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The informativeness of various types of pathological material samples in the laboratory diagnosis of tuberculosis in children

https://doi.org/10.51350/zdravkg202262758
The informativeness of various types of pathological material samples in the laboratory diagnosis of tuberculosis in children
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Abstract About the authors References

Abstract

Tuberculosis (TB) in children is characterized by the frequency of extrapulmonary localization of the process, the rarity and scarcity of bacterial excretion. WHO recommends that in order to improve the effectiveness of TB diagnosis, studies of any available diagnostic material should be carried out using all available laboratory methods. The purpose of this study was to study the informativeness of various types of diagnostic material samples for the detection of M. tuberculosis in children. Material and methods.A retrospective analysis of the results of microbiological studies on Mycobacterium tuberculosis in 1,676 children under the age of 15 for the period 2017-2021, performed in the Republican Reference Laboratory of the National Center of Phthisiology. Results. The most informative samples were biopsies/ resection material, the contents of fistulas, bronchial flushing water and cerebrospinal fluid. The sensitivity of rapid molecular methods of TB diagnostics (Xpert MTB/RIF, GenoTypeMDRTB plus) was higher compared to the results of culture (MGIT, LJ) and microscopy. Conclusion. The cumulative informativeness of various types of diagnostic material samples in the laboratory diagnosis of TB in children was 11.4%. As an initial diagnostic test, fast molecular methods are recommended to verify the diagnosis of TB and start its adequate treatment.

About the authors

Курманова Нурила Карыпбаевна, к.м.н., ассистент кафедры фтизиопульмонологии Кыргызского государственного института переподготовки и повышения квалификации им. С.Б. Даниярова, Бишкек,
Кыргызская Республика
Калмамбетова Гульмира Исмаиловна, к.м.н., зав. национальной референс лаборатории Национального Центра Фтизиатрии Министерства здравоохранения, Бишкек, Кыргызская Республика
Матаева Гулшан Камиловна, координатор по лабораторной диагностике ТБ, Республиканская Референс Лаборатория, Национального Центра Фтизиатрии Министерства здравоохранения, Бишкек,
Кыргызская Республика
Азыкова Айнура Бариевна, к.м.н., старший преподаватель кафедры дерматовенерологии и фтизиатрии Кыргызско - Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская
Республика

Kurmanova Nurila Karypbaevna, Ph.D., Assistant, Department of Phthisiopulmonology, Kyrgyz State Institute for Retraining and Advanced Training named after S.B. Daniyarov Bishkek, Kyrgyz Republic
Kalmambetova Gulmira Ismailovna, Ph.D., Head of the National Reference Laboratory of the National Center for Phthisiology of the Ministry of Health, Bishkek, Kyrgyz Republic
Mataeva Gulshan Kamilovna, Coordinator for TB Laboratory Diagnostics, Republican Reference Laboratory, National Center for Phthisiology of the Ministry of Health, Bishkek, Kyrgyz Republic
Azykova Ainura Barievna, Ph.D., Senior Lecturer, Department of Dermatovenerology and Phthisiology, B.N. Yeltsin Russian Slavic University, Bishkek, Kyrgyz Republic

Курманова Нурила Карыпбаевна, к.м.и., С. Б. Данияров атындагы Кыргыз мамлекеттик кайра даярдоо жана квалификациясын жогорулатуу институтунун фтизиопульмонология кафедрасынын ассистенти , Бишкек, Кыргыз Республикасы

Калмамбетова Гульмира Исмаиловна, к.м. и., зав. саламаттык сактоо министрлигинин Улуттук фтизиатрия борборунун лабораториясынын улуттук референси, Бишкек, Кыргыз Республикасы

Матаева Гулшан Камиловна, кургак учукту лабораториялык диагностикалоо боюнча координатор, республикалык Референс лабораториясы, Саламаттык сактоо министрлигинин Улуттук фтизиатрия борбору, Бишкек, Кыргыз Республикасы

