Health care of Kyrgyzstan
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A clinical case of transverse myelitis complicated by refractory intestinal dysfunction, which led to intestinal perforation and death

https://dx.doi.org/10.51350/zdravkg2024.2.6.9.71.77
A clinical case of transverse myelitis complicated by refractory intestinal dysfunction, which led to intestinal perforation and death
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Abstract About the authors References

Abstract

Introduction. Transverse myelitis is an extremely rare neuroinflammatory disorder. Almost half of the affected patients develop para- or tetraplegia associated with urinary tract and intestinal dysfunction. It is believed that intestinal dysfunction can be treated with dietary nutrition and laxatives. The purpose of the study. Analysis of anamnestic, clinical, laboratory and instrumental data on the medical history of a 50-year-old woman with diagnosed transverse myelitis complicated by refractory intestinal dysfunction, which led to intestinal perforation and death. Materials and methods. The diagnosis of the disease was based on clinical data, the results of instrumental and laboratory studies. The treatment was carried out with hormonal and anticholinesterase drugs. Results. The importance of timely diagnosis of intestinal dysfunction and neurogenic bladder in transverse myelitis is indicated . Conclusion. Although constipation is considered benign in transverse myelitis, complicated forms of constipation in people with transverse myelitis can be fatal.

About the authors

Алымжан уулу Болотбек, ассистент кафедры неврологии с курсом медицинской генетики Кыргызской государственной медицинской академии им. И.К. Ахунбаева, Бишкек, Кыргызская Республика

Исраилова Айчолпон Тагайбековна, ассистент кафедры Неврологии и клинической генетики Кыргызской государственной медицинской академии им. И.К. Ахунбаева, Бишкек, Кыргызская Республика
Жолдошев Эмир Кылычбекович, завуч кафедры кафедры Неврологии и клинической генетики Кыргызской государственной медицинской академии им. И.К. Ахунбаева, Бишкек, Кыргызская Республика

Alymjan uulu Bolotbek, assistant at the Department of Neurology with a course in medical genetics, Kyrgyz State Medical Academy named after I.K. Akhunbaeva, Bishkek, Kyrgyz Republic
Israilova Aicholpon Tagaybekovna, assistant of the Department of Neurology and Clinical Genetics of the Kyrgyz State Medical Academy named after I.K. Akhunbaeva, Bishkek, Kyrgyz Republic

Zholdoshev Emir Kylychbekovich, Head of the Department of Neurology and Clinical Genetics of the Kyrgyz State Medical Academy named after I.K. Akhunbaeva, Bishkek, Kyrgyz Republic

Алымжан уулу Болотбек, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын медициналык генетика курсу менен неврология кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы

Исраилова Айчолпон Тагайбековна, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын неврология жана клиникалык генетика кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы

Эмир Кылычбекович Жолдошев, И.К. Ахунбаев атындагы  Кыргыз мамлекеттик медициналык академиясынын неврология жана клиникалык генетика кафедрасынын башчысы, Бишкек, Кыргыз Республикасы

