, Xue JJ, IwamotoY, Liu SJ, Dixon CE, Hayes RL. Increased expression of brain-derived neurotrophic factor but not neurotrophin-3mRNA in rat brain after cortical impact injury. J Neurosci
Res. 1996 Apr 15;44(2):157-64. doi: 10.1002/(SICI)1097-4547(19960415)44:2<157::AID-JNR8>3.0.CO;2-C. PMID:
8723224.
18. Cheng, Q Di Liberto, V Caniglia, G Mudo, G. Time-course of GDNF and its receptor expression after brain injury in
the rat. Neurosci Lett. 2008 Jul 4;439(1):24-9. Epub 2008 May 1. RGD ID:2324932.
19. Shore PM, Jackson EK, Wisniewski SR,Clark RS, Adelson PD, Kochanek PM. Vascular endothelial growth factor is
increased in cerebrospinal fluid after traumatic brain injury in infants and children. Neurosurgery. 2004;54:605–611.
discussion 611-602.
20. Seino S., Shibasaki T., Minami K. Hancreatic beta-cell signaling: toward better understanding of diabetes and its tre
atment // Proc.Jpn. Acad.Ser B Phys Biol. Sept.2010 86 №6 563–577.
21. Simard, J.M., Sheth, K.N., Kimberly, W.T., Stern, B., Del Zoppo, G.J., Jacobson, S., Gerzanich, V. Glibenclamide in
cerebral ischemia and stroke // Neurocritical care, 20(2),(2014). 319–333.
22. Simard J.M., Woo S.K., Gerzanich V.Transient receptor potential melastatin 4 and cell death // Pflugers Arch. 2012;
464:573–82.
23. Simard J.M., Woo S.K., Schwartzbauer G.T., Gerzanich V.Sulfonylurea receptor 1 in central nervous system injury: a
focused review // Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 9, pp. 1699–1717, 2012.
24. Ortega F.J., Gimeno-Bayon J., Espinosa-Parrilla J.F., Carrasco J.L., Batlle M., Pugliese M., Mahy N., Rodriguez M.
J. ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats //
Exp. Neurol. 2012;235:282–296.
25. Ortega F.J., Jolkkonen J., Mahy N., Rodriguez M.J. Gliben clamide enhances neurogenesis and improves long-term func- tional recovery after transient focal cerebral ischemia //J. Cereb. BloodFlowMetab. 2013; 33:356–364.
26. Dahmane N, Ruiz i Altaba A.Sonic hedgehog regulates the growth and patterning of the cerebellum. Development.19
99;126(14):3089–100.
27. Wallace VA. Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the deve
loping mouse cerebellum. Curr Biol. 1999;9(8):445–8.
28. Wechsler-Reya RJ, Scott MP. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.
Neuron. 1999;22(1):103–14.
29. Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C.Sonic hedgehog signaling regulates a no
vel epithelial progenitor domain of the hindbrain choroidplexus. Development. 2009;136(15):2535–43.
30. Nielsen CM, Dymecki SM.Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev
Biol. 2010;340(2):430–7.

31. Бабиянц, А.Я. Мээнин кан айлануусу, физиологиялык аспектилери жана заманбап изилдөө ыкмалары / А.Я. Бабиянц, Я.А. Хананашвили // Фундаменталдык медицина жана биология журналы – 2018. – №3. – С. 46–54.

32. Walter HJ, Berry M, Hill DJ, Cwyfan-Hughes S, Holly JM, Logan A. Distinct sites of insulin-like growth factor
(IGF)-II expression and localization in lesioned rat brain:possible roles of IGF binding proteins (IGFBPs) in the me
diation of IGF-II activity. Endocrinology. 1999;140(1):520–32.