Азыкова Айнура Бариевна, к.м. и., Б. Н. Ельцин атындагы Кыргыз - Россия Славян университетинин дерматовенерология жана фтизиатрия кафедрасынын ага окутуучусу , Бишкек, Кыргыз Республикасы

References

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2. WHO operational handbook on tuberculosis. Module 5: management of tuberculosis in children and adolescents (electronic version).WHO; 2022. https://apps.who.int/iris/rest/bitstreams/1414333/retrieve.[QUIS enchiridion operationis de tuberculosis.OMNIBUSV: De administratione tuberculosis in pueris et adolescentibus (versio electronica). OMS; 2022. https://apps.who. int/iris/rest/bitstreams/1414333/retrieve.]
3. Management of children with drug-resistant TB: a practical guide. Boston, USA, Sentinel Project to Combat the Spread of Drug-Resistant TB in Children; November, 2018, 4th edition.http://ftiziatr.org.ua/ftiziatrorgua/docsis/santel-rukovodstvo-rus.pdf [Procuratio puerorum cum medicamento repugnant TB: dux practicus. Boston, USA, Vigil Project ad pugnandum ad propagationemmedi camentorum resistentium TB in Pueris; November, 2018, 4th edition.]
4. Sandgren A, Hollo V, Quinten C, Manissero D. Childhood tuberculosis in the European Union/European Economic Area, 2000 to 2009. Euro Surveill. 2011;16(12): pii=19825. https://www.eurosurveillance.org/images/dynamic/ EE/ V16N12/art19825.pdf.[Sandgren A, Hollo V, Quinten C, Manissero D. Puerilis tuberculosis in Unione Europaea / Area Oeconomica Europaea, MM ad 2009. Euro Surveill. 2011; 16 (12): pii=19825. https://www.eurosurveillance.org/images/dynamic/EE/V16N12/art19825.pdf.]
5. Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Childhood multidrug-resistant tuberculosis in the European Union and European Economic Area:an analysis of tuberculosis surveillance data from 2007 to 2015.Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/. [Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Puerilia multidrug-repugnantia tuberculosis in Unione Europaea et Area Oeconomica Europaea: analysis custodiae tuberculosis data a 2007 ad 2015. Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/.]
6. WHO operational handbook on tuberculosis. Module 3: diagnosis - rapid diagnostics for tuberculosis detention, 2021.
https://apps.who.int/iris/rest/ bitstreams/1354706/retrieve [QUIS de tuberculosis enchiridion perficiendis. Module 3: diagnosis -celeri diagnostica ad tuberculosis detentionem, 2021. https://apps.who.int/iris/rest/bitstreams/1354706/ retrieve]
7. WHO consolidated guidelines on tuberculosis. Module 5: management of tuberculosis in children and adolescents. WHO; 2022. https:// apps. who. int/ iris/rest/ bit streams/1414329/retrieve [QUAE normas tuberculosis contexuerunt. OMNIBUS V: De administratione tuberculosis in pueris et adolescentibus. OMS; 2022. https://apps. OMS. int/iris/requie/bit riui/1414329/retrieve]
8. Cordova J, Shiloh R, Gilman RH, et al. Evaluation of molecular tools for detection and drug susceptibility testing of Mycobacterium tuberculosis in stool specimens from patients with pulmonary tuberculosis. J Clin Microbiol 2010; 48: 1820–1826. http://dx. doi.org/10.1128/JCM.01161-09 [Cordubae J, Silo R, Gilman RH, et al. Aestimatio instrumentorum hypotheticorum pro deprehensioneet medicamento susceptibilitate probationis Mycobacterii tuberculosis in speciminibus aegri ab aegris cum tuberculosis pulmonis. J Clin Microbiol 2010; 48: 1820-1826. http://dx.doi.org/10.1128/JCM.01161-09]
9. Walters E, van der Zalm MM, Palmer M, et al.Xpert MTB/RIF on stool is useful for the rapid diagnosis of tuberculosis in young children with severe pulmonary disease. Pediatr Infect Dis J 2017; 36: 837–843. https: //pubmed. ncbi.nlm. nih. gov/ 28151842/[Walters E, van der Zalm MM, Palmer M, et al Xpert MTB/RIF in alvus utilis est celeri diagnosi tuberculosis infantum cum gravi morbo pulmonali. Pediatr Infect Dis J 2017; 36: 837-843. https: // pubmed. ncbi.nlm. nih. gov/ 28151842/]
10. Marcy O, Ung V, Goyet S, et al. Performance of Xpert MTB/RIF and alternative specimen collection methods for the diagnosis of tuberculosis in HIV-infected children. Clin Infect Dis 2016; 62: 1161–1168.CrossRefPubMedGoogle Scholar. https://pubmed.ncbi.nlm.nih.gov/26908804/[Marcy O, Ung V, Goyet S, et al. Effectus Xpert MTB/RIF et alternative methodi speciminis collectionis diagnosis tuberculosis in pueris HIV-infectis. Clin Infect Dis 2016; 62: 1161–1168. CrossRefPubMedGoogle Scholar. https://pubmed. ncbi.nlm.nih.gov/26908804/]

