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Intracranial meningiomas: correlations between clinical picture, histopathology and genetic markers

https://dx.doi.org/10.51350/zdravkg2022.4.10.5.41
Intracranial meningiomas: correlations between clinical picture, histopathology and genetic markers
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PDF (RUS)
Abstract About the authors References

Abstract

Goal. Solving the question of whether there are certain genetic markers that correlate with specific clinical characteristics of meningiomas, including multiplicity, relapses and erosion of the cranial vault. Methods. Thirty-eight meningioma patients were selected for this study. During the operation, blood and tumor samples were taken for histopathological, cytogenetic and molecular analysis. The loss of heterozygosity (LOH) on chromosomes 1p and 22q was investigated, and the NF2 gene on 22q12.2 was tested for the presence of pathogenic mutations. The results obtained. The most frequent localization of tumors were convexital (25%) and parasagittal (21%). Histology results showed that 86.8% of patients had grade I tumors, and the rest had grade II tumors. Pathogenic nonsense mutation R341X in the NF2 gene was detected in only one patient. LOH on each of chromosomes 1p and 22q was observed in 44.7% of patients. Significant associations were found between the presence of certain tumor characteristics and the male sex (p = 0.0059) and 22q LOH (p = 0.0425). We calculated that the presence of 22q LOH increases the probability of developing a tumor that exhibits multiplicity, recurrence or erosion of the cranial vault in humans by about four times (OR = 4.8; 95% CI: 1.2–23.4). The correction for gender increased this effect (OR = 6.1; 95% CI: 1.1–48.7). Conclusions. The data obtained show that male patients and meningioma patients with 22q LOH are more likely to develop tumors showing multiplicity, recurrence or erosion of the cranial vault. We recommend that this group of patients be monitored more closely. Further studies are needed to determine the benefit of adjuvant radiation therapy in this scenario.

About the authors

Ырысов Кенешбек Бакирбаевич, доктор медицинских наук, профессор, член-корр. НАН КР, врач-нейрохирург, кафедры нейрохирургии Кыргызской государственной медицинской академии им. И. К.Ахунбаева,Бишкек, Кыргызская Республика

Арстанбеков Нематилла Абдуллаевич, докторант, врач-нейрохирург, кафедры нейрохирургии Кыргызской государственной медицинской академии им. И. К. Ахунбаева,Бишкек, Кыргызская Республика

Yrysov Keneshbek Bakirbayevich, MD, Professor, Corresponding member National Academy of Sciences of the Kyrgyz Republic, neurosurgeon,Department of Neurosurgery, Kyrgyz State Medical Academy I. K. Akhunbaeva, Bishkek, Kyrgyz Republic
Arstanbekov Nematilla Abdullaevich, doctoral student, neurosurgeon, Department of Neurosurgery, Kyrgyz State Medical Academy named after I. K. Akhunbaeva, Bishkek, Kyrgyz Republic

Ырысов Кенешбек Бакирбаевич, медицина илимдеринин доктору, профессор, КР УИА корр.-мүчөсү,  И. К. Ахунбаев атындагы Кыргыз мамлекетик медициналык академиясынын нейрохирургия кафедрасынын нейрохирург -дарыгери, Бишкек, Кыргыз Республикасы

Арстанбеков Нематилла Абдуллаевич, докторант, И. К. Ахунбаев атындагы Кыргыз мамлекетик медициналык академиясынын нейрохирургия кафедрасынын нейрохирург -дарыгери, Бишкек, Кыргыз Республикасы

