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О роли дефицита витамина D в развитии коморбидных состояний связанных с возрастом

https://dx.doi.org/10.51350/zdravkg20223118123
О роли дефицита витамина D в развитии коморбидных состояний связанных с возрастом
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Аннотация Об авторах Список литературы

Аннотация

Широкий спектр заболеваний, связанных с низким уровнем витамина D, подтверждается растущим объемом исследований в этой области. В настоящее время доступны данные об эндокринной, аутокринной и паракринной активности витамина D, а также об основных детерминантах снижения уровня витамина D у людей. Дефицит витамина D приводит ккоморбидности, нарушению функционирования организма человека, что имеет свои особенности в зависимости от возраста.

Об авторах

Исупова Алена Анатольевна, кандидат медицинских наук, старший преподаватель кафедры дерматовенерологии и фтизиатрии Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика;

Исупов Роман Вячеславович, аспирант, Кыргызско-Российского Славянского университета им. Б.Н.Ельцина, Бишкек,Кыргызская Республика

Isupova Alena Anatolyevna , Candidate of Medical Sciences, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Senior Lecturer of the Department of Dermatovenerology and Phthisiology, Bishkek, Kyrgyz Republic;
Isupov Roman Alekeslavovich, PhD student, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Bishkek, Kyrgyz Republic

Исупова Алена Анатольевна, медицина илимдеринин кандидаты, Б.Н. Ельцин атындагы Кыргыз-Россия славиян университетинун тери-венерология жана фтизиатрия кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы;

Исупов Роман Вячеславович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин аспиранты, Бишкек, Кыргыз Республикасы