1. Multidrug-resistant tuberculosis in children and adolescents in the WHO European Region. Expert opinion. WHO; 2020. https://apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- eng.pdf [Multidrug-repugnans tuberculosis puerorum et adulescentium in QUI Europae Regio est. doctissimi opinionis. OMS; 2020. https: //apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- lat.pdf]
2. WHO operational handbook on tuberculosis. Module 5: management of tuberculosis in children and adolescents (electronic version).WHO; 2022.https://apps.who.int/iris/rest/bitstreams/1414333/retrieve.[QUIS enchiridion operationis de tuberculosis.OMNIBUSV: De administratione tuberculosis in pueris et adolescentibus (versio electronica). OMS; 2022. https://apps.who. int/iris/rest/bitstreams/1414333/retrieve.]
3. Management of children with drug-resistant TB: a practical guide. Boston, USA, Sentinel Project to Combat the Spread of Drug-Resistant TB in Children; November, 2018, 4th edition.http://ftiziatr.org.ua/ftiziatrorgua/docsis/santel-rukovodstvo-rus.pdf [Procuratio puerorum cum medicamento repugnant TB: dux practicus. Boston, USA, Vigil Project ad pugnandum ad propagationemmedi camentorum resistentium TB in Pueris; November, 2018, 4th edition.]
4. Sandgren A, Hollo V, Quinten C, Manissero D. Childhood tuberculosis in the European Union/European Economic Area, 2000 to 2009. Euro Surveill. 2011;16(12): pii=19825. https://www.eurosurveillance.org/images/dynamic/ EE/ V16N12/art19825.pdf.[Sandgren A, Hollo V, Quinten C, Manissero D. Puerilis tuberculosis in Unione Europaea / Area Oeconomica Europaea, MM ad 2009. Euro Surveill. 2011; 16 (12): pii=19825. https://www.eurosurveillance.org/images/dynamic/EE/V16N12/art19825.pdf.]
5. Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Childhood multidrug-resistant tuberculosis in the European Union and European Economic Area:an analysis of tuberculosis surveillance data from 2007 to 2015.Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/. [Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Puerilia multidrug-repugnantia tuberculosis in Unione Europaea et Area Oeconomica Europaea: analysis custodiae tuberculosis data a 2007 ad 2015. Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/.]