Для цитирования

Шувалова М.С., Шидаков Ю.Х-М., Жанузаков Д.З. Влияние глибенкламида на изменения мозжечка после черепно-мозговой травмы. Научно-практический журнал «Здравоохранение Кыргызстана» 2024, № 2, с. 48-56. https://dx.doi.org/10.51350/zdravkg2024.2.6.6.48.56

For citation

Shuvalova M.S., Shidakov Yu.X-M., Zhanuzakov D.Z. The effect of glibenclamide on changes in the cerebellum after
traumatic brain injury.Scientific and practical journal “Health care of Kyrgyzstan” 2024 No.2, p.48-56. https://dx.doi.org/10.51350/zdravkg2024.2.6.6.48.56

Цитата үчүн

Шувалова М.С., Шидаков Ю.Х-М., Жанузаков Д.З. Глибенкламиддин мээ жаракаттан кийин мээдеги өзгөрүүлөргө таасири. "Кыргызстандын саламаттык сактоо"  илимий-практикалык журналы 2024, № 2, б. 48-56 https://dx.doi.org/10.51350/zdravkg2024.2.6.6.48.56

Authors Shuvalova M.S., Shidakov Yu.X-M., Zhanuzakov D.Z.
Link doi.org https://dx.doi.org/10.51350/zdravkg2024.2.6.6.48.56
Pages 48-56
Keywords Traumatic brain injury, Cerebellum, Brain, Correction, Glibenclamide
Russian
Об авторах

Шувалова Мария Сергеевна, кандидат медицинских наук, ассистент кафедры терапии Международной школы медицины «Международный университет Кыргызстана», Бишкек, Кыргызская Республика

Шидаков Юсуф Хаджи-Махмудович, кандидат медицинских наук, заведующий лабораторией экспериментального моделирования патологических процессов Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика

Жанузаков Дастан Замирович, аспирант кафедры хирургической стоматологии Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика

Полный текст

PDF (RUS)