Список литературы

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1. Zmijewski MA. Vitamin D and Human Health. Int J Mol Sci. 2019;20(1):145. Published 2019 Jan 3. doi:10.3390/ijms20010145
2. Muscogiuri G, Altieri B, Annweiler C, Balercia G, Pal HB, Boucher BJ, Cannell JJ, Foresta C, Grübler MR, Kotsa K, Mascitelli L, März W, Orio F, Pilz S, Tirabassi G, Colao A. Vitamin D and chronic diseases: the current state of the art. Arch Toxicol. 2017; 91(1):97-107. doi: 10.1007/s00204-016-1804-x
3. Giustina A, Adler RA, Binkley N, Bouillon R, Ebeling PR, Lazaretti-Castro M, Marcocci C, Rizzoli R, Sempos CT, Bilezikian JP.Controversies in vitamin D: summary statement from an international conference. J Clin Endocrinol Metab. 2019;104(2):234–240. doi: 10.1210/jc.2018-01414.
4. Roth DE, Abrams SA, Aloia J, et al. Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in lowand middle-income countries. Ann N Y Acad Sci. 2018;1430(1):44-79. doi:10.1111/nyas.13968
5. LeFevre M.L., Force U.S. Screening for vitamin D deficiency in adults: U.S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 2015;162:133–140. doi: 10.7326/M14-2450.
6. Isupova A. A., Isupov R.V. Determinanty pokazatelej syvorotochnogo 25 (OH) D korennyh zhitelej Kyrgyzstana. Zdravoohranenie Kyrgyzstana. – 2021. – №4. – S. 34-39. – DOI 10.51350/zdravkg2021124334.
7. Siddiqee MH, Bhattacharjee B, Siddiqi UR, Rahman MM. High burden of hypovitaminosis D among the children and adolescents in South Asia: a systematic review and meta-analysis. J Health Popul Nutr. 2022;41(1):10. Published 2022 Mar 17.doi:10.1186/s41043-022-00287-w.
8. Jeyakumar A, Shinde V. A systematic review and meta-analysis of prevalence of vitamin D deficiency among adolescent girls in selected Indian states. Nutr Health. 2019;25(1):61–70. doi: 10.1177/0260106018805360.
9. Norman A. Vitamin D. In: Bowman B.A., Russel R.E., editors. Present knowledge of nutrition. 8th ed. ILSI Press; Washington, DC: 2001. [chapter 13]
10. Vanchinathan V., Lim H.W. A dermatologist’s perspective on vitamin D. Mayo Clin Proc. 2012;87:372–380
11. Haussler MR, Haussler CA, Jurutka PW, Thompson PD, Hsieh JC, Remus LS, Selznick SH, Whitfield GK. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997 Sep;154 Suppl:S57-73. PMID: 9379138
12. Haussler MR, et al. New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone. Bone. 1995;17:33S–38S.
13. Wang Y, Zhu J, DeLuca HF. Where is the vitamin D receptor? Arch Biochem Biophys. 2012;523(1):123–133.
doi: 10.1016/j.abb.2012.04.001
14. Holick MF, Schnoes HK, DeLuca HF. Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Natl Acad Sci U S A. 1971;68(4):803–804. doi: 10.1073/pnas.68.4.803.
15. Pike JW, Meyer MB, Lee SM, Onal M, Benkusky NA. The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights. J Clin Invest. 2017;127(4):1146-1154. doi:10.1172/JCI88887
16. Brenner M, Hearing VJ. The protective role of melanin against UV damage in human skin. Photochem Photobiol. 2008; 84(3):539-549. doi:10.1111/j.1751-1097.2007.00226.x
17. O'Sullivan F, Raftery T, van Weele M, van Geffen J, McNamara D, O'Morain C, et al. Sunshine is an important determinant of vitamin D status even among high-dose supplement users: secondary analysis of a randomized controlled trial in Crohn's disease patients. Photochem Photobiol. 2019;95(4):1060–1067. doi: 10.1111/php.13086.
18. McCullough PJ, McCullough WP, Lehrer D, Travers JB, Repas SJ. Oral and Topical Vitamin D, Sunshine, and UVB Photothera py Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-Hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications. Nutrients. 2021;13(5):1511. Published 2021 Apr 29. doi:10.3390/nu13051511
19. Webb AR, DeCosta BR, Holick MF. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. Journal of Clinical Endocrinology and Metabolism. 1989;68(5):882–887.
20. Brzeminski P, Fabisiak A, Slominski RM, Kim TK, Janjetovic Z, Podgorska E, Song Y, Saleem M, Reddy SB, Qayyum S, Song Y,Tuckey RC, Atigadda V, Jetten AM, Sicinski RR, Raman C, Slominski AT. Chemical synthesis, biological activities and action on nuclear receptors of 20S(OH)D3, 20S,25(OH)2D3, 20S,23S(OH)2D3 and 20S,23R(OH)2D3. Bioorg Chem. 2022 Apr;121:105660. doi: 10.1016/j.bioorg.2022.105660
21. Jiménez-sousa MÁ, Martínez I, Medrano LM. Vitamin D in human immunodeficiency virus infection: influence on immunity and disease. Front Immunol. (2018) 9:458. doi: 10.3389/fimmu.2018.00458 Bikle D.D. Vitamin D metabolism, mechanism of action, and clinical applications. Chem. Biol. 2014;21:319–329. doi: 10.1016/j.chembiol.2013.12.016
22. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA. Cloning of human 25-hydroxyvitamin D-1
alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1997 Dec;11(13):1961-70. doi: 10.1210/mend.11.13.0035.] Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinol. 2013;5(1):51-108. doi:10.4161/derm.24494
23. Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F,Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V. Effectiveness and safety of vitamin D in relation tobone health. Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. PMID: 18088161; PMCID: PMC4781354.
24. Minisola S, Colangelo L, Pepe J, Diacinti D, Cipriani C, Rao SD. Osteomalacia and Vitamin D Status: A Clinical Update 2020. JBMR Plus. 2020 Dec 21;5(1):e10447. doi: 10.1002/jbm4.10447
25. Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O. Vitamin D-related changes in physical performance: a systematic review. J Nutr Health Aging. 2009;13(10):893–898
26. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, et al. Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial. JAMA Intern Med. 2016;176(2):175–183
27. Mayo BC, Massel DH, Yacob A, Narain AS, Hijji FY, Jenkins NW, Parrish JM, Modi KD, Long WW, Hrynewycz NM,
Brundage TS, Singh K. A Review of Vitamin D in Spinal Surgery: Deficiency Screening, Treatment, and Outcomes. Int J
Spine Surg. 2020 Jun 30;14(3):447-454. doi: 10.14444/7059.]
28. Morris HA, Anderson PH. Autocrine and paracrine actions of vitamin d. Clin Biochem Rev. 2010 Nov;31(4):129-38.
29. Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. doi: 10.2215/CJN.01160308.
30. Mostafa WZ, Hegazy RA. Vitamin D and the skin: Focus on a complex relationship: A review. J Adv Res. 2015;6(6):793-804. doi:10.1016/j.jare.2014.01.011
31. Morris HA. Vitamin D activities for health outcomes. Ann Lab Med. 2014 May;34(3):181-6. doi: 10.3343/alm.2014.34.3.181
32. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–81.
33. Cuppari L, Garcia-Lopes MG. Hypovitaminosis D in chronic kidney disease patients: prevalence and treatment. J Ren Nutr.2009;19:38–43.
34. Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. doi: 10.2215/CJN.01160308
35. Medrano M., Carrillo-Cruz E., Montero I., Perez-Simon J.A. Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. Int. J. Mol. Sci. 2018;19:2663. doi: 10.3390/ijms19092663
36. Gruber-Bzura B.M.Vitamin D and Influenza-Prevention or Therapy? Int. J. Mol. Sci. 2018;19:2419. doi: 10.33 90/ijms 19082419
37. Carlberg C. Vitamin D Signaling in the Context of Innate Immunity: Focus on Human Monocytes. Front. Immunol. 2019;10:2211. doi: 10.3389/fimmu.2019.02211
38. Huang SJ, Wang XH, Liu ZD, et al. Vitamin D deficiency and the risk of tuberculosis: a meta-analysis. Drug Des Devel Ther. 2017;11:91–102. doi: 10.2147/DDDT.S79870
39. Jiménez-sousa MÁ, Martínez I, Medrano LM. Vitamin D in human immunodeficiency virus infection: influence on immunity and disease. Front Immunol. 2018; 9:458. doi: 10.3389/fimmu.2018.00458
40. Eyles DW. Vitamin D: Brain and Behavior. JBMR Plus. 2020 Oct 18;5(1):e10419. doi: 10.1002/jbm4.10419
41. Ali A, Cui X, Eyles D. Developmental vitamin D deficiency and autism: Putative pathogenic mechanisms. J Steroid Biochem Mol Biol. 2018 Jan;175:108-118. doi: 10.1016/j.jsbmb.2016.12.018.
42. Berridge MJ. Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia). Am J Physiol Cell Physiol. 2018 Feb 1;314(2):C135-C151. doi: 10.1152/ ajpcell. 00188.2017
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47. Halcox JP, Deanfield JE. Childhood origins of endothelial dysfunction. Heart. 2005;91(10):1272-1274.
doi:10.1136/hrt.2005.061317
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50. Blair MJ, Jones JD, Woessner AE, Quinn KP. Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging. Adv Wound Care (New Rochelle). 2020;9(3):127-143. doi:10.1089/wound.2019.102151. D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222-12248. Published 2013 Jun 7. doi:10.3390/ijms140612222
52. Slominski A.T., Janjetovic Z., Kim T.K., Wasilewski P., Rosas S., Hanna S., Sayre R.M., Dowdy J.C., Li W., Tuckey R.C. Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J. Steroid Biochem. Mol. Biol. 2015;148:52–63. doi: 10.1016/j.jsbmb.2015.01.014
53. Slominski AT, Kim TK, Li W, Yi AK, Postlethwaite A, Tuckey RC. The role of CYP11A1 in the production of vitamin D
metabolites and their role in the regulation of epidermal functions. J Steroid Biochem Mol Biol. 2013
54. Dixon KM, Norman AW, Sequeira VB, Mohan R, Rybchyn MS, Reeve VE, Halliday GM, Mason RS. 1alpha,25(OH)(2)-vitamin D and a nongenomic vitamin D analogue inhibit ultraviolet radiation-induced skin carcinogenesis. Cancer Prev Res(Phila) 2011;4:1485–1494.
55. Grant W.B. The effect of solar UVB doses and vitamin D production, skin cancer action spectra, and smoking in explaining links between skin cancers and solid tumours. Eur. J. Cancer. 2008;44:12–15. doi: 10.1016/j.ejca. 2007. 09. 009
56. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76:1536–8. doi: 10.1172/JCI112134
57. Reichrath J. Unravelling of hidden secrets: The role of vitamin D in skin aging. Dermatoendocrinol. 2012;4(3):241-244.doi:10.4161/derm.21312
58. Warwick, T., Schulz, M.H., Günther, S. et al. A hierarchical regulatory network analysis of the vitamin D induced transcrip tome reveals novel regulators and complete VDR dependency in monocytes. Sci Rep 11, 6518 (2021). https://doi.org/10.1038/s41598-021-86032-5
59. Haussler MR, Haussler CA, Whitfield GK, Hsieh JC, Thompson PD, Barthel TK, et al. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging. J Steroid Biochem Mol Biol. 2010;121:88–97. doi: 10.1016/j.jsbmb.2010.03.019
60. Grabowska W, Sikora E & Bielak-Zmijewska A (2017). Sirtuins, a promising target in slowing down the ageing process. Biogerontology 18, 447–476.
61. Gonzalo S, Kreienkamp R & Askjaer P (2017). Hutchinson-Gilford progeria syndrome: a premature aging disease caused by LMNA gene mutations. Ageing Res Rev 33, 18–29
62. Bocheva G, Slominski RM, Slominski AT. The Impact of Vitamin D on Skin Aging. Int J Mol Sci. 2021 Aug 23;22(16):9097.doi: 10.3390/ijms22169097