6. WHO operational handbook on tuberculosis. Module 3: diagnosis - rapid diagnostics for tuberculosis detention, 2021.
https://apps.who.int/iris/rest/ bitstreams/1354706/retrieve [QUIS de tuberculosis enchiridion perficiendis. Module 3: diagnosis -celeri diagnostica ad tuberculosis detentionem, 2021. https://apps.who.int/iris/rest/bitstreams/1354706/ retrieve]
7. WHO consolidated guidelines on tuberculosis. Module 5: management of tuberculosis in children and adolescents. WHO; 2022. https:// apps. who. int/ iris/rest/ bit streams/1414329/retrieve [QUAE normas tuberculosis contexuerunt. OMNIBUS V: De administratione tuberculosis in pueris et adolescentibus. OMS; 2022. https://apps. OMS. int/iris/requie/bit riui/1414329/retrieve]
8. Cordova J, Shiloh R, Gilman RH, et al. Evaluation of molecular tools for detection and drug susceptibility testing of Mycobacterium tuberculosis in stool specimens from patients with pulmonary tuberculosis. J Clin Microbiol 2010; 48: 1820–1826. http://dx. doi.org/10.1128/JCM.01161-09 [Cordubae J, Silo R, Gilman RH, et al. Aestimatio instrumentorum hypotheticorum pro deprehensioneet medicamento susceptibilitate probationis Mycobacterii tuberculosis in speciminibus aegri ab aegris cum tuberculosis pulmonis. J Clin Microbiol 2010; 48: 1820-1826. http://dx.doi.org/10.1128/JCM.01161-09]
9. Walters E, van der Zalm MM, Palmer M, et al.Xpert MTB/RIF on stool is useful for the rapid diagnosis of tuberculosis in young children with severe pulmonary disease. Pediatr Infect Dis J 2017; 36: 837–843. https: //pubmed. ncbi.nlm. nih. gov/ 28151842/[Walters E, van der Zalm MM, Palmer M, et al Xpert MTB/RIF in alvus utilis est celeri diagnosi tuberculosis infantum cum gravi morbo pulmonali. Pediatr Infect Dis J 2017; 36: 837-843. https: // pubmed. ncbi.nlm. nih. gov/ 28151842/]
10. Marcy O, Ung V, Goyet S, et al. Performance of Xpert MTB/RIF and alternative specimen collection methods for the diagnosis of tuberculosis in HIV-infected children. Clin Infect Dis 2016; 62: 1161–1168.CrossRefPubMedGoogle Scholar. https://pubmed.ncbi.nlm.nih.gov/26908804/[Marcy O, Ung V, Goyet S, et al. Effectus Xpert MTB/RIF et alternative methodi speciminis collectionis diagnosis tuberculosis in pueris HIV-infectis. Clin Infect Dis 2016; 62: 1161–1168. CrossRefPubMedGoogle Scholar. https://pubmed. ncbi.nlm.nih.gov/26908804/]