References

1. Jeffery DR, Mandler RN, Davis LE. Transverse Myelitis: Retrospective Analysis of 33 Cases, With Differentiation of
Cases Associated With Multiple Sclerosis and Parainfectious Events. Arch Neurol. 1993;50(5):532–535. doi:10.1001/archneur.1993.00540050074019
2. Krishnan C, Kaplin AI, Pardo CA, Kerr DA, Keswani SC. Demyelinating disorders: update on transverse myelitis.Curr
Neurol Neurosci Rep. 2006 May;6(3):236-43. doi: 10.1007/s11910-006-0011-1. PMID: 16635433.
3. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A,
Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG;
International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum
disorders. Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729. Epub 2015 Jun 19.PMID: 260
92914; PMCID: PMC4515040.
4. Krishnan C, Kaplin AI, Pardo CA, et al.. Demyelinating disorders: update on transverse myelitis. Curr Neurol Neurosci
Rep 2006;6:236–43. 10.1007/s11910-006-0011-1.
5. Johns JS, Krogh K, Ethans K, et al..Pharmacological management of neurogenic bowel dysfunction after spinal cord
injury and multiple sclerosis:a systematic review and clinical implications. J Clin Med 2021;10:882.10.3390/jcm1004088
2.
6. Emmanuel A. Neurogenic bowel dysfunction. F1000Res.2019 Oct 28;8:F1000 Faculty Rev-1800. doi: 10.12688/f1000
research.20529.1. PMID:31700610; PMCID: PMC6820819.
7. Hughes M. Bowel management in spinal cord injury patients. Clin Colon Rectal Surg 2014;27:113–5. 10.1055/s-0034-
1383904
8. Alavi K, Poylin V, Davids JS, et al.. The American Society of colon and rectal surgeons clinical practice guidelines for
the management of colonic volvulus and acute colonic pseudo-obstruction. Dis Colon Rectum 2021;64:1046–57.10.
1097 /DCR.0000000000002159

1. Jeffery DR, Mandler RN, Davis LE. Transverse Myelitis: Retrospective Analysis of 33 Cases, With Differentiation of
Cases Associated With Multiple Sclerosis and Parainfectious Events. Arch Neurol. 1993;50(5):532–535. doi:10.1001/archneur.1993.00540050074019
2. Krishnan C, Kaplin AI, Pardo CA, Kerr DA, Keswani SC. Demyelinating disorders: update on transverse myelitis.Curr
Neurol Neurosci Rep. 2006 May;6(3):236-43. doi: 10.1007/s11910-006-0011-1. PMID: 16635433.
3. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A,
Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG;
International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum
disorders. Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729. Epub 2015 Jun 19.PMID: 260
92914; PMCID: PMC4515040.
4. Krishnan C, Kaplin AI, Pardo CA, et al.. Demyelinating disorders: update on transverse myelitis. Curr Neurol Neurosci
Rep 2006;6:236–43. 10.1007/s11910-006-0011-1.
5. Johns JS, Krogh K, Ethans K, et al..Pharmacological management of neurogenic bowel dysfunction after spinal cord
injury and multiple sclerosis:a systematic review and clinical implications. J Clin Med 2021;10:882.10.3390/jcm1004088
2.
6. Emmanuel A. Neurogenic bowel dysfunction. F1000Res.2019 Oct 28;8:F1000 Faculty Rev-1800. doi: 10.12688/f1000
research.20529.1. PMID:31700610; PMCID: PMC6820819.
7. Hughes M. Bowel management in spinal cord injury patients. Clin Colon Rectal Surg 2014;27:113–5. 10.1055/s-0034-
1383904
8. Alavi K, Poylin V, Davids JS, et al.. The American Society of colon and rectal surgeons clinical practice guidelines for
the management of colonic volvulus and acute colonic pseudo-obstruction. Dis Colon Rectum 2021;64:1046–57.10.
1097 /DCR.0000000000002159