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42. Berridge MJ. Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia). Am J Physiol Cell Physiol. 2018 Feb 1;314(2):C135-C151. doi: 10.1152/ ajpcell. 00188.2017
43. Anjum I, Jaffery SS, Fayyaz M, Samoo Z, Anjum S. The Role of Vitamin D in Brain Health: A Mini Literature Review.
Cureus. 2018;10(7):e2960. Published 2018 Jul 10. doi:10.7759/cureus.2960
44. Yiu Y.F., Chan Y.H., Yiu K.H., Siu C.W., Li S.W., Wong L.Y., Lee S.W., Tam S., Wong E.W., Cheung B.M., et al. Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 2011;96:E830–E835. doi: 10.1210/jc.2010-2212
45. Latic N, Erben RG. Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure. Int J Mol Sci. 2020;21(18):6483. Published 2020 Sep 4. doi:10.3390/ijms21186483
46. Scragg R., Jackson R., Holdaway I.M., Lim T., Beaglehole R. Myocardial Infarction Is Inversely Associated With Plasma 25-Hydroxyvitamin D3 Levels: A Community-Based Study. Int. J. Epidemiol. 1990;19:559–563. doi: 10.1093/ije/19.3.559
47. Halcox JP, Deanfield JE. Childhood origins of endothelial dysfunction. Heart. 2005;91(10):1272-1274.
doi:10.1136/hrt.2005.061317
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49. Kim DH, Meza CA, Clarke H, Kim JS, Hickner RC. Vitamin D and Endothelial Function. Nutrients. 2020;12(2):575. Published 2020 Feb 22. doi:10.3390/nu12020575
50. Blair MJ, Jones JD, Woessner AE, Quinn KP. Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging. Adv Wound Care (New Rochelle). 2020;9(3):127-143. doi:10.1089/wound.2019.102151. D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222-12248. Published 2013 Jun 7. doi:10.3390/ijms140612222
52. Slominski A.T., Janjetovic Z., Kim T.K., Wasilewski P., Rosas S., Hanna S., Sayre R.M., Dowdy J.C., Li W., Tuckey R.C. Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J. Steroid Biochem. Mol. Biol. 2015;148:52–63. doi: 10.1016/j.jsbmb.2015.01.014
53. Slominski AT, Kim TK, Li W, Yi AK, Postlethwaite A, Tuckey RC. The role of CYP11A1 in the production of vitamin D
metabolites and their role in the regulation of epidermal functions. J Steroid Biochem Mol Biol. 2013
54. Dixon KM, Norman AW, Sequeira VB, Mohan R, Rybchyn MS, Reeve VE, Halliday GM, Mason RS. 1alpha,25(OH)(2)-vitamin D and a nongenomic vitamin D analogue inhibit ultraviolet radiation-induced skin carcinogenesis. Cancer Prev Res(Phila) 2011;4:1485–1494.
55. Grant W.B. The effect of solar UVB doses and vitamin D production, skin cancer action spectra, and smoking in explaining links between skin cancers and solid tumours. Eur. J. Cancer. 2008;44:12–15. doi: 10.1016/j.ejca. 2007. 09. 009
56. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76:1536–8. doi: 10.1172/JCI112134
57. Reichrath J. Unravelling of hidden secrets: The role of vitamin D in skin aging. Dermatoendocrinol. 2012;4(3):241-244.doi:10.4161/derm.21312
58. Warwick, T., Schulz, M.H., Günther, S. et al. A hierarchical regulatory network analysis of the vitamin D induced transcrip tome reveals novel regulators and complete VDR dependency in monocytes. Sci Rep 11, 6518 (2021). https://doi.org/10.1038/s41598-021-86032-5
59. Haussler MR, Haussler CA, Whitfield GK, Hsieh JC, Thompson PD, Barthel TK, et al. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging. J Steroid Biochem Mol Biol. 2010;121:88–97. doi: 10.1016/j.jsbmb.2010.03.019
60. Grabowska W, Sikora E & Bielak-Zmijewska A (2017). Sirtuins, a promising target in slowing down the ageing process. Biogerontology 18, 447–476.
61. Gonzalo S, Kreienkamp R & Askjaer P (2017). Hutchinson-Gilford progeria syndrome: a premature aging disease caused by LMNA gene mutations. Ageing Res Rev 33, 18–29
62. Bocheva G, Slominski RM, Slominski AT. The Impact of Vitamin D on Skin Aging. Int J Mol Sci. 2021 Aug 23;22(16):9097.doi: 10.3390/ijms22169097

Ключевые слова
Обеспеченность компонентами крови , кожа , остеопороз , качество костной ткани , 25(OH)D , дефицит витамина Д , VDR , эндокринная , аутокринная и паракринная функция витамина D , человек , иммунитет , коморбидность
Для цитирования

Исупова А.А. , Исупов Р.В. О роли дефицита витамина D в развитии коморбидных состояний связанных с возрастом. Здравоохранение Кыргызстана 2022, № 1,с.123-129. 
https://dx.doi.org/10.51350/zdravkg20223118123
For citation