References

1. Zang K.D., Singer H. Chromosomal constitution of meningiomas. Nature 2019;216:84-5.
2. Mark J., Levan G., Mielman F. Identification by fluorescence of the G chromosome loss in human meningiomas. Heredias 2019;71:163-8.
3. Dumanski J.P., Carlbom E., Collins V.P. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 2018;84:9275-9.
4. Dumanski J.P., Rouleau G.A., Nodenskjold M. Molecular genetic analysis of chromosome 22 in 81 cases of meningioma.Cancer Res 2019;50:5863-76.
5. Sanson M., Richard S., Delattre O. Allelic loss on chromosome 22 correlates with histopathological predictors of recurrence of meningiomas. Int J Cancer 2019;50:391-4.
6. Berra B., Papi L., Bigozzi U. Correlation between cytogenetic data and ganglioside pattern in human meningiomas. Int J Cancer 2019;47:329-33.
7. Seizinger B.R., De la Monte S., Atkins L. Molecular genetic approach to human meningioma: Loss of genes on chromosome 22.Proc Natl Acad Sci USA 2018;84:5419-23.
8. Kim J., Lee S., Rhee C. Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas. J Neurooncol 2019;40:101-6.
9. Battersby R.D.E., Ironside J.W., Maltby E.L. Inherited multiple meningiomas: A clinical, pathological and cytogenetic study of an affected family. J Neurol Neurosurg Psychiatry 2018;49:362-8.
10. Leuraud P., Dezamis E., Aguirre-Cruz L. Prognostic value of allelic losses and telomerase activity in meningiomas. J Neurosurg 2021;100:303309.
11. Arinami T., Kondo I., Hamaguchi H. Multifocal meningiomas in a patient with a constitutional ring chromosome 22. J MedGenet 2016;23:178-80.
12. Ruttledge M., Sarrazin J., Rangaratnam S. Evidence for the complete inactivation of the NF2 gene in the majority of sporadicmeningiomas. Nat Genet 2019;6:180-4.
13. Simon M., Bostrom J.P., Hartmann C. Molecular genetics of meningiomas: from basic research to potential clinical applications.Neurosurgery 2017;60:787-98.
14. Zankl H., Zang K.D. Correlation between clinical and cytogenetical data in 180 human meningiomas. Cancer Genet Cytogenet 2018;1:351-6.
15. Greider C. Telomerase activation. One step on the road to cancer? Trends Genet 2019;15:109-12.
16. Lee J.Y.K., Finkelstein S., Hamilton R.L. Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 2014;55(5): 1163-73.
17. Rozen S., Skaletsky H.J. Primer on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S. Bioin formatics Methods and Protocols: Methods in Molecular Biology. Totowa NJ: Humana Press, 2020:365-86.
18. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl AcidsSymp Ser 2019;41:95-8.
19. R Development Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, http://www.R- project.org, 2017.

1. Zang K.D., Singer H. Chromosomal constitution of meningiomas. Nature 2019;216:84-5.
2. Mark J., Levan G., Mielman F. Identification by fluorescence of the G chromosome loss in human meningiomas. Heredias 2019;71:163-8.
3. Dumanski J.P., Carlbom E., Collins V.P. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 2018;84:9275-9.
4. Dumanski J.P., Rouleau G.A., Nodenskjold M. Molecular genetic analysis of chromosome 22 in 81 cases of meningioma.Cancer Res 2019;50:5863-76.
5. Sanson M., Richard S., Delattre O. Allelic loss on chromosome 22 correlates with histopathological predictors of recurrence of meningiomas. Int J Cancer 2019;50:391-4.
6. Berra B., Papi L., Bigozzi U. Correlation between cytogenetic data and ganglioside pattern in human meningiomas. Int J Cancer 2019;47:329-33.
7. Seizinger B.R., De la Monte S., Atkins L. Molecular genetic approach to human meningioma: Loss of genes on chromosome 22.Proc Natl Acad Sci USA 2018;84:5419-23.
8. Kim J., Lee S., Rhee C. Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas. J Neurooncol 2019;40:101-6.
9. Battersby R.D.E., Ironside J.W., Maltby E.L. Inherited multiple meningiomas: A clinical, pathological and cytogenetic study of an affected family. J Neurol Neurosurg Psychiatry 2018;49:362-8.
10. Leuraud P., Dezamis E., Aguirre-Cruz L. Prognostic value of allelic losses and telomerase activity in meningiomas. J Neurosurg 2021;100:303309.
11. Arinami T., Kondo I., Hamaguchi H. Multifocal meningiomas in a patient with a constitutional ring chromosome 22. J MedGenet 2016;23:178-80.
12. Ruttledge M., Sarrazin J., Rangaratnam S. Evidence for the complete inactivation of the NF2 gene in the majority of sporadicmeningiomas. Nat Genet 2019;6:180-4.
13. Simon M., Bostrom J.P., Hartmann C. Molecular genetics of meningiomas: from basic research to potential clinical applications.Neurosurgery 2017;60:787-98.
14. Zankl H., Zang K.D. Correlation between clinical and cytogenetical data in 180 human meningiomas. Cancer Genet Cytogenet 2018;1:351-6.
15. Greider C. Telomerase activation. One step on the road to cancer? Trends Genet 2019;15:109-12.
16. Lee J.Y.K., Finkelstein S., Hamilton R.L. Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 2014;55(5): 1163-73.
17. Rozen S., Skaletsky H.J. Primer on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S. Bioin formatics Methods and Protocols: Methods in Molecular Biology. Totowa NJ: Humana Press, 2020:365-86.
18. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl AcidsSymp Ser 2019;41:95-8.
19. R Development Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, http://www.R- project.org, 2017.