1. Multidrug-resistant tuberculosis in children and adolescents in the WHO European Region. Expert opinion. WHO; 2020. https://apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- eng.pdf [Multidrug-repugnans tuberculosis puerorum et adulescentium in QUI Europae Regio est. doctissimi opinionis. OMS; 2020. https: //apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- lat.pdf]
2. WHO operational handbook on tuberculosis. Module 5: management of tuberculosis in children and adolescents (electronic version).WHO; 2022. https://apps.who.int/iris/rest/bitstreams/1414333/retrieve.[QUIS enchiridion operationis de tuberculosis.OMNIBUSV: De administratione tuberculosis in pueris et adolescentibus (versio electronica). OMS; 2022. https://apps.who. int/iris/rest/bitstreams/1414333/retrieve.]
3. Management of children with drug-resistant TB: a practical guide. Boston, USA, Sentinel Project to Combat the Spread of Drug-Resistant TB in Children; November, 2018, 4th edition.http://ftiziatr.org.ua/ftiziatrorgua/docsis/santel-rukovodstvo-rus.pdf [Procuratio puerorum cum medicamento repugnant TB: dux practicus. Boston, USA, Vigil Project ad pugnandum ad propagationemmedi camentorum resistentium TB in Pueris; November, 2018, 4th edition.]
4. Sandgren A, Hollo V, Quinten C, Manissero D. Childhood tuberculosis in the European Union/European Economic Area, 2000 to 2009. Euro Surveill. 2011;16(12): pii=19825. https://www.eurosurveillance.org/images/dynamic/ EE/ V16N12/art19825.pdf.[Sandgren A, Hollo V, Quinten C, Manissero D. Puerilis tuberculosis in Unione Europaea / Area Oeconomica Europaea, MM ad 2009. Euro Surveill. 2011; 16 (12): pii=19825. https://www.eurosurveillance.org/images/dynamic/EE/V16N12/art19825.pdf.]
5. Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Childhood multidrug-resistant tuberculosis in the European Union and European Economic Area:an analysis of tuberculosis surveillance data from 2007 to 2015.Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/. [Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Puerilia multidrug-repugnantia tuberculosis in Unione Europaea et Area Oeconomica Europaea: analysis custodiae tuberculosis data a 2007 ad 2015. Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/.]
6. WHO operational handbook on tuberculosis. Module 3: diagnosis - rapid diagnostics for tuberculosis detention, 2021.
https://apps.who.int/iris/rest/ bitstreams/1354706/retrieve [QUIS de tuberculosis enchiridion perficiendis. Module 3: diagnosis -celeri diagnostica ad tuberculosis detentionem, 2021. https://apps.who.int/iris/rest/bitstreams/1354706/ retrieve]
7. WHO consolidated guidelines on tuberculosis. Module 5: management of tuberculosis in children and adolescents. WHO; 2022. https:// apps. who. int/ iris/rest/ bit streams/1414329/retrieve [QUAE normas tuberculosis contexuerunt. OMNIBUS V: De administratione tuberculosis in pueris et adolescentibus. OMS; 2022. https://apps. OMS. int/iris/requie/bit riui/1414329/retrieve]
8. Cordova J, Shiloh R, Gilman RH, et al. Evaluation of molecular tools for detection and drug susceptibility testing of Mycobacterium tuberculosis in stool specimens from patients with pulmonary tuberculosis. J Clin Microbiol 2010; 48: 1820–1826. http://dx. doi.org/10.1128/JCM.01161-09 [Cordubae J, Silo R, Gilman RH, et al. Aestimatio instrumentorum hypotheticorum pro deprehensioneet medicamento susceptibilitate probationis Mycobacterii tuberculosis in speciminibus aegri ab aegris cum tuberculosis pulmonis. J Clin Microbiol 2010; 48: 1820-1826. http://dx.doi.org/10.1128/JCM.01161-09]
9. Walters E, van der Zalm MM, Palmer M, et al.Xpert MTB/RIF on stool is useful for the rapid diagnosis of tuberculosis in young children with severe pulmonary disease. Pediatr Infect Dis J 2017; 36: 837–843. https: //pubmed. ncbi.nlm. nih. gov/ 28151842/[Walters E, van der Zalm MM, Palmer M, et al Xpert MTB/RIF in alvus utilis est celeri diagnosi tuberculosis infantum cum gravi morbo pulmonali. Pediatr Infect Dis J 2017; 36: 837-843. https: // pubmed. ncbi.nlm. nih. gov/ 28151842/]
10. Marcy O, Ung V, Goyet S, et al. Performance of Xpert MTB/RIF and alternative specimen collection methods for the diagnosis of tuberculosis in HIV-infected children. Clin Infect Dis 2016; 62: 1161–1168.CrossRefPubMedGoogle Scholar. https://pubmed.ncbi.nlm.nih.gov/26908804/[Marcy O, Ung V, Goyet S, et al. Effectus Xpert MTB/RIF et alternative methodi speciminis collectionis diagnosis tuberculosis in pueris HIV-infectis. Clin Infect Dis 2016; 62: 1161–1168. CrossRefPubMedGoogle Scholar. https://pubmed. ncbi.nlm.nih.gov/26908804/]