Isupova A.A., Isupov R.V.On the role of vitamin D defiiency in the development of age-related comorbid conditions.Health care of Kyrgyzstan 2022, No.1, pp. 123-129. 
https://dx.doi.org/10.51350/zdravkg20223118123
Цитата үчүн

Исупова А.А. , Исупов Р.В. Куракка байланышкан комоорбид абалдарынын өнүгүшүндө D витамининин жетишсиздигинин ролу жөнүндө. Кыргызстандын саламаттык сактоо 2022, № 1,
с.123-129. https://dx.doi.org/10.51350/zdravkg20223118123
Авторы Исупова А.А., Исупов Р.В.
Ссылка doi.org https://dx.doi.org/10.51350/zdravkg20223118123
Страницы 123-129
Ключевые слова Обеспеченность компонентами крови, кожа, остеопороз, качество костной ткани, 25(OH)D, дефицит витамина Д, VDR, эндокринная, аутокринная и паракринная функция витамина D, человек, иммунитет, коморбидность
Русский
Об авторах

Исупова Алена Анатольевна, кандидат медицинских наук, старший преподаватель кафедры дерматовенерологии и фтизиатрии Кыргызско-Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская Республика;

Исупов Роман Вячеславович, аспирант, Кыргызско-Российского Славянского университета им. Б.Н.Ельцина, Бишкек,Кыргызская Республика
Полный текст