1. Zang K.D., Singer H. Chromosomal constitution of meningiomas. Nature 2019;216:84-5.
2. Mark J., Levan G., Mielman F. Identification by fluorescence of the G chromosome loss in human meningiomas. Heredias 2019;71:163-8.
3. Dumanski J.P., Carlbom E., Collins V.P. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 2018;84:9275-9.
4. Dumanski J.P., Rouleau G.A., Nodenskjold M. Molecular genetic analysis of chromosome 22 in 81 cases of meningioma.Cancer Res 2019;50:5863-76.
5. Sanson M., Richard S., Delattre O. Allelic loss on chromosome 22 correlates with histopathological predictors of recurrence of meningiomas. Int J Cancer 2019;50:391-4.
6. Berra B., Papi L., Bigozzi U. Correlation between cytogenetic data and ganglioside pattern in human meningiomas. Int J Cancer 2019;47:329-33.
7. Seizinger B.R., De la Monte S., Atkins L. Molecular genetic approach to human meningioma: Loss of genes on chromosome 22.Proc Natl Acad Sci USA 2018;84:5419-23.
8. Kim J., Lee S., Rhee C. Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas. J Neurooncol 2019;40:101-6.
9. Battersby R.D.E., Ironside J.W., Maltby E.L. Inherited multiple meningiomas: A clinical, pathological and cytogenetic study of an affected family. J Neurol Neurosurg Psychiatry 2018;49:362-8.
10. Leuraud P., Dezamis E., Aguirre-Cruz L. Prognostic value of allelic losses and telomerase activity in meningiomas. J Neurosurg 2021;100:303309.
11. Arinami T., Kondo I., Hamaguchi H. Multifocal meningiomas in a patient with a constitutional ring chromosome 22. J MedGenet 2016;23:178-80.
12. Ruttledge M., Sarrazin J., Rangaratnam S. Evidence for the complete inactivation of the NF2 gene in the majority of sporadicmeningiomas. Nat Genet 2019;6:180-4.
13. Simon M., Bostrom J.P., Hartmann C. Molecular genetics of meningiomas: from basic research to potential clinical applications.Neurosurgery 2017;60:787-98.
14. Zankl H., Zang K.D. Correlation between clinical and cytogenetical data in 180 human meningiomas. Cancer Genet Cytogenet 2018;1:351-6.
15. Greider C. Telomerase activation. One step on the road to cancer? Trends Genet 2019;15:109-12.
16. Lee J.Y.K., Finkelstein S., Hamilton R.L. Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 2014;55(5): 1163-73.
17. Rozen S., Skaletsky H.J. Primer on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S. Bioin formatics Methods and Protocols: Methods in Molecular Biology. Totowa NJ: Humana Press, 2020:365-86.
18. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl AcidsSymp Ser 2019;41:95-8.
19. R Development Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, http://www.R- project.org, 2017.

