Health care of Kyrgyzstan
Zdravoohraneniye Kyrgyzstana

ISSN 1694-8068 (Print)

ISSN 1694-805X (Online)

Determinants of serum 25(OH)D indicators of Kyrgyzstan

Determinants of serum 25(OH)D indicators of Kyrgyzstan
Полный текст Full text Толук текст  

Abstract

This article describes for the first time the determinants of fluctuations in the mean serum 25 (OH) D levels in the indigenous population of Kyrgyzstan. Relevance. Vitamin D is now receiving increasing attention. Deficiency of 25 (OH) D contributes to the development of both skeletal (rickets, osteopenia, osteoporosis) and non-skeletal pathological effects (dermatoses, hypertension, obesity, oncological, endocrine, autoimmune and infectious diseases). Serum 25-hydroxyvitamin D levels> 75 nmol / L, or 30 ng / mL, are essential for maintaining human health. Objective of the study- to find out whether gender and seasonal fluctuations in UVR levels are determinants of vitamin 25 (OH) D deficiency among healthy indigenous people of Kyrgyzstan. Material and methods. A pilot multicenter cross-sectional study of the serum 25 (OH) D level of the indigenous inhabitants of Kyrgyzstan (41 ° N, 75 ° E; duration of sunshine 1700-2900 h / year) was carried out. The sample consisted of 218 people, of which 99 (45.4%) were men and 119 (54.6%) were women. The average age of the representative sample was 38 ± 1.0 (95% CI 36.0 - 40.1) years. Results. The mean serum 25 (OH) D3 level in the total sample was 46.9 ± 1.1 nmol / L (95% CI 44.8 - 49.1 nmol / L), which corresponds to a deficit (<50 nmol / L). At the same time, in men, the average indicator 25 (OH) D3 was 50.0 ± 1.5 nmol / L (95% CI 46.9 - 53.0 nmol / L), in women 44.5 ± 1.5 nmol / L ( 95% CI 41.5 - 47.5 nmol / L), p <0.013. There were statistically significant (p <0.026) seasonal fluctuations in serum 25 (OH) D3 from 41.7 ± 2.3 (95% CI 37.1 - 46.4) in the spring to 50.0 ± 2.1 (95% CI 45.9 - 54.2) in the fall. Conclusion. Regardless of statistically significant gender and seasonal fluctuations, as well as the geographic location of the country (41 ° N, 75 ° E) and the duration of sunshine (1700-2900 hours / year.), The average serum 25 (OH) D3 does not reach an adequate level (> 75 nmol / L).

About the authors

Исупова Алена Анатольевна, кандидат медицинских наук, старший преподаватель кафедры дерматовенерологии и фтизиатрии Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика;

Исупов Роман Вячеславович, аспирант, Кыргызско-Российского Славянского университета им. Б.Н.Ельцина, Бишкек,Кыргызская Республика

Isupova Alena Anatolyevna , Candidate of Medical Sciences, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Senior Lecturer of the Department of Dermatovenerology and Phthisiology, Bishkek, Kyrgyz Republic;
Isupov Roman Alekeslavovich, PhD student, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Bishkek, Kyrgyz Republic

Исупова Алена Анатольевна, медицина илимдеринин кандидаты, Б.Н. Ельцин атындагы Кыргыз-Россия славиян университетинун тери-венерология жана фтизиатрия кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы;

Исупов Роман Вячеславович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин аспиранты, Бишкек, Кыргыз Республикасы

References

  1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.
  2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acute
    hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.
  3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.
  4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin
    D3. The Lancet. 1982;319(8263):74–76.
  5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy:
    toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.
  6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of
    prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol
    (2013) 5:222–34.
  7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.
  8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau
    AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.
  9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency.
    Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.
  10. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.
  11. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.
  12. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes among
    acute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.

1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.

2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acutehip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.

3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.

4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet. 1982;319(8263):74–76.

5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.

6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol (2013) 5:222–34.

7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.

8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.

9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency.

10. Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.

11. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.

12. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.

13. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes amongacute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.