1. Jeffery DR, Mandler RN, Davis LE. Transverse Myelitis: Retrospective Analysis of 33 Cases, With Differentiation of
Cases Associated With Multiple Sclerosis and Parainfectious Events. Arch Neurol. 1993;50(5):532–535. doi:10.1001/archneur.1993.00540050074019
2. Krishnan C, Kaplin AI, Pardo CA, Kerr DA, Keswani SC. Demyelinating disorders: update on transverse myelitis.Curr
Neurol Neurosci Rep. 2006 May;6(3):236-43. doi: 10.1007/s11910-006-0011-1. PMID: 16635433.
3. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A,
Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG;
International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum
disorders. Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729. Epub 2015 Jun 19.PMID: 260
92914; PMCID: PMC4515040.
4. Krishnan C, Kaplin AI, Pardo CA, et al.. Demyelinating disorders: update on transverse myelitis. Curr Neurol Neurosci
Rep 2006;6:236–43. 10.1007/s11910-006-0011-1.
5. Johns JS, Krogh K, Ethans K, et al..Pharmacological management of neurogenic bowel dysfunction after spinal cord
injury and multiple sclerosis:a systematic review and clinical implications. J Clin Med 2021;10:882.10.3390/jcm1004088
2.
6. Emmanuel A. Neurogenic bowel dysfunction. F1000Res.2019 Oct 28;8:F1000 Faculty Rev-1800. doi: 10.12688/f1000
research.20529.1. PMID:31700610; PMCID: PMC6820819.
7. Hughes M. Bowel management in spinal cord injury patients. Clin Colon Rectal Surg 2014;27:113–5. 10.1055/s-0034-
1383904
8. Alavi K, Poylin V, Davids JS, et al.. The American Society of colon and rectal surgeons clinical practice guidelines for
the management of colonic volvulus and acute colonic pseudo-obstruction. Dis Colon Rectum 2021;64:1046–57.10.
1097 /DCR.0000000000002159

 

 

Keywords
Complications , Transverse myelitis , Intestinal dysfunction , Intestinal perforation , Fatal outcome
Для цитирования

Алымжан уулу Болотбек, Исраилова А.Т. Жолдошев Э.К. Клинический случай поперечного миелита, осложненного рефракторной кишечной дисфункцией, приведшей к перфорации кишечника и летальному исходу. Научно-практический журнал «Здравоохранение Кыргызстана» 2024, № 2, с. 71-77. https://dx.doi.org/10.51350/zdravkg2024.2.6.9.71.77
For citation

Alymjan uulu Bolotbek, Israilova A.T., Zholdoshev E.K. A clinical case of transverse myelitis complicated by refractory intestinal dysfunction, which led to in testinal perforation and death.Scientific practical journal “Health care of
Kyrgyzstan” 2024, No.2, p. 71-77. https://dx.doi.org/10.51350/zdravkg2024.2.6.9.71.77
Цитата үчүн

Алымжан уулу Болотбек, Исраилова А.Т. Жолдошев Э.К. Рефрактордук ичеги дисфункциясы менен татаалдашкан, ичегинин тешилишине жана өлүмгө алып келген туурасынан кеткен миелиттин клиникалык учуру. "Кыргызстандын саламаттык сактоо" илимий-практикалык журналы 2024, № 2, б. 71-77.  https://dx.doi.org/10.51350/zdravkg2024.2.6.9.71.77
Authors Alymjan uulu Bolotbek, Israilova A.T., Turdumambetova M.A.
Link doi.org https://dx.doi.org/10.51350/zdravkg2024.2.6.9.71.77
Pages 71-77
Keywords Complications, Transverse myelitis, Intestinal dysfunction, Intestinal perforation, Fatal outcome
Russian
Об авторах

Алымжан уулу Болотбек, ассистент кафедры неврологии с курсом медицинской генетики Кыргызской государственной медицинской академии им. И.К. Ахунбаева, Бишкек, Кыргызская Республика

Исраилова Айчолпон Тагайбековна, ассистент кафедры Неврологии и клинической генетики Кыргызской государственной медицинской академии им. И.К. Ахунбаева, Бишкек, Кыргызская Республика
Жолдошев Эмир Кылычбекович, завуч кафедры кафедры Неврологии и клинической генетики Кыргызской государственной медицинской академии им. И.К. Ахунбаева, Бишкек, Кыргызская Республика
Полный текст