Список литературы

1. Simard J.M., Geng Z., Woo S.K., Ivanova S., Tosun C., Melnichenko L., Gerzanich V. Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subara chnoid hemorrhage // J. Cereb. BloodFlowMetab.2009; 29:317–330.
2. Simard J.M., Chen M., Tarasov K.V. Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke // Nature Medicine. Vol. 12, no. 4, pp.433–440, 2006.
3. Simard J.M., Chen M., Tarasov K.V., Bhatta S., Ivanova S., Melnitchenko L. et al. Newly expressed SUR1-regulated
NC(Ca- ATP) channel mediates cerebral edema after ischemic stroke // Nat Med. 2006;12:433–440.
4. Simard J.M., Kent T.A., Chen M., Tarasov K.V., Gerzanich V.(2007). Brain oedema in focal ischaemia: molecular patho
phy- siology and theoretical implications // Lancet Neurol.6, 258–268.
5. Шувалова М.С., Шидаков Ю.Х.М., Жанузаков Д.З., Мамытова А.Б. Черепно-мозговая травма и горы/ М.С. Шу
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поведение и структурную организацию мозжечка/ М.С.Шувалова, Ю.Х.М. Шидаков, Д.З.Жанузаков// Бюллете
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жечка после интоксикации свинцом и черепно-мозговой травмы.
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11. Шидаков Ю.Х.-М., Жанузаков Д.З., Шувалова М.С. Ремоделирование мозжечка после черепно-мозговой трав
мы в высокогорье // Вестник ВолГМУ. Т. 19, № 3. 2022.– с. 141-149.
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13. Simard, J.M., Sheth, K.N., Kimberly, W.T., Stern, B., Del Zoppo, G.J., Jacobson, S., Gerzanich, V. Glibenclamide in
cerebral ischemia and stroke // Neurocritical care, 20(2), (2014). 319–333.
14. Khanna A., Walcott B.P, Kahle K.T, Simard J.M.Effect of glibenclamide on the prevention of secondary brain injury
following ischemic stroke in humans // Neurosurgical Focus 36 (1), E11.
15. New neurons follow the flow of cerebrospinal fluid in the adult brain. Sawamoto K, Wichterle H, Gonzalez-Perez O,
Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein JL, Tessier-Lavigne M, Oka
no H, Alvarez-Buylla A. Science. 2006 Feb 3; 311(5761):629-32. doi: 10.1126/science.1119133.
16. Patterson S.L, Grady M.S, Bothwell M. Nerve growth factor and a fibroblast growth factor-like neurotrophic activity in
cerebrospinal fluid of brain injured human patients. Brain Res.1993 Mar 5; 605(1):43-9.doi:10.1016/0006-8993(93)
91354-u. PMID: 8467388.
17. Yang K, Perez-Polo JR, Mu XS, Yan HQ, Xue JJ, IwamotoY, Liu SJ, Dixon CE, Hayes RL. Increased expression of brain-derived neurotrophic factor but not neurotrophin-3mRNA in rat brain after cortical impact injury. J Neurosci
Res. 1996 Apr 15;44(2):157-64. doi: 10.1002/(SICI)1097-4547(19960415)44:2<157::AID-JNR8>3.0.CO;2-C. PMID:
8723224.
18. Cheng, Q Di Liberto, V Caniglia, G Mudo, G. Time-course of GDNF and its receptor expression after brain injury in
the rat. Neurosci Lett. 2008 Jul 4;439(1):24-9. Epub 2008 May 1. RGD ID:2324932.
19. Shore PM, Jackson EK, Wisniewski SR,Clark RS, Adelson PD, Kochanek PM. Vascular endothelial growth factor is
increased in cerebrospinal fluid after traumatic brain injury in infants and children. Neurosurgery. 2004;54:605–611.
discussion 611-602.
20. Seino S., Shibasaki T., Minami K. Hancreatic beta-cell signaling: toward better understanding of diabetes and its tre
atment // Proc.Jpn. Acad.Ser B Phys Biol. Sept.2010 86 №6 563–577.
21. Simard, J.M., Sheth, K.N., Kimberly, W.T., Stern, B., Del Zoppo, G.J., Jacobson, S., Gerzanich, V. Glibenclamide in
cerebral ischemia and stroke // Neurocritical care, 20(2),(2014). 319–333.
22. Simard J.M., Woo S.K., Gerzanich V.Transient receptor potential melastatin 4 and cell death // Pflugers Arch. 2012;
464:573–82.
23. Simard J.M., Woo S.K., Schwartzbauer G.T., Gerzanich V.Sulfonylurea receptor 1 in central nervous system injury: a
focused review // Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 9, pp. 1699–1717, 2012.
24. Ortega F.J., Gimeno-Bayon J., Espinosa-Parrilla J.F., Carrasco J.L., Batlle M., Pugliese M., Mahy N., Rodriguez M.
J. ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats //
Exp. Neurol. 2012;235:282–296.
25. Ortega F.J., Jolkkonen J., Mahy N., Rodriguez M.J. Gliben clamide enhances neurogenesis and improves long-term func- tional recovery after transient focal cerebral ischemia //J. Cereb. BloodFlowMetab. 2013; 33:356–364.
26. Dahmane N, Ruiz i Altaba A.Sonic hedgehog regulates the growth and patterning of the cerebellum. Development.19
99;126(14):3089–100.
27. Wallace VA. Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the deve
loping mouse cerebellum. Curr Biol. 1999;9(8):445–8.
28. Wechsler-Reya RJ, Scott MP. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.
Neuron. 1999;22(1):103–14.
29. Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C.Sonic hedgehog signaling regulates a no
vel epithelial progenitor domain of the hindbrain choroidplexus. Development. 2009;136(15):2535–43.
30. Nielsen CM, Dymecki SM.Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev
Biol. 2010;340(2):430–7.
31. Бабиянц, А.Я. Мозговое кровообращение, физиологические аспекты и современные методы исследования / А.Я. Бабиянц, Я.А. Хананашвили // Журнал фундаментальной медицины и биологии.– 2018. – № 3. – С. 46–54.
32. Walter HJ, Berry M, Hill DJ, Cwyfan-Hughes S, Holly JM, Logan A. Distinct sites of insulin-like growth factor
(IGF)-II expression and localization in lesioned rat brain:possible roles of IGF binding proteins (IGFBPs) in the me
diation of IGF-II activity. Endocrinology. 1999;140(1):520–32.