Keywords
tumor , Outcome , risk factor , gender differences , meningioma
Для цитирования

Ырысов К.Б., Арстанбеков Н.А.Интракраниальные менингиомы: корреляции между клинической картиной, гистопатологией и генетическими маркерами.Здравоохранение Кыргызстана 2022, № 4, с. 41 -46. https://dx.doi.org/10.51350/zdravkg2022.4.10.5.41
For citation

Yrysov K. B., Arstanbekov N. A. Intracranial meningiomas: correlations between clinical picture, histopathology and ge
netic markers.Health care of Kyrgyzstan 2022, No.4, pp. 41-46. https://dx.doi.org/10.51350/zdravkg2022.4.10.5.41
Цитата үчүн

Ырысов К.Б., Арстанбеков Н.А. Интракраниалдык менингиомалар: клиникалык сүрөттөмө,гистопатология жана генетикалык маркерлер ортосундагы корреляция. Кыргызстандын саламаттык сактоо 2022, no 4, б. 41-46. https://dx.doi.org/10.51350/zdravkg2022.4.10.5.41
Authors Yrysov K.B. , Arstanbekov N. A.
Link doi.org https://dx.doi.org/10.51350/zdravkg2022.4.10.5.41
Pages 41-46
Keywords tumor, Outcome, risk factor, gender differences, meningioma
Russian
Об авторах

Ырысов Кенешбек Бакирбаевич, доктор медицинских наук, профессор, член-корр. НАН КР, врач-нейрохирург, кафедры нейрохирургии Кыргызской государственной медицинской академии им. И. К.Ахунбаева,Бишкек, Кыргызская Республика

Арстанбеков Нематилла Абдуллаевич, докторант, врач-нейрохирург, кафедры нейрохирургии Кыргызской государственной медицинской академии им. И. К. Ахунбаева,Бишкек, Кыргызская Республика
Полный текст

PDF (RUS)
Список литературы

1. Zang K.D., Singer H. Chromosomal constitution of meningiomas. Nature 2019;216:84-5.
2. Mark J., Levan G., Mielman F. Identification by fluorescence of the G chromosome loss in human meningiomas. Heredias 2019;71:163-8.
3. Dumanski J.P., Carlbom E., Collins V.P. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 2018;84:9275-9.
4. Dumanski J.P., Rouleau G.A., Nodenskjold M. Molecular genetic analysis of chromosome 22 in 81 cases of meningioma.Cancer Res 2019;50:5863-76.
5. Sanson M., Richard S., Delattre O. Allelic loss on chromosome 22 correlates with histopathological predictors of recurrence of meningiomas. Int J Cancer 2019;50:391-4.
6. Berra B., Papi L., Bigozzi U. Correlation between cytogenetic data and ganglioside pattern in human meningiomas. Int J Cancer 2019;47:329-33.
7. Seizinger B.R., De la Monte S., Atkins L. Molecular genetic approach to human meningioma: Loss of genes on chromosome 22.Proc Natl Acad Sci USA 2018;84:5419-23.
8. Kim J., Lee S., Rhee C. Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas. J Neurooncol 2019;40:101-6.
9. Battersby R.D.E., Ironside J.W., Maltby E.L. Inherited multiple meningiomas: A clinical, pathological and cytogenetic study of an affected family. J Neurol Neurosurg Psychiatry 2018;49:362-8.
10. Leuraud P., Dezamis E., Aguirre-Cruz L. Prognostic value of allelic losses and telomerase activity in meningiomas. J Neurosurg 2021;100:303309.
11. Arinami T., Kondo I., Hamaguchi H. Multifocal meningiomas in a patient with a constitutional ring chromosome 22. J MedGenet 2016;23:178-80.
12. Ruttledge M., Sarrazin J., Rangaratnam S. Evidence for the complete inactivation of the NF2 gene in the majority of sporadicmeningiomas. Nat Genet 2019;6:180-4.
13. Simon M., Bostrom J.P., Hartmann C. Molecular genetics of meningiomas: from basic research to potential clinical applications.Neurosurgery 2017;60:787-98.
14. Zankl H., Zang K.D. Correlation between clinical and cytogenetical data in 180 human meningiomas. Cancer Genet Cytogenet 2018;1:351-6.
15. Greider C. Telomerase activation. One step on the road to cancer? Trends Genet 2019;15:109-12.
16. Lee J.Y.K., Finkelstein S., Hamilton R.L. Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 2014;55(5): 1163-73.
17. Rozen S., Skaletsky H.J. Primer on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S. Bioin formatics Methods and Protocols: Methods in Molecular Biology. Totowa NJ: Humana Press, 2020:365-86.
18. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl AcidsSymp Ser 2019;41:95-8.
19. R Development Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, http://www.R- project.org, 2017.
Для цитирования