Keywords
Xpert MTB/RIF Ultra , GenoTypeMDRTB plus , M. tuberculosis , Diagnosis , children , samples , pathological material , informative
Для цитирования

Курманова Н.К., Калманбетова Г.И., Матаева Г.К., Азыкова А.Б. Информативность различных образцов патологического материала при лабораторной диагностике туберкулеза у детей. Здравоохранение Кыргызстана 2022, № 2,с. 58-64. https://dx.doi.org/10.51350/zdravkg202262758
For citation

Kurmanova N. K., Kalmanbetova G.I., Mataeva G. K., Azykova A.B. The informativeness of various types of pathological material samples in the laboratory diagnosis of tuberculosis in children.Health care of Kyrgyzstan 2022, No.2, pp. 58-64.

https://dx.doi.org/10.51350/zdravkg202262758
Цитата үчүн

Курманова Н.К., Калманбетова Г.И., Матаева Г.К., Азыкова А.Б. Балдардын кургак учугун оорусундагы патологиялык материалдын ар түрдүү үлгөлөрүнүн лабораториалык түрдө диагностикалоонун
маалыматуулугу. Кыргызстандын саламаттык сактоо 2022, no 2, б. 58-64.  https://dx.doi.org/10.51350/zdravkg202262758
Authors Kurmanova N. K., Kalmanbetova G.I., Mataeva G.K., Azykova A.B.
Link doi.org https://doi.org/10.51350/zdravkg202262758
Pages 58-64
Keywords Xpert MTB/RIF Ultra, GenoTypeMDRTB plus, M. tuberculosis, Diagnosis, children, samples, pathological material, informative
Russian
Об авторах

Курманова Нурила Карыпбаевна, к.м.н., ассистент кафедры фтизиопульмонологии Кыргызского государственного института переподготовки и повышения квалификации им. С.Б. Даниярова, Бишкек,
Кыргызская Республика
Калмамбетова Гульмира Исмаиловна, к.м.н., зав. национальной референс лаборатории Национального Центра Фтизиатрии Министерства здравоохранения, Бишкек, Кыргызская Республика
Матаева Гулшан Камиловна, координатор по лабораторной диагностике ТБ, Республиканская Референс Лаборатория, Национального Центра Фтизиатрии Министерства здравоохранения, Бишкек,
Кыргызская Республика
Азыкова Айнура Бариевна, к.м.н., старший преподаватель кафедры дерматовенерологии и фтизиатрии Кыргызско - Российского Славянского университета им. Б.Н. Ельцина, Бишкек, Кыргызская
Республика
Полный текст

