When looked at the latest news for 2021, we can see that tens of millions of people have contracted the coronavirus.
More than a million people have died or are facing long-term health effects from the virus. The review article is devoted to the study of the biochemical specificities of changing the algorithm of hyaluronic acid in the alveoli of the
lungs with Covid-19. An analysis of the literature covering the problem to date is carried out. On computed tomograms, which do each patient with suspected coronavirus, lucent areas are noted - “ground glass” syndrome, that
contain liquid. So, the analysis of the literature showed that the coronavirus damages the membrane (membranes) of
the alveoli, which causes the outpouring of hyaluronic acid from them. A group of scientists assume that hyaluronic
acid is the leading cause of death in severe Covid-19 lung infections. The study showed that COVID-19 demonstrates
a high level of proinflammatory of cytokines in the affected alveoles and in endothelial cells of blood vessels, in addition to increasing neutrophil extracellular traps that activate hemostatic factors. Consequently, thrombosis in the
pulmonary microcirculation leads to an increase in respiratory failure. The article further describes the role of
hyaluronic acid and the concept of “bradykinin storm” in the development of respiratory failure and the therapeutic
effects of COVID-19 heparin. Scientists have found that in addition to the anticoagulant effect, heparin can bind to
the “spike” protein of the SARS-CoV-2 virus and function as a competitive inhibitor for the entry of viruses, thereby
reducing the infectivity of the process .
This article reviews the literature on the role of private health care organizations in detecting, diagnosing, treating,
and preventing tuberculosis. Literature from 2001 to 2021 was reviewed, including World Health Organization guidelines
and global reports, STOP TB partnership guidelines, and articles by selected foreign and local authors. Publications
of foreign authors were available on-line, there are several publications from the neighboring countries of Kyrgyzstan.
The example of public-private partnership organization in Bangladesh, Vietnam and Georgia was given. In the publications,
most authors agree that it is necessary to involve private health care organizations in TB management to increase
access in the fight against the disease, but there are differences in the organization of public-private partnership model,
in which it is necessary to ensure quality monitoring of diagnosis, treatment and tracking of patients on TB treatment.