PDF (RUS)
Список литературы

1. Zmijewski MA. Vitamin D and Human Health. Int J Mol Sci. 2019;20(1):145. Published 2019 Jan 3. doi:10.3390/ijms20010145
2. Muscogiuri G, Altieri B, Annweiler C, Balercia G, Pal HB, Boucher BJ, Cannell JJ, Foresta C, Grübler MR, Kotsa K, Mascitelli L, März W, Orio F, Pilz S, Tirabassi G, Colao A. Vitamin D and chronic diseases: the current state of the art. Arch Toxicol. 2017; 91(1):97-107. doi: 10.1007/s00204-016-1804-x
3. Giustina A, Adler RA, Binkley N, Bouillon R, Ebeling PR, Lazaretti-Castro M, Marcocci C, Rizzoli R, Sempos CT, Bilezikian JP.Controversies in vitamin D: summary statement from an international conference. J Clin Endocrinol Metab. 2019;104(2):234–240. doi: 10.1210/jc.2018-01414.
4. Roth DE, Abrams SA, Aloia J, et al. Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in lowand middle-income countries. Ann N Y Acad Sci. 2018;1430(1):44-79. doi:10.1111/nyas.13968
5. LeFevre M.L., Force U.S. Screening for vitamin D deficiency in adults: U.S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 2015;162:133–140. doi: 10.7326/M14-2450.
6. Исупова А. А., Исупов Р.В. Детерминанты показателей сывороточного 25 (OH) D коренных жителей Кыргызстана. Здравоохранение Кыргызстана. – 2021. – № 4. – С. 34-39. – DOI 10.51350/zdravkg2021124334. [Isupova A. A., Isupov R.V. Determinanty pokazatelej syvorotochnogo 25 (OH) D korennyh zhitelej Kyrgyzstana. Zdravoohranenie Kyrgyzstana. – 2021. – №4. – S. 34-39. – DOI 10.51350/zdravkg2021124334.]
7. Siddiqee MH, Bhattacharjee B, Siddiqi UR, Rahman MM. High burden of hypovitaminosis D among the children and adolescents in South Asia: a systematic review and meta-analysis. J Health Popul Nutr. 2022;41(1):10. Published 2022 Mar 17.doi:10.1186/s41043-022-00287-w.
8. Jeyakumar A, Shinde V. A systematic review and meta-analysis of prevalence of vitamin D deficiency among adolescent girls in selected Indian states. Nutr Health. 2019;25(1):61–70. doi: 10.1177/0260106018805360.
9. Norman A. Vitamin D. In: Bowman B.A., Russel R.E., editors. Present knowledge of nutrition. 8th ed. ILSI Press; Washington, DC: 2001. [chapter 13]
10. Vanchinathan V., Lim H.W. A dermatologist’s perspective on vitamin D. Mayo Clin Proc. 2012;87:372–380
11. Haussler MR, Haussler CA, Jurutka PW, Thompson PD, Hsieh JC, Remus LS, Selznick SH, Whitfield GK. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997 Sep;154 Suppl:S57-73. PMID: 9379138
12. Haussler MR, et al. New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone. Bone. 1995;17:33S–38S.
13. Wang Y, Zhu J, DeLuca HF. Where is the vitamin D receptor? Arch Biochem Biophys. 2012;523(1):123–133.
doi: 10.1016/j.abb.2012.04.001
14. Holick MF, Schnoes HK, DeLuca HF. Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Natl Acad Sci U S A. 1971;68(4):803–804. doi: 10.1073/pnas.68.4.803.
15. Pike JW, Meyer MB, Lee SM, Onal M, Benkusky NA. The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights. J Clin Invest. 2017;127(4):1146-1154. doi:10.1172/JCI88887
16. Brenner M, Hearing VJ. The protective role of melanin against UV damage in human skin. Photochem Photobiol. 2008; 84(3):539-549. doi:10.1111/j.1751-1097.2007.00226.x
17. O'Sullivan F, Raftery T, van Weele M, van Geffen J, McNamara D, O'Morain C, et al. Sunshine is an important determinant of vitamin D status even among high-dose supplement users: secondary analysis of a randomized controlled trial in Crohn's disease patients. Photochem Photobiol. 2019;95(4):1060–1067. doi: 10.1111/php.13086.
18. McCullough PJ, McCullough WP, Lehrer D, Travers JB, Repas SJ. Oral and Topical Vitamin D, Sunshine, and UVB Photothera py Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-Hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications. Nutrients. 2021;13(5):1511. Published 2021 Apr 29. doi:10.3390/nu13051511
19. Webb AR, DeCosta BR, Holick MF. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. Journal of Clinical Endocrinology and Metabolism. 1989;68(5):882–887.
20. Brzeminski P, Fabisiak A, Slominski RM, Kim TK, Janjetovic Z, Podgorska E, Song Y, Saleem M, Reddy SB, Qayyum S, Song Y,Tuckey RC, Atigadda V, Jetten AM, Sicinski RR, Raman C, Slominski AT. Chemical synthesis, biological activities and action on nuclear receptors of 20S(OH)D3, 20S,25(OH)2D3, 20S,23S(OH)2D3 and 20S,23R(OH)2D3. Bioorg Chem. 2022 Apr;121:105660. doi: 10.1016/j.bioorg.2022.105660
21. Jiménez-sousa MÁ, Martínez I, Medrano LM. Vitamin D in human immunodeficiency virus infection: influence on immunity and disease. Front Immunol. (2018) 9:458. doi: 10.3389/fimmu.2018.00458 Bikle D.D. Vitamin D metabolism, mechanism of action, and clinical applications. Chem. Biol. 2014;21:319–329. doi: 10.1016/j.chembiol.2013.12.016
22. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA. Cloning of human 25-hydroxyvitamin D-1
alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1997 Dec;11(13):1961-70. doi: 10.1210/mend.11.13.0035.] Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinol. 2013;5(1):51-108. doi:10.4161/derm.24494
23. Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F,Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V. Effectiveness and safety of vitamin D in relation tobone health. Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. PMID: 18088161; PMCID: PMC4781354.
24. Minisola S, Colangelo L, Pepe J, Diacinti D, Cipriani C, Rao SD. Osteomalacia and Vitamin D Status: A Clinical Update 2020. JBMR Plus. 2020 Dec 21;5(1):e10447. doi: 10.1002/jbm4.10447
25. Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O. Vitamin D-related changes in physical performance: a systematic review. J Nutr Health Aging. 2009;13(10):893–898
26. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, et al. Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial. JAMA Intern Med. 2016;176(2):175–183
27. Mayo BC, Massel DH, Yacob A, Narain AS, Hijji FY, Jenkins NW, Parrish JM, Modi KD, Long WW, Hrynewycz NM,
Brundage TS, Singh K. A Review of Vitamin D in Spinal Surgery: Deficiency Screening, Treatment, and Outcomes. Int J
Spine Surg. 2020 Jun 30;14(3):447-454. doi: 10.14444/7059.]
28. Morris HA, Anderson PH. Autocrine and paracrine actions of vitamin d. Clin Biochem Rev. 2010 Nov;31(4):129-38.
29. Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. doi: 10.2215/CJN.01160308.
30. Mostafa WZ, Hegazy RA. Vitamin D and the skin: Focus on a complex relationship: A review. J Adv Res. 2015;6(6):793-804. doi:10.1016/j.jare.2014.01.011
31. Morris HA. Vitamin D activities for health outcomes. Ann Lab Med. 2014 May;34(3):181-6. doi: 10.3343/alm.2014.34.3.181
32. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–81.
33. Cuppari L, Garcia-Lopes MG. Hypovitaminosis D in chronic kidney disease patients: prevalence and treatment. J Ren Nutr.2009;19:38–43.
34. Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. doi: 10.2215/CJN.01160308
35. Medrano M., Carrillo-Cruz E., Montero I., Perez-Simon J.A. Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. Int. J. Mol. Sci. 2018;19:2663. doi: 10.3390/ijms19092663
36. Gruber-Bzura B.M.Vitamin D and Influenza-Prevention or Therapy? Int. J. Mol. Sci. 2018;19:2419. doi: 10.33 90/ijms 19082419
37. Carlberg C. Vitamin D Signaling in the Context of Innate Immunity: Focus on Human Monocytes. Front. Immunol. 2019;10:2211. doi: 10.3389/fimmu.2019.02211
38. Huang SJ, Wang XH, Liu ZD, et al. Vitamin D deficiency and the risk of tuberculosis: a meta-analysis. Drug Des Devel Ther. 2017;11:91–102. doi: 10.2147/DDDT.S79870
39. Jiménez-sousa MÁ, Martínez I, Medrano LM. Vitamin D in human immunodeficiency virus infection: influence on immunity and disease. Front Immunol. 2018; 9:458. doi: 10.3389/fimmu.2018.00458
40. Eyles DW. Vitamin D: Brain and Behavior. JBMR Plus. 2020 Oct 18;5(1):e10419. doi: 10.1002/jbm4.10419
41. Ali A, Cui X, Eyles D. Developmental vitamin D deficiency and autism: Putative pathogenic mechanisms. J Steroid Biochem Mol Biol. 2018 Jan;175:108-118. doi: 10.1016/j.jsbmb.2016.12.018.
42. Berridge MJ. Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia). Am J Physiol Cell Physiol. 2018 Feb 1;314(2):C135-C151. doi: 10.1152/ ajpcell. 00188.2017
43. Anjum I, Jaffery SS, Fayyaz M, Samoo Z, Anjum S. The Role of Vitamin D in Brain Health: A Mini Literature Review.
Cureus. 2018;10(7):e2960. Published 2018 Jul 10. doi:10.7759/cureus.2960
44. Yiu Y.F., Chan Y.H., Yiu K.H., Siu C.W., Li S.W., Wong L.Y., Lee S.W., Tam S., Wong E.W., Cheung B.M., et al. Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 2011;96:E830–E835. doi: 10.1210/jc.2010-2212
45. Latic N, Erben RG. Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure. Int J Mol Sci. 2020;21(18):6483. Published 2020 Sep 4. doi:10.3390/ijms21186483
46. Scragg R., Jackson R., Holdaway I.M., Lim T., Beaglehole R. Myocardial Infarction Is Inversely Associated With Plasma 25-Hydroxyvitamin D3 Levels: A Community-Based Study. Int. J. Epidemiol. 1990;19:559–563. doi: 10.1093/ije/19.3.559
47. Halcox JP, Deanfield JE. Childhood origins of endothelial dysfunction. Heart. 2005;91(10):1272-1274.
doi:10.1136/hrt.2005.061317
48. Gates PE, Strain WD, Shore AC. Human endothelial function and microvascular ageing. Exp Physiol. 2009 Mar;94(3):311-6. doi: 10.1113/expphysiol.2008.043349
49. Kim DH, Meza CA, Clarke H, Kim JS, Hickner RC. Vitamin D and Endothelial Function. Nutrients. 2020;12(2):575. Published 2020 Feb 22. doi:10.3390/nu12020575
50. Blair MJ, Jones JD, Woessner AE, Quinn KP. Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging. Adv Wound Care (New Rochelle). 2020;9(3):127-143. doi:10.1089/wound.2019.102151. D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222-12248. Published 2013 Jun 7. doi:10.3390/ijms140612222
52. Slominski A.T., Janjetovic Z., Kim T.K., Wasilewski P., Rosas S., Hanna S., Sayre R.M., Dowdy J.C., Li W., Tuckey R.C. Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J. Steroid Biochem. Mol. Biol. 2015;148:52–63. doi: 10.1016/j.jsbmb.2015.01.014
53. Slominski AT, Kim TK, Li W, Yi AK, Postlethwaite A, Tuckey RC. The role of CYP11A1 in the production of vitamin D
metabolites and their role in the regulation of epidermal functions. J Steroid Biochem Mol Biol. 2013
54. Dixon KM, Norman AW, Sequeira VB, Mohan R, Rybchyn MS, Reeve VE, Halliday GM, Mason RS. 1alpha,25(OH)(2)-vitamin D and a nongenomic vitamin D analogue inhibit ultraviolet radiation-induced skin carcinogenesis. Cancer Prev Res(Phila) 2011;4:1485–1494.
55. Grant W.B. The effect of solar UVB doses and vitamin D production, skin cancer action spectra, and smoking in explaining links between skin cancers and solid tumours. Eur. J. Cancer. 2008;44:12–15. doi: 10.1016/j.ejca. 2007. 09. 009
56. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76:1536–8. doi: 10.1172/JCI112134
57. Reichrath J. Unravelling of hidden secrets: The role of vitamin D in skin aging. Dermatoendocrinol. 2012;4(3):241-244.doi:10.4161/derm.21312
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59. Haussler MR, Haussler CA, Whitfield GK, Hsieh JC, Thompson PD, Barthel TK, et al. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging. J Steroid Biochem Mol Biol. 2010;121:88–97. doi: 10.1016/j.jsbmb.2010.03.019
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Для цитирования