Ырысов К.Б., Арстанбеков Н.А.Интракраниальные менингиомы: корреляции между клинической картиной, гистопатологией и генетическими маркерами.Здравоохранение Кыргызстана 2022, № 4, с. 41 -46. https://dx.doi.org/10.51350/zdravkg2022.4.10.5.41
English
About authors

Yrysov Keneshbek Bakirbayevich, MD, Professor, Corresponding member National Academy of Sciences of the Kyrgyz Republic, neurosurgeon,Department of Neurosurgery, Kyrgyz State Medical Academy I. K. Akhunbaeva, Bishkek, Kyrgyz Republic
Arstanbekov Nematilla Abdullaevich, doctoral student, neurosurgeon, Department of Neurosurgery, Kyrgyz State Medical Academy named after I. K. Akhunbaeva, Bishkek, Kyrgyz Republic
References

1. Zang K.D., Singer H. Chromosomal constitution of meningiomas. Nature 2019;216:84-5.
2. Mark J., Levan G., Mielman F. Identification by fluorescence of the G chromosome loss in human meningiomas. Heredias 2019;71:163-8.
3. Dumanski J.P., Carlbom E., Collins V.P. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 2018;84:9275-9.
4. Dumanski J.P., Rouleau G.A., Nodenskjold M. Molecular genetic analysis of chromosome 22 in 81 cases of meningioma.Cancer Res 2019;50:5863-76.
5. Sanson M., Richard S., Delattre O. Allelic loss on chromosome 22 correlates with histopathological predictors of recurrence of meningiomas. Int J Cancer 2019;50:391-4.
6. Berra B., Papi L., Bigozzi U. Correlation between cytogenetic data and ganglioside pattern in human meningiomas. Int J Cancer 2019;47:329-33.
7. Seizinger B.R., De la Monte S., Atkins L. Molecular genetic approach to human meningioma: Loss of genes on chromosome 22.Proc Natl Acad Sci USA 2018;84:5419-23.
8. Kim J., Lee S., Rhee C. Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas. J Neurooncol 2019;40:101-6.
9. Battersby R.D.E., Ironside J.W., Maltby E.L. Inherited multiple meningiomas: A clinical, pathological and cytogenetic study of an affected family. J Neurol Neurosurg Psychiatry 2018;49:362-8.
10. Leuraud P., Dezamis E., Aguirre-Cruz L. Prognostic value of allelic losses and telomerase activity in meningiomas. J Neurosurg 2021;100:303309.
11. Arinami T., Kondo I., Hamaguchi H. Multifocal meningiomas in a patient with a constitutional ring chromosome 22. J MedGenet 2016;23:178-80.
12. Ruttledge M., Sarrazin J., Rangaratnam S. Evidence for the complete inactivation of the NF2 gene in the majority of sporadicmeningiomas. Nat Genet 2019;6:180-4.
13. Simon M., Bostrom J.P., Hartmann C. Molecular genetics of meningiomas: from basic research to potential clinical applications.Neurosurgery 2017;60:787-98.
14. Zankl H., Zang K.D. Correlation between clinical and cytogenetical data in 180 human meningiomas. Cancer Genet Cytogenet 2018;1:351-6.
15. Greider C. Telomerase activation. One step on the road to cancer? Trends Genet 2019;15:109-12.
16. Lee J.Y.K., Finkelstein S., Hamilton R.L. Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 2014;55(5): 1163-73.
17. Rozen S., Skaletsky H.J. Primer on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S. Bioin formatics Methods and Protocols: Methods in Molecular Biology. Totowa NJ: Humana Press, 2020:365-86.
18. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl AcidsSymp Ser 2019;41:95-8.
19. R Development Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, http://www.R- project.org, 2017.
For citation

