Кыргызстандын Саламаттык Сактоо
Zdravoohraneniye Kyrgyzstana
ISSN 1694-8068 (Print)
ISSN 1694-805X (Online)

Кыргызстандын 25(OH)D көрсөткүчтөрүнүн сырторунун аныктоочулары

Кыргызстандын 25(OH)D көрсөткүчтөрүнүн сырторунун аныктоочулары
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Корутунду

Бул макалада биринчи жолу Кыргызстандын түпкү калкынын кан сары суусунун орточо 25 (OH) D деңгээлинин флуктуациясынын детерминанттары сүрөттөлөт. Маанилүүлүк. Витамин D азыр көбүрөөк көңүл буруп жатат. 25 (OH) D жетишсиздиги скелеттик (рахит, остеопения, остеопороз) жана скелеттик эмес патологиялык эффекттердин (дерматоздор, гипертония, семирүү, онкологиялык, эндокриндик, аутоиммундук жана инфекциялык оорулар) өнүгүшүнө өбөлгө түзөт. Сарысудагы 25-гидроксивитамин D деңгээли> 75 нмоль/л же 30 нг/мл адамдын ден соолугун сактоо үчүн зарыл. Изилдөөнүн максаты -Кыргызстандын дени сак жергиликтүү калкынын арасында 25 (OH) D витамининин жетишсиздигинин детерминанттары UVR деңгээлиндеги гендердик жана сезондук термелүүлөр экендигин аныктоо. Материалдар жана ыкмалар. Кыргызстандын түпкү жашоочуларынын кан сары суусунун 25 (OH) D деңгээлине (41° ш., 75° E; күндүн нурунун узактыгы 1700-2900 с/жыл) пилоттук көп борборлуу кесилиш изилдөөсү жүргүзүлгөн. Тандалган 218 адам, анын 99у (45,4%) эркектер жана 119у (54,6%) аялдар. Өкүлчүлүктүн орточо жашы 38 ± 1,0 (95% CI 36,0 - 40,1) жылды түздү. Натыйжалар. Жалпы үлгүдөгү орточо кан 25 (OH) D3 деңгээли 46,9 ± 1,1 нмоль / л (95% CI 44,8 - 49,1 нмоль / л) болгон, бул тартыштыкка (<50 нмоль / л) туура келет. Ошол эле учурда эркектерде 25 (OH) D3 орточо көрсөткүчү 50,0 ± 1,5 нмоль/л (95% CI 46,9 - 53,0 нмоль/л), аялдарда 44,5 ± 1,5 нмоль/л (95% CI 41,5 - 47,5) болгон. nmol / L), p <0,013. 41,7 ± 2,3 (95% CI 37,1 - 46,4) жазында 50,0 ± 2,1 (95% CI 45,9 - 54,2) күзүндө 41,7 ± 2,3 (OH) D3 25 (OH) D3 статистикалык маанилүү (р <0,026) сезондук термелүүлөр болгон. Жыйынтыгы. Статистикалык жактан маанилүү гендердик жана сезондук термелүүлөргө, ошондой эле өлкөнүн географиялык абалына (41° N, 75° E) жана күндүн нурунун узактыгына (1700-2900 с/жыл.), орточо кан сары суусу 25 (OH) D3 карабастан. адекваттуу деңгээлге жетпейт (> 75 нмоль/л).

Авторлор жөнүндө

Исупова Алена Анатольевна, кандидат медицинских наук, старший преподаватель кафедры дерматовенерологии и фтизиатрии Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика;

Исупов Роман Вячеславович, аспирант, Кыргызско-Российского Славянского университета им. Б.Н.Ельцина, Бишкек,Кыргызская Республика

Isupova Alena Anatolyevna , Candidate of Medical Sciences, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Senior Lecturer of the Department of Dermatovenerology and Phthisiology, Bishkek, Kyrgyz Republic;
Isupov Roman Alekeslavovich, PhD student, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Bishkek, Kyrgyz Republic

Исупова Алена Анатольевна, медицина илимдеринин кандидаты, Б.Н. Ельцин атындагы Кыргыз-Россия славиян университетинун тери-венерология жана фтизиатрия кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы;

Исупов Роман Вячеславович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин аспиранты, Бишкек, Кыргыз Республикасы

Шилтемелер

  1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.
  2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acute
    hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.
  3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.
  4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin
    D3. The Lancet. 1982;319(8263):74–76.
  5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy:
    toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.
  6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of
    prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol
    (2013) 5:222–34.
  7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.
  8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau
    AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.
  9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency.
    Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.
  10. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.
  11. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.
  12. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes among
    acute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.

1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.

2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acutehip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.

3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.

4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet. 1982;319(8263):74–76.

5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.

6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol (2013) 5:222–34.

7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.

8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.

9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency.

10. Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.

11. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.

12. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.

13. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes amongacute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.