Исупова А.А. , Исупов Р.В. О роли дефицита витамина D в развитии коморбидных состояний связанных с возрастом. Здравоохранение Кыргызстана 2022, № 1,с.123-129. 
https://dx.doi.org/10.51350/zdravkg20223118123
Английский
About authors

Isupova Alena Anatolyevna , Candidate of Medical Sciences, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Senior Lecturer of the Department of Dermatovenerology and Phthisiology, Bishkek, Kyrgyz Republic;
Isupov Roman Alekeslavovich, PhD student, B.N. Yeltsin Kyrgyz-Russian Slavonic University, Bishkek, Kyrgyz Republic
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References

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6. Isupova A. A., Isupov R.V. Determinanty pokazatelej syvorotochnogo 25 (OH) D korennyh zhitelej Kyrgyzstana. Zdravoohranenie Kyrgyzstana. – 2021. – №4. – S. 34-39. – DOI 10.51350/zdravkg2021124334.
7. Siddiqee MH, Bhattacharjee B, Siddiqi UR, Rahman MM. High burden of hypovitaminosis D among the children and adolescents in South Asia: a systematic review and meta-analysis. J Health Popul Nutr. 2022;41(1):10. Published 2022 Mar 17.doi:10.1186/s41043-022-00287-w.
8. Jeyakumar A, Shinde V. A systematic review and meta-analysis of prevalence of vitamin D deficiency among adolescent girls in selected Indian states. Nutr Health. 2019;25(1):61–70. doi: 10.1177/0260106018805360.
9. Norman A. Vitamin D. In: Bowman B.A., Russel R.E., editors. Present knowledge of nutrition. 8th ed. ILSI Press; Washington, DC: 2001. [chapter 13]
10. Vanchinathan V., Lim H.W. A dermatologist’s perspective on vitamin D. Mayo Clin Proc. 2012;87:372–380
11. Haussler MR, Haussler CA, Jurutka PW, Thompson PD, Hsieh JC, Remus LS, Selznick SH, Whitfield GK. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997 Sep;154 Suppl:S57-73. PMID: 9379138
12. Haussler MR, et al. New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone. Bone. 1995;17:33S–38S.
13. Wang Y, Zhu J, DeLuca HF. Where is the vitamin D receptor? Arch Biochem Biophys. 2012;523(1):123–133.
doi: 10.1016/j.abb.2012.04.001
14. Holick MF, Schnoes HK, DeLuca HF. Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Natl Acad Sci U S A. 1971;68(4):803–804. doi: 10.1073/pnas.68.4.803.
15. Pike JW, Meyer MB, Lee SM, Onal M, Benkusky NA. The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights. J Clin Invest. 2017;127(4):1146-1154. doi:10.1172/JCI88887
16. Brenner M, Hearing VJ. The protective role of melanin against UV damage in human skin. Photochem Photobiol. 2008; 84(3):539-549. doi:10.1111/j.1751-1097.2007.00226.x
17. O'Sullivan F, Raftery T, van Weele M, van Geffen J, McNamara D, O'Morain C, et al. Sunshine is an important determinant of vitamin D status even among high-dose supplement users: secondary analysis of a randomized controlled trial in Crohn's disease patients. Photochem Photobiol. 2019;95(4):1060–1067. doi: 10.1111/php.13086.
18. McCullough PJ, McCullough WP, Lehrer D, Travers JB, Repas SJ. Oral and Topical Vitamin D, Sunshine, and UVB Photothera py Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-Hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications. Nutrients. 2021;13(5):1511. Published 2021 Apr 29. doi:10.3390/nu13051511
19. Webb AR, DeCosta BR, Holick MF. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. Journal of Clinical Endocrinology and Metabolism. 1989;68(5):882–887.
20. Brzeminski P, Fabisiak A, Slominski RM, Kim TK, Janjetovic Z, Podgorska E, Song Y, Saleem M, Reddy SB, Qayyum S, Song Y,Tuckey RC, Atigadda V, Jetten AM, Sicinski RR, Raman C, Slominski AT. Chemical synthesis, biological activities and action on nuclear receptors of 20S(OH)D3, 20S,25(OH)2D3, 20S,23S(OH)2D3 and 20S,23R(OH)2D3. Bioorg Chem. 2022 Apr;121:105660. doi: 10.1016/j.bioorg.2022.105660
21. Jiménez-sousa MÁ, Martínez I, Medrano LM. Vitamin D in human immunodeficiency virus infection: influence on immunity and disease. Front Immunol. (2018) 9:458. doi: 10.3389/fimmu.2018.00458 Bikle D.D. Vitamin D metabolism, mechanism of action, and clinical applications. Chem. Biol. 2014;21:319–329. doi: 10.1016/j.chembiol.2013.12.016
22. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA. Cloning of human 25-hydroxyvitamin D-1
alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1997 Dec;11(13):1961-70. doi: 10.1210/mend.11.13.0035.] Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinol. 2013;5(1):51-108. doi:10.4161/derm.24494
23. Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F,Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V. Effectiveness and safety of vitamin D in relation tobone health. Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. PMID: 18088161; PMCID: PMC4781354.
24. Minisola S, Colangelo L, Pepe J, Diacinti D, Cipriani C, Rao SD. Osteomalacia and Vitamin D Status: A Clinical Update 2020. JBMR Plus. 2020 Dec 21;5(1):e10447. doi: 10.1002/jbm4.10447
25. Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O. Vitamin D-related changes in physical performance: a systematic review. J Nutr Health Aging. 2009;13(10):893–898
26. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, et al. Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial. JAMA Intern Med. 2016;176(2):175–183
27. Mayo BC, Massel DH, Yacob A, Narain AS, Hijji FY, Jenkins NW, Parrish JM, Modi KD, Long WW, Hrynewycz NM,
Brundage TS, Singh K. A Review of Vitamin D in Spinal Surgery: Deficiency Screening, Treatment, and Outcomes. Int J
Spine Surg. 2020 Jun 30;14(3):447-454. doi: 10.14444/7059.]
28. Morris HA, Anderson PH. Autocrine and paracrine actions of vitamin d. Clin Biochem Rev. 2010 Nov;31(4):129-38.
29. Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. doi: 10.2215/CJN.01160308.
30. Mostafa WZ, Hegazy RA. Vitamin D and the skin: Focus on a complex relationship: A review. J Adv Res. 2015;6(6):793-804. doi:10.1016/j.jare.2014.01.011