Для цитирования

Шувалова М.С., Шидаков Ю.Х-М., Жанузаков Д.З. Влияние глибенкламида на изменения мозжечка после черепно-мозговой травмы. Научно-практический журнал «Здравоохранение Кыргызстана» 2024, № 2, с. 48-56. https://dx.doi.org/10.51350/zdravkg2024.2.6.6.48.56

English
About authors

Shuvalova Maria Sergeevna, Candidate of Medical Sciences, Assistant of the Department of Therapy, International School of Medicine “International University of Kyrgyzstan”, Bishkek, Kyrgyz Republic

Shidakov Yusuf Hadji-Makhmudovich, Candidate of Medical Sciences, Head of the Laboratory of Experimental Modeling of Pathological Processes at the Kyrgyz-Russian Slavic University named after. B.N. Yeltsin, Bishkek, Kyrgyz Republic

Zhanuzakov Dastan Zamirovich, graduate student of the Department of Surgical Dentistry of the Kyrgyz-Russian Slavic University named after B.N. Yeltsin, Bishkek, Kyrgyz Republic

References

1. Simard J.M., Geng Z., Woo S.K., Ivanova S., Tosun C., Melnichenko L., Gerzanich V. Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subara chnoid hemorrhage // J. Cereb. BloodFlowMetab.2009; 29:317–330.
2. Simard J.M., Chen M., Tarasov K.V. Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke // Nature Medicine. Vol. 12, no. 4, pp.433–440, 2006.
3. Simard J.M., Chen M., Tarasov K.V., Bhatta S., Ivanova S., Melnitchenko L. et al. Newly expressed SUR1-regulated
NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke // Nat Med. 2006;12:433–440.
4. Simard J.M., Kent T.A., Chen M., Tarasov K.V., Gerzanich V. (2007). Brain oedema in focal ischemia: molecular patho
physiology and theoretical implications // Lancet Neurol.6, 258–268.
5. Shuvalova M.S., Shidakov Yu.Kh.M., Zhanuzakov D.Z., Mamytova A.B. Traumatic brain injury and mountains / M.S. Shu
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13. Simard, J.M., Sheth, K.N., Kimberly, W.T., Stern, B., Del Zoppo, G.J., Jacobson, S., Gerzanich, V. Glibenclamide in
cerebral ischemia and stroke // Neurocritical care, 20(2), (2014). 319–333.
14. Khanna A., Walcott B.P., Kahle K.T., Simard J.M. Effect of glibenclamide on the prevention of secondary brain injury
following ischemic stroke in humans // Neurosurgical Focus 36 (1), E11.
15. New neurons follow the flow of cerebrospinal fluid in the adult brain. Sawamoto K, Wichterle H, Gonzalez-Perez O,
Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein JL, Tessier-Lavigne M, Oka
no H, Alvarez-Buylla A. Science. 2006 Feb 3; 311(5761):629-32. doi: 10.1126/science.1119133.
16. Patterson S.L, Grady M.S, Bothwell M. Nerve growth factor and a fibroblast growth factor-like neurotrophic activity in
cerebrospinal fluid of brain injured human patients. Brain Res.1993 Mar 5; 605(1):43-9.doi:10.1016/0006-8993(93)
91354-u. PMID: 8467388.
17. Yang K, Perez-Polo JR, Mu XS, Yan HQ, Xue JJ, IwamotoY, Liu SJ, Dixon CE, Hayes RL. Increased expression of brain-derived neurotrophic factor but not neurotrophin-3mRNA in rat brain after cortical impact injury. J Neurosci
Res. 1996 Apr 15;44(2):157-64. doi: 10.1002/(SICI)1097-4547(19960415)44:2<157::AID-JNR8>3.0.CO;2-C. PMID:
8723224.
18. Cheng, Q Di Liberto, V Caniglia, G Mudo, G. Time-course of GDNF and its receptor expression after brain injury in
the rat. Neurosci Lett. 2008 Jul 4;439(1):24-9. Epub 2008 May 1. RGD ID:2324932.
19. Shore PM, Jackson EK, Wisniewski SR, Clark RS, Adelson PD, Kochanek PM. Vascular endothelial growth factor is
increased in cerebrospinal fluid after traumatic brain injury in infants and children. Neurosurgery. 2004;54:605–611.
discussion 611-602.
20. Seino S., Shibasaki T., Minami K. Hancreatic beta-cell signaling: toward better understanding of diabetes and its consequences
atment // Proc.Jpn. Acad. Ser B Phys Biol. Sept.2010 86 No. 6 563–577.
21. Simard, J.M., Sheth, K.N., Kimberly, W.T., Stern, B., Del Zoppo, G.J., Jacobson, S., Gerzanich, V. Glibenclamide in
cerebral ischemia and stroke // Neurocritical care, 20(2), (2014). 319–333.
22. Simard J.M., Woo S.K., Gerzanich V. Transient receptor potential melastatin 4 and cell death // Pflugers Arch. 2012;
464:573–82.