  1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.
  2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acutehip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.
  3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.
  4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet. 1982;319(8263):74–76.
  5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.
  6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol (2013) 5:222–34.
  7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.
  8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.
  9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency. Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.
  10. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.
  11. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.
  12. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes amongacute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.
Для цитирования

Исупова А.А. , Исупов Р.В. Детерминанты показателей сывороточного 25 (OH) D коренных жителей Кыргызстана. Здравоохранение Кыргызстана 2021, № 4, с. 34-39.

https://doi.org/10.51350/zdravkg2021124334 

For citation

Isupova A.A., Isupov R.V. Determinants of serum 25 (OH)D indicators of Kyrgyzstan.
Health care of Kyrgyzstan 2021, No. 4, pp. 34-39. 

https://doi.org/10.51350/zdravkg2021124334

Цитата үчүн

Исупова А.А. , Исупов Р.В. Кыргызстандын 25 (OH) D көрсөткүчтөрүнүн сырторунун аныктоочулары.
Кыргызстандын Cаламаттык Cактоо 2021, № 4, б. 34-39. 

https://doi.org/10.51350/zdravkg2021124334 

Authors Isupova A.A., Isupov R.V.
Link doi.org https://doi.org/10.51350/zdravkg2021124334
Pages 34-39
Keywords health, dermatoses, osteoporosis, bone quality, serum 25 (OH) D3, vitamin D deficiency, seasonal fluctuations of the Ural Federal District, Kyrgyzstan
Russian
Об авторах

Исупова Алена Анатольевна, кандидат медицинских наук, старший преподаватель кафедры дерматовенерологии и фтизиатрии Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика;

Исупов Роман Вячеславович, аспирант, Кыргызско-Российского Славянского университета им. Б.Н.Ельцина, Бишкек,Кыргызская Республика

Полный текст

 PDF (RUS)

Список литературы
  1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.
  2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acute
    hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.
  3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.
  4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin
    D3. The Lancet. 1982;319(8263):74–76.
  5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy:
    toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.
  6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of
    prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol
    (2013) 5:222–34.
  7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.
  8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau
    AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.
  9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency.
    Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.
  10. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.
  11. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.
  12. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes among
    acute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.
Для цитирования

Исупова А.А. , Исупов Р.В. Детерминанты показателей сывороточного 25 (OH) D коренных жителей Кыргызстана. Здравоохранение Кыргызстана 2021, № 4, с. 34-39.

https://doi.org/10.51350/zdravkg2021124334 

English
About authors

Isupova Alena Anatolyevna , Candidate of Medical Sciences, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Senior Lecturer of the Department of Dermatovenerology and Phthisiology, Bishkek, Kyrgyz Republic;
Isupov Roman Alekeslavovich, PhD student, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Bishkek, Kyrgyz Republic

Full text

 PDF (RUS)

References

1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.

2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acutehip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.

3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.

4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet. 1982;319(8263):74–76.

5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.

6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol (2013) 5:222–34.

7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.

8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.

9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency.

10. Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.

11. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.

12. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.

13. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes amongacute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.

For citation

Isupova A.A., Isupov R.V. Determinants of serum 25 (OH)D indicators of Kyrgyzstan.
Health care of Kyrgyzstan 2021, No. 4, pp. 34-39. 

https://doi.org/10.51350/zdravkg2021124334

Kyrgyz
Авторлор жөнүндө

Исупова Алена Анатольевна, медицина илимдеринин кандидаты, Б.Н. Ельцин атындагы Кыргыз-Россия славиян университетинун тери-венерология жана фтизиатрия кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы;

Исупов Роман Вячеславович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин аспиранты, Бишкек, Кыргыз Республикасы

Толук текст

 PDF (RUS)

Шилтемелер
  1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.
  2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acutehip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.
  3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.
  4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet. 1982;319(8263):74–76.
  5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.
  6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol (2013) 5:222–34.
  7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.
  8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.
  9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency. Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.
  10. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.
  11. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.
  12. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes amongacute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.
Цитата үчүн

Исупова А.А. , Исупов Р.В. Кыргызстандын 25 (OH) D көрсөткүчтөрүнүн сырторунун аныктоочулары.
Кыргызстандын Cаламаттык Cактоо 2021, № 4, б. 34-39. 

https://doi.org/10.51350/zdravkg2021124334 

Views: 5298
Copyright MAXXmarketing GmbH
JoomShopping Download & Support