  1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.
  2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acutehip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.
  3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.
  4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet. 1982;319(8263):74–76.
  5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.
  6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol (2013) 5:222–34.
  7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.
  8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.
  9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency. Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.
  10. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.
  11. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.
  12. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes amongacute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.
Для цитирования

Исупова А.А. , Исупов Р.В. Детерминанты показателей сывороточного 25 (OH) D коренных жителей Кыргызстана. Здравоохранение Кыргызстана 2021, № 4, с. 34-39.

https://doi.org/10.51350/zdravkg2021124334 

For citation

Isupova A.A., Isupov R.V. Determinants of serum 25 (OH)D indicators of Kyrgyzstan.
Health care of Kyrgyzstan 2021, No. 4, pp. 34-39. 

https://doi.org/10.51350/zdravkg2021124334

Цитата үчүн

Исупова А.А. , Исупов Р.В. Кыргызстандын 25 (OH) D көрсөткүчтөрүнүн сырторунун аныктоочулары.
Кыргызстандын Cаламаттык Cактоо 2021, № 4, б. 34-39. 

https://doi.org/10.51350/zdravkg2021124334 

Авторлор Исупова А.А., Исупов Р.В.
Ссылка doi.org https://doi.org/10.51350/zdravkg2021124334
Беттер 34-39
Негизги сөздөр ден соолук, дерматоздор, остеопороз, сөөктүн сапаты, сарысу 25 (OH) D3, D витамининин жетишсиздиги, мезгилдик термелүүлөр, Кыргызстан
Орусча
Об авторах

Исупова Алена Анатольевна, кандидат медицинских наук, старший преподаватель кафедры дерматовенерологии и фтизиатрии Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика;

Исупов Роман Вячеславович, аспирант, Кыргызско-Российского Славянского университета им. Б.Н.Ельцина, Бишкек,Кыргызская Республика

Полный текст

 PDF (RUS)

Список литературы
  1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.
  2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acute
    hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.
  3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.
  4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin
    D3. The Lancet. 1982;319(8263):74–76.
  5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy:
    toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.
  6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of
    prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol
    (2013) 5:222–34.
  7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.
  8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau
    AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.
  9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency.
    Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.
  10. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.
  11. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.
  12. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes among
    acute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.
Для цитирования

Исупова А.А. , Исупов Р.В. Детерминанты показателей сывороточного 25 (OH) D коренных жителей Кыргызстана. Здравоохранение Кыргызстана 2021, № 4, с. 34-39.

https://doi.org/10.51350/zdravkg2021124334 

Англисче
About authors

Isupova Alena Anatolyevna , Candidate of Medical Sciences, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Senior Lecturer of the Department of Dermatovenerology and Phthisiology, Bishkek, Kyrgyz Republic;
Isupov Roman Alekeslavovich, PhD student, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Bishkek, Kyrgyz Republic

Full text

 PDF (RUS)

References

1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.

2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acutehip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.

3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.

4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet. 1982;319(8263):74–76.

5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.

6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol (2013) 5:222–34.

7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.

8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.

9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency.

10. Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.

11. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.

12. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.

13. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes amongacute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.

For citation

Isupova A.A., Isupov R.V. Determinants of serum 25 (OH)D indicators of Kyrgyzstan.
Health care of Kyrgyzstan 2021, No. 4, pp. 34-39. 

https://doi.org/10.51350/zdravkg2021124334

Кыргызча
Авторлор жөнүндө

Исупова Алена Анатольевна, медицина илимдеринин кандидаты, Б.Н. Ельцин атындагы Кыргыз-Россия славиян университетинун тери-венерология жана фтизиатрия кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы;

Исупов Роман Вячеславович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин аспиранты, Бишкек, Кыргыз Республикасы

Толук текст

 PDF (RUS)

Шилтемелер
  1. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013 Jan 1; 5(1): 51–108.
  2. Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M. Half of the patients with an acutehip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int. 2005; 16(12):2018-24.
  3. Cashman Kevin D. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue International. 2019;106(1):14–29.
  4. Clemens T. L., Henderson S. L., Adams J. S., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet. 1982;319(8263):74–76.
  5. Mut-Salud N, Alvarez PJ, Garrido JM, Carrasco E, Aranega A, Rodriguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxid. Med. Cell. Longev., 2016: 6719534.
  6. Finamor DC, Sinigaglia-Coimbra R, Neves LCM, Gutierrez M, Silva JJ, Torres LD, et al. . A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol (2013) 5:222–34.
  7. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016; 103:1033.
  8. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-345.
  9. Jacob M, Censani M. 13-Year-Old Boy Presenting with Bilateral Femur Fractures in the Setting of Severe Vitamin D Deficiency. Case Rep Pediatr. 2021;4;2021:2440999 doi: 10.1016/s0140-6736(82)90214-8.
  10. Chang S.W., Lee H.C. Vitamin D and Health—The missing vitamin in humans. Pediatr. Neonatol. 2019;60:237–244.
  11. Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective.Front Neurosci. 2021 Sep 22;15:726457.
  12. Wei L, Chen C, Dai YQ, Ding L, Li HY, Lin YJ, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcomes amongacute ischemic stroke patients receiving intravenous thrombolysis. Chin Med J 2019; 132:491–494.
Цитата үчүн

Исупова А.А. , Исупов Р.В. Кыргызстандын 25 (OH) D көрсөткүчтөрүнүн сырторунун аныктоочулары.
Кыргызстандын Cаламаттык Cактоо 2021, № 4, б. 34-39. 

https://doi.org/10.51350/zdravkg2021124334 

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