23. Simard J.M., Woo S.K., Schwartzbauer G.T., Gerzanich V.Sulfonylurea receptor 1 in central nervous system injury: a
focused review // Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 9, pp. 1699–1717, 2012.

24. Ortega F.J., Gimeno-Bayon J., Espinosa-Parrilla J.F., Carrasco J.L., Batlle M., P Ugliese M., Mahy N., Rodriguez M.
J. ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats //
Exp. Neurol. 2012;235:282–296.
25. Ortega F.J., Jolkkonen J., Mahy N., Rodriguez M.J. Gliben clamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia //J. Cereb. BloodFlowMetab. 2013; 33:356–364.
26. Dahmane N, Ruiz i Altaba A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development.19
99;126(14):3089–100.
27. Wallace VA. Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the deve
loping mouse cerebellum. Curr Biol. 1999;9(8):445–8.
28. Wechsler-Reya RJ, Scott MP. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.
Neuron. 1999;22(1):103–14.
29. Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C. Sonic hedgehog signaling regulates a no
vel epithelial progenitor domain of the hindbrain choroidplexus. Development. 2009;136(15):2535–43.
30. Nielsen CM, Dymecki SM. Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev
Biol. 2010;340(2):430–7.
31. Babiyants, A.Ya. Cerebral circulation, physiological aspects and modern research methods / A.Ya. Babiyants, Ya.A. Khananashvili // Journal of fundamental medicine and biology. – 2018. – No. 3. – P. 46–54.
32. Walter HJ, Berry M, Hill DJ, Cwyfan-Hughes S, Holly JM, Logan A. Distinct sites of insulin-like growth factor
(IGF)-II expression and localization in lesioned rat brain: possible roles of IGF binding proteins (IGFBPs) in the me
diation of IGF-II activity. Endocrinology. 1999;140(1):520–32.

For citation

Shuvalova M.S., Shidakov Yu.X-M., Zhanuzakov D.Z. The effect of glibenclamide on changes in the cerebellum after
traumatic brain injury.Scientific and practical journal “Health care of Kyrgyzstan” 2024 No.2, p.48-56. https://dx.doi.org/10.51350/zdravkg2024.2.6.6.48.56

Kyrgyz
Авторлор жөнүндө

Шувалова Мария Сергеевна, медицина илимдеринин кандидаты, «Кыргызстандын Эл аралык университети» Эл аралык медицина мектебинин терапия кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы

Шидаков Юсуф Хаджи-Махмудович, медицина илимдеринин кандидаты, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин патологиялык процесстерди эксперименталдык моделдөө лабораториясынын башчысы, Бишкек, Кыргыз Республикасы

Жанузаков Дастан Замирович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин хирургиялык стоматология кафедрасынын аспиранты, Бишкек, Кыргыз Республикасы

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Цитата үчүн

Шувалова М.С., Шидаков Ю.Х-М., Жанузаков Д.З. Глибенкламиддин мээ жаракаттан кийин мээдеги өзгөрүүлөргө таасири. "Кыргызстандын саламаттык сактоо"  илимий-практикалык журналы 2024, № 2, б. 48-56 https://dx.doi.org/10.51350/zdravkg2024.2.6.6.48.56

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