Abstract
Abstract
Introduction. Infectious and inflammatory diseases of the maxillofacial area, such as radicular cyst jaws are
polymicrobial. Determination of the qualitative composition of the microbial flora and its genetic resistance to
antibacterial drugs in the area of the bone defect may be important in the choice of tactics for treating patients.
The aim of the study to determine the qualitative and quantitative composition of the microbial flora in patients
with relapses of radicular cysts with an assessment of the genetic resistance of pathogens to various groups of
antibacterial drugs. Material and methods. We observed 40 patients with recurrent radicular cysts jaws who underwent cystectomy
reoperation. In order to obtain data on the composition of the microbial flora in the area of the bone defect at the
time of the operation and in the postoperative period, additional molecular biological studies were carried out.
Results. According to the results of molecular biological research, anaerobic microflora of the oral cavity was
revealed, which included two main groups of periodontopathogenic and stabilizing microorganisms. The results
of PCR studies for the presence of genetic resistance of pathogens showed the following. In all samples (n = 40),
the resistance of microorganisms to β-lactams and tetracyclines was determined. Resistance to macrolides and
fluoroquinolones was detected in 50% (n = 20) of the samples. Metronidazole resistance has not been determined
in any sample.
Conclusion. The study made it possible to establish the presence of 3 or more periodontopathogenic pathogens
in the cavities of cysts at a concentration of 103 GE / ml and higher, which indicates the association of these microorganisms and their primary role in the occurrence of the disease