PDF (RUS)
Список литературы

1. Jeffery DR, Mandler RN, Davis LE. Transverse Myelitis: Retrospective Analysis of 33 Cases, With Differentiation of
Cases Associated With Multiple Sclerosis and Parainfectious Events. Arch Neurol. 1993;50(5):532–535. doi:10.1001/archneur.1993.00540050074019
2. Krishnan C, Kaplin AI, Pardo CA, Kerr DA, Keswani SC. Demyelinating disorders: update on transverse myelitis.Curr
Neurol Neurosci Rep. 2006 May;6(3):236-43. doi: 10.1007/s11910-006-0011-1. PMID: 16635433.
3. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A,
Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG;
International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum
disorders. Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729. Epub 2015 Jun 19.PMID: 260
92914; PMCID: PMC4515040.
4. Krishnan C, Kaplin AI, Pardo CA, et al.. Demyelinating disorders: update on transverse myelitis. Curr Neurol Neurosci
Rep 2006;6:236–43. 10.1007/s11910-006-0011-1.
5. Johns JS, Krogh K, Ethans K, et al..Pharmacological management of neurogenic bowel dysfunction after spinal cord
injury and multiple sclerosis:a systematic review and clinical implications. J Clin Med 2021;10:882.10.3390/jcm1004088
2.
6. Emmanuel A. Neurogenic bowel dysfunction. F1000Res.2019 Oct 28;8:F1000 Faculty Rev-1800. doi: 10.12688/f1000
research.20529.1. PMID:31700610; PMCID: PMC6820819.
7. Hughes M. Bowel management in spinal cord injury patients. Clin Colon Rectal Surg 2014;27:113–5. 10.1055/s-0034-
1383904
8. Alavi K, Poylin V, Davids JS, et al.. The American Society of colon and rectal surgeons clinical practice guidelines for
the management of colonic volvulus and acute colonic pseudo-obstruction. Dis Colon Rectum 2021;64:1046–57.10.
1097 /DCR.0000000000002159
Для цитирования

Алымжан уулу Болотбек, Исраилова А.Т. Жолдошев Э.К. Клинический случай поперечного миелита, осложненного рефракторной кишечной дисфункцией, приведшей к перфорации кишечника и летальному исходу. Научно-практический журнал «Здравоохранение Кыргызстана» 2024, № 2, с. 71-77. https://dx.doi.org/10.51350/zdravkg2024.2.6.9.71.77
English
About authors

Alymjan uulu Bolotbek, assistant at the Department of Neurology with a course in medical genetics, Kyrgyz State Medical Academy named after I.K. Akhunbaeva, Bishkek, Kyrgyz Republic
Israilova Aicholpon Tagaybekovna, assistant of the Department of Neurology and Clinical Genetics of the Kyrgyz State Medical Academy named after I.K. Akhunbaeva, Bishkek, Kyrgyz Republic

Zholdoshev Emir Kylychbekovich, Head of the Department of Neurology and Clinical Genetics of the Kyrgyz State Medical Academy named after I.K. Akhunbaeva, Bishkek, Kyrgyz Republic
References

1. Jeffery DR, Mandler RN, Davis LE. Transverse Myelitis: Retrospective Analysis of 33 Cases, With Differentiation of
Cases Associated With Multiple Sclerosis and Parainfectious Events. Arch Neurol. 1993;50(5):532–535. doi:10.1001/archneur.1993.00540050074019
2. Krishnan C, Kaplin AI, Pardo CA, Kerr DA, Keswani SC. Demyelinating disorders: update on transverse myelitis.Curr
Neurol Neurosci Rep. 2006 May;6(3):236-43. doi: 10.1007/s11910-006-0011-1. PMID: 16635433.
3. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A,
Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG;
International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum
disorders. Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729. Epub 2015 Jun 19.PMID: 260
92914; PMCID: PMC4515040.
4. Krishnan C, Kaplin AI, Pardo CA, et al.. Demyelinating disorders: update on transverse myelitis. Curr Neurol Neurosci
Rep 2006;6:236–43. 10.1007/s11910-006-0011-1.
5. Johns JS, Krogh K, Ethans K, et al..Pharmacological management of neurogenic bowel dysfunction after spinal cord
injury and multiple sclerosis:a systematic review and clinical implications. J Clin Med 2021;10:882.10.3390/jcm1004088
2.
6. Emmanuel A. Neurogenic bowel dysfunction. F1000Res.2019 Oct 28;8:F1000 Faculty Rev-1800. doi: 10.12688/f1000
research.20529.1. PMID:31700610; PMCID: PMC6820819.
7. Hughes M. Bowel management in spinal cord injury patients. Clin Colon Rectal Surg 2014;27:113–5. 10.1055/s-0034-
1383904
8. Alavi K, Poylin V, Davids JS, et al.. The American Society of colon and rectal surgeons clinical practice guidelines for
the management of colonic volvulus and acute colonic pseudo-obstruction. Dis Colon Rectum 2021;64:1046–57.10.
1097 /DCR.0000000000002159
For citation