31. Morris HA. Vitamin D activities for health outcomes. Ann Lab Med. 2014 May;34(3):181-6. doi: 10.3343/alm.2014.34.3.181
32. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–81.
33. Cuppari L, Garcia-Lopes MG. Hypovitaminosis D in chronic kidney disease patients: prevalence and treatment. J Ren Nutr.2009;19:38–43.
34. Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. doi: 10.2215/CJN.01160308
35. Medrano M., Carrillo-Cruz E., Montero I., Perez-Simon J.A. Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. Int. J. Mol. Sci. 2018;19:2663. doi: 10.3390/ijms19092663
36. Gruber-Bzura B.M.Vitamin D and Influenza-Prevention or Therapy? Int. J. Mol. Sci. 2018;19:2419. doi: 10.33 90/ijms 19082419
37. Carlberg C. Vitamin D Signaling in the Context of Innate Immunity: Focus on Human Monocytes. Front. Immunol. 2019;10:2211. doi: 10.3389/fimmu.2019.02211
38. Huang SJ, Wang XH, Liu ZD, et al. Vitamin D deficiency and the risk of tuberculosis: a meta-analysis. Drug Des Devel Ther. 2017;11:91–102. doi: 10.2147/DDDT.S79870
39. Jiménez-sousa MÁ, Martínez I, Medrano LM. Vitamin D in human immunodeficiency virus infection: influence on immunity and disease. Front Immunol. 2018; 9:458. doi: 10.3389/fimmu.2018.00458
40. Eyles DW. Vitamin D: Brain and Behavior. JBMR Plus. 2020 Oct 18;5(1):e10419. doi: 10.1002/jbm4.10419
41. Ali A, Cui X, Eyles D. Developmental vitamin D deficiency and autism: Putative pathogenic mechanisms. J Steroid Biochem Mol Biol. 2018 Jan;175:108-118. doi: 10.1016/j.jsbmb.2016.12.018.
42. Berridge MJ. Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia). Am J Physiol Cell Physiol. 2018 Feb 1;314(2):C135-C151. doi: 10.1152/ ajpcell. 00188.2017
43. Anjum I, Jaffery SS, Fayyaz M, Samoo Z, Anjum S. The Role of Vitamin D in Brain Health: A Mini Literature Review.
Cureus. 2018;10(7):e2960. Published 2018 Jul 10. doi:10.7759/cureus.2960
44. Yiu Y.F., Chan Y.H., Yiu K.H., Siu C.W., Li S.W., Wong L.Y., Lee S.W., Tam S., Wong E.W., Cheung B.M., et al. Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 2011;96:E830–E835. doi: 10.1210/jc.2010-2212
45. Latic N, Erben RG. Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure. Int J Mol Sci. 2020;21(18):6483. Published 2020 Sep 4. doi:10.3390/ijms21186483
46. Scragg R., Jackson R., Holdaway I.M., Lim T., Beaglehole R. Myocardial Infarction Is Inversely Associated With Plasma 25-Hydroxyvitamin D3 Levels: A Community-Based Study. Int. J. Epidemiol. 1990;19:559–563. doi: 10.1093/ije/19.3.559
47. Halcox JP, Deanfield JE. Childhood origins of endothelial dysfunction. Heart. 2005;91(10):1272-1274.
doi:10.1136/hrt.2005.061317
48. Gates PE, Strain WD, Shore AC. Human endothelial function and microvascular ageing. Exp Physiol. 2009 Mar;94(3):311-6. doi: 10.1113/expphysiol.2008.043349
49. Kim DH, Meza CA, Clarke H, Kim JS, Hickner RC. Vitamin D and Endothelial Function. Nutrients. 2020;12(2):575. Published 2020 Feb 22. doi:10.3390/nu12020575
50. Blair MJ, Jones JD, Woessner AE, Quinn KP. Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging. Adv Wound Care (New Rochelle). 2020;9(3):127-143. doi:10.1089/wound.2019.102151. D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222-12248. Published 2013 Jun 7. doi:10.3390/ijms140612222
52. Slominski A.T., Janjetovic Z., Kim T.K., Wasilewski P., Rosas S., Hanna S., Sayre R.M., Dowdy J.C., Li W., Tuckey R.C. Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J. Steroid Biochem. Mol. Biol. 2015;148:52–63. doi: 10.1016/j.jsbmb.2015.01.014
53. Slominski AT, Kim TK, Li W, Yi AK, Postlethwaite A, Tuckey RC. The role of CYP11A1 in the production of vitamin D
metabolites and their role in the regulation of epidermal functions. J Steroid Biochem Mol Biol. 2013
54. Dixon KM, Norman AW, Sequeira VB, Mohan R, Rybchyn MS, Reeve VE, Halliday GM, Mason RS. 1alpha,25(OH)(2)-vitamin D and a nongenomic vitamin D analogue inhibit ultraviolet radiation-induced skin carcinogenesis. Cancer Prev Res(Phila) 2011;4:1485–1494.
55. Grant W.B. The effect of solar UVB doses and vitamin D production, skin cancer action spectra, and smoking in explaining links between skin cancers and solid tumours. Eur. J. Cancer. 2008;44:12–15. doi: 10.1016/j.ejca. 2007. 09. 009
56. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76:1536–8. doi: 10.1172/JCI112134
57. Reichrath J. Unravelling of hidden secrets: The role of vitamin D in skin aging. Dermatoendocrinol. 2012;4(3):241-244.doi:10.4161/derm.21312
58. Warwick, T., Schulz, M.H., Günther, S. et al. A hierarchical regulatory network analysis of the vitamin D induced transcrip tome reveals novel regulators and complete VDR dependency in monocytes. Sci Rep 11, 6518 (2021). https://doi.org/10.1038/s41598-021-86032-5
59. Haussler MR, Haussler CA, Whitfield GK, Hsieh JC, Thompson PD, Barthel TK, et al. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging. J Steroid Biochem Mol Biol. 2010;121:88–97. doi: 10.1016/j.jsbmb.2010.03.019
60. Grabowska W, Sikora E & Bielak-Zmijewska A (2017). Sirtuins, a promising target in slowing down the ageing process. Biogerontology 18, 447–476.
61. Gonzalo S, Kreienkamp R & Askjaer P (2017). Hutchinson-Gilford progeria syndrome: a premature aging disease caused by LMNA gene mutations. Ageing Res Rev 33, 18–29
62. Bocheva G, Slominski RM, Slominski AT. The Impact of Vitamin D on Skin Aging. Int J Mol Sci. 2021 Aug 23;22(16):9097.doi: 10.3390/ijms22169097
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Isupova A.A., Isupov R.V.On the role of vitamin D defiiency in the development of age-related comorbid conditions.Health care of Kyrgyzstan 2022, No.1, pp. 123-129. 
https://dx.doi.org/10.51350/zdravkg20223118123
Кыргызский
Авторлор жөнүндө