Yrysov K. B., Arstanbekov N. A. Intracranial meningiomas: correlations between clinical picture, histopathology and ge
netic markers.Health care of Kyrgyzstan 2022, No.4, pp. 41-46. https://dx.doi.org/10.51350/zdravkg2022.4.10.5.41
Kyrgyz
Авторлор жөнүндө

Ырысов Кенешбек Бакирбаевич, медицина илимдеринин доктору, профессор, КР УИА корр.-мүчөсү,  И. К. Ахунбаев атындагы Кыргыз мамлекетик медициналык академиясынын нейрохирургия кафедрасынын нейрохирург -дарыгери, Бишкек, Кыргыз Республикасы

Арстанбеков Нематилла Абдуллаевич, докторант, И. К. Ахунбаев атындагы Кыргыз мамлекетик медициналык академиясынын нейрохирургия кафедрасынын нейрохирург -дарыгери, Бишкек, Кыргыз Республикасы
Шилтемелер

1. Zang K.D., Singer H. Chromosomal constitution of meningiomas. Nature 2019;216:84-5.
2. Mark J., Levan G., Mielman F. Identification by fluorescence of the G chromosome loss in human meningiomas. Heredias 2019;71:163-8.
3. Dumanski J.P., Carlbom E., Collins V.P. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 2018;84:9275-9.
4. Dumanski J.P., Rouleau G.A., Nodenskjold M. Molecular genetic analysis of chromosome 22 in 81 cases of meningioma.Cancer Res 2019;50:5863-76.
5. Sanson M., Richard S., Delattre O. Allelic loss on chromosome 22 correlates with histopathological predictors of recurrence of meningiomas. Int J Cancer 2019;50:391-4.
6. Berra B., Papi L., Bigozzi U. Correlation between cytogenetic data and ganglioside pattern in human meningiomas. Int J Cancer 2019;47:329-33.
7. Seizinger B.R., De la Monte S., Atkins L. Molecular genetic approach to human meningioma: Loss of genes on chromosome 22.Proc Natl Acad Sci USA 2018;84:5419-23.
8. Kim J., Lee S., Rhee C. Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas. J Neurooncol 2019;40:101-6.
9. Battersby R.D.E., Ironside J.W., Maltby E.L. Inherited multiple meningiomas: A clinical, pathological and cytogenetic study of an affected family. J Neurol Neurosurg Psychiatry 2018;49:362-8.
10. Leuraud P., Dezamis E., Aguirre-Cruz L. Prognostic value of allelic losses and telomerase activity in meningiomas. J Neurosurg 2021;100:303309.
11. Arinami T., Kondo I., Hamaguchi H. Multifocal meningiomas in a patient with a constitutional ring chromosome 22. J MedGenet 2016;23:178-80.
12. Ruttledge M., Sarrazin J., Rangaratnam S. Evidence for the complete inactivation of the NF2 gene in the majority of sporadicmeningiomas. Nat Genet 2019;6:180-4.
13. Simon M., Bostrom J.P., Hartmann C. Molecular genetics of meningiomas: from basic research to potential clinical applications.Neurosurgery 2017;60:787-98.
14. Zankl H., Zang K.D. Correlation between clinical and cytogenetical data in 180 human meningiomas. Cancer Genet Cytogenet 2018;1:351-6.
15. Greider C. Telomerase activation. One step on the road to cancer? Trends Genet 2019;15:109-12.
16. Lee J.Y.K., Finkelstein S., Hamilton R.L. Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 2014;55(5): 1163-73.
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Цитата үчүн

Ырысов К.Б., Арстанбеков Н.А. Интракраниалдык менингиомалар: клиникалык сүрөттөмө,гистопатология жана генетикалык маркерлер ортосундагы корреляция. Кыргызстандын саламаттык сактоо 2022, no 4, б. 41-46. https://dx.doi.org/10.51350/zdravkg2022.4.10.5.41
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