Alymjan uulu Bolotbek, Israilova A.T., Zholdoshev E.K. A clinical case of transverse myelitis complicated by refractory intestinal dysfunction, which led to in testinal perforation and death.Scientific practical journal “Health care of
Kyrgyzstan” 2024, No.2, p. 71-77. https://dx.doi.org/10.51350/zdravkg2024.2.6.9.71.77
Kyrgyz
Авторлор жөнүндө

Алымжан уулу Болотбек, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын медициналык генетика курсу менен неврология кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы

Исраилова Айчолпон Тагайбековна, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын неврология жана клиникалык генетика кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы

Эмир Кылычбекович Жолдошев, И.К. Ахунбаев атындагы  Кыргыз мамлекеттик медициналык академиясынын неврология жана клиникалык генетика кафедрасынын башчысы, Бишкек, Кыргыз Республикасы
Шилтемелер

1. Jeffery DR, Mandler RN, Davis LE. Transverse Myelitis: Retrospective Analysis of 33 Cases, With Differentiation of
Cases Associated With Multiple Sclerosis and Parainfectious Events. Arch Neurol. 1993;50(5):532–535. doi:10.1001/archneur.1993.00540050074019
2. Krishnan C, Kaplin AI, Pardo CA, Kerr DA, Keswani SC. Demyelinating disorders: update on transverse myelitis.Curr
Neurol Neurosci Rep. 2006 May;6(3):236-43. doi: 10.1007/s11910-006-0011-1. PMID: 16635433.
3. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A,
Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG;
International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum
disorders. Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729. Epub 2015 Jun 19.PMID: 260
92914; PMCID: PMC4515040.
4. Krishnan C, Kaplin AI, Pardo CA, et al.. Demyelinating disorders: update on transverse myelitis. Curr Neurol Neurosci
Rep 2006;6:236–43. 10.1007/s11910-006-0011-1.
5. Johns JS, Krogh K, Ethans K, et al..Pharmacological management of neurogenic bowel dysfunction after spinal cord
injury and multiple sclerosis:a systematic review and clinical implications. J Clin Med 2021;10:882.10.3390/jcm1004088
2.
6. Emmanuel A. Neurogenic bowel dysfunction. F1000Res.2019 Oct 28;8:F1000 Faculty Rev-1800. doi: 10.12688/f1000
research.20529.1. PMID:31700610; PMCID: PMC6820819.
7. Hughes M. Bowel management in spinal cord injury patients. Clin Colon Rectal Surg 2014;27:113–5. 10.1055/s-0034-
1383904
8. Alavi K, Poylin V, Davids JS, et al.. The American Society of colon and rectal surgeons clinical practice guidelines for
the management of colonic volvulus and acute colonic pseudo-obstruction. Dis Colon Rectum 2021;64:1046–57.10.
1097 /DCR.0000000000002159

 

 
Цитата үчүн

Алымжан уулу Болотбек, Исраилова А.Т. Жолдошев Э.К. Рефрактордук ичеги дисфункциясы менен татаалдашкан, ичегинин тешилишине жана өлүмгө алып келген туурасынан кеткен миелиттин клиникалык учуру. "Кыргызстандын саламаттык сактоо" илимий-практикалык журналы 2024, № 2, б. 71-77.  https://dx.doi.org/10.51350/zdravkg2024.2.6.9.71.77
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