Исупова Алена Анатольевна, медицина илимдеринин кандидаты, Б.Н. Ельцин атындагы Кыргыз-Россия славиян университетинун тери-венерология жана фтизиатрия кафедрасынын ага окутуучусу, Бишкек, Кыргыз Республикасы;

Исупов Роман Вячеславович, Б.Н. Ельцин атындагы Кыргыз-Орус Славян университетинин аспиранты, Бишкек, Кыргыз Республикасы
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50. Blair MJ, Jones JD, Woessner AE, Quinn KP. Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging. Adv Wound Care (New Rochelle). 2020;9(3):127-143. doi:10.1089/wound.2019.102151. D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222-12248. Published 2013 Jun 7. doi:10.3390/ijms140612222
52. Slominski A.T., Janjetovic Z., Kim T.K., Wasilewski P., Rosas S., Hanna S., Sayre R.M., Dowdy J.C., Li W., Tuckey R.C. Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J. Steroid Biochem. Mol. Biol. 2015;148:52–63. doi: 10.1016/j.jsbmb.2015.01.014
53. Slominski AT, Kim TK, Li W, Yi AK, Postlethwaite A, Tuckey RC. The role of CYP11A1 in the production of vitamin D
metabolites and their role in the regulation of epidermal functions. J Steroid Biochem Mol Biol. 2013
54. Dixon KM, Norman AW, Sequeira VB, Mohan R, Rybchyn MS, Reeve VE, Halliday GM, Mason RS. 1alpha,25(OH)(2)-vitamin D and a nongenomic vitamin D analogue inhibit ultraviolet radiation-induced skin carcinogenesis. Cancer Prev Res(Phila) 2011;4:1485–1494.
55. Grant W.B. The effect of solar UVB doses and vitamin D production, skin cancer action spectra, and smoking in explaining links between skin cancers and solid tumours. Eur. J. Cancer. 2008;44:12–15. doi: 10.1016/j.ejca. 2007. 09. 009
56. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76:1536–8. doi: 10.1172/JCI112134
57. Reichrath J. Unravelling of hidden secrets: The role of vitamin D in skin aging. Dermatoendocrinol. 2012;4(3):241-244.doi:10.4161/derm.21312
58. Warwick, T., Schulz, M.H., Günther, S. et al. A hierarchical regulatory network analysis of the vitamin D induced transcrip tome reveals novel regulators and complete VDR dependency in monocytes. Sci Rep 11, 6518 (2021). https://doi.org/10.1038/s41598-021-86032-5
59. Haussler MR, Haussler CA, Whitfield GK, Hsieh JC, Thompson PD, Barthel TK, et al. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging. J Steroid Biochem Mol Biol. 2010;121:88–97. doi: 10.1016/j.jsbmb.2010.03.019
60. Grabowska W, Sikora E & Bielak-Zmijewska A (2017). Sirtuins, a promising target in slowing down the ageing process. Biogerontology 18, 447–476.
61. Gonzalo S, Kreienkamp R & Askjaer P (2017). Hutchinson-Gilford progeria syndrome: a premature aging disease caused by LMNA gene mutations. Ageing Res Rev 33, 18–29
62. Bocheva G, Slominski RM, Slominski AT. The Impact of Vitamin D on Skin Aging. Int J Mol Sci. 2021 Aug 23;22(16):9097.doi: 10.3390/ijms22169097
Цитата үчүн

Исупова А.А. , Исупов Р.В. Куракка байланышкан комоорбид абалдарынын өнүгүшүндө D витамининин жетишсиздигинин ролу жөнүндө. Кыргызстандын саламаттык сактоо 2022, № 1,
с.123-129. https://dx.doi.org/10.51350/zdravkg20223118123
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