PDF (RUS)
Список литературы

1. Multidrug-resistant tuberculosis in children and adolescents in the WHO European Region. Expert opinion. WHO; 2020. https://apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- eng.pdf [Multidrug-repugnans tuberculosis puerorum et adulescentium in QUI Europae Regio est. doctissimi opinionis. OMS; 2020. https: //apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- lat.pdf]
2. WHO operational handbook on tuberculosis. Module 5: management of tuberculosis in children and adolescents (electronic version).WHO; 2022. https://apps.who.int/iris/rest/bitstreams/1414333/retrieve.[QUIS enchiridion operationis de tuberculosis.OMNIBUSV: De administratione tuberculosis in pueris et adolescentibus (versio electronica). OMS; 2022. https://apps.who. int/iris/rest/bitstreams/1414333/retrieve.]
3. Management of children with drug-resistant TB: a practical guide. Boston, USA, Sentinel Project to Combat the Spread of Drug-Resistant TB in Children; November, 2018, 4th edition.http://ftiziatr.org.ua/ftiziatrorgua/docsis/santel-rukovodstvo-rus.pdf [Procuratio puerorum cum medicamento repugnant TB: dux practicus. Boston, USA, Vigil Project ad pugnandum ad propagationemmedi camentorum resistentium TB in Pueris; November, 2018, 4th edition.]
4. Sandgren A, Hollo V, Quinten C, Manissero D. Childhood tuberculosis in the European Union/European Economic Area, 2000 to 2009. Euro Surveill. 2011;16(12): pii=19825. https://www.eurosurveillance.org/images/dynamic/ EE/ V16N12/art19825.pdf.[Sandgren A, Hollo V, Quinten C, Manissero D. Puerilis tuberculosis in Unione Europaea / Area Oeconomica Europaea, MM ad 2009. Euro Surveill. 2011; 16 (12): pii=19825. https://www.eurosurveillance.org/images/dynamic/EE/V16N12/art19825.pdf.]
5. Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Childhood multidrug-resistant tuberculosis in the European Union and European Economic Area:an analysis of tuberculosis surveillance data from 2007 to 2015.Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/. [Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Puerilia multidrug-repugnantia tuberculosis in Unione Europaea et Area Oeconomica Europaea: analysis custodiae tuberculosis data a 2007 ad 2015. Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/.]
6. WHO operational handbook on tuberculosis. Module 3: diagnosis - rapid diagnostics for tuberculosis detention, 2021.
https://apps.who.int/iris/rest/ bitstreams/1354706/retrieve [QUIS de tuberculosis enchiridion perficiendis. Module 3: diagnosis -celeri diagnostica ad tuberculosis detentionem, 2021. https://apps.who.int/iris/rest/bitstreams/1354706/ retrieve]
7. WHO consolidated guidelines on tuberculosis. Module 5: management of tuberculosis in children and adolescents. WHO; 2022. https:// apps. who. int/ iris/rest/ bit streams/1414329/retrieve [QUAE normas tuberculosis contexuerunt. OMNIBUS V: De administratione tuberculosis in pueris et adolescentibus. OMS; 2022. https://apps. OMS. int/iris/requie/bit riui/1414329/retrieve]
8. Cordova J, Shiloh R, Gilman RH, et al. Evaluation of molecular tools for detection and drug susceptibility testing of Mycobacterium tuberculosis in stool specimens from patients with pulmonary tuberculosis. J Clin Microbiol 2010; 48: 1820–1826. http://dx. doi.org/10.1128/JCM.01161-09 [Cordubae J, Silo R, Gilman RH, et al. Aestimatio instrumentorum hypotheticorum pro deprehensioneet medicamento susceptibilitate probationis Mycobacterii tuberculosis in speciminibus aegri ab aegris cum tuberculosis pulmonis. J Clin Microbiol 2010; 48: 1820-1826. http://dx.doi.org/10.1128/JCM.01161-09]
9. Walters E, van der Zalm MM, Palmer M, et al.Xpert MTB/RIF on stool is useful for the rapid diagnosis of tuberculosis in young children with severe pulmonary disease. Pediatr Infect Dis J 2017; 36: 837–843. https: //pubmed. ncbi.nlm. nih. gov/ 28151842/[Walters E, van der Zalm MM, Palmer M, et al Xpert MTB/RIF in alvus utilis est celeri diagnosi tuberculosis infantum cum gravi morbo pulmonali. Pediatr Infect Dis J 2017; 36: 837-843. https: // pubmed. ncbi.nlm. nih. gov/ 28151842/]
10. Marcy O, Ung V, Goyet S, et al. Performance of Xpert MTB/RIF and alternative specimen collection methods for the diagnosis of tuberculosis in HIV-infected children. Clin Infect Dis 2016; 62: 1161–1168.CrossRefPubMedGoogle Scholar. https://pubmed.ncbi.nlm.nih.gov/26908804/[Marcy O, Ung V, Goyet S, et al. Effectus Xpert MTB/RIF et alternative methodi speciminis collectionis diagnosis tuberculosis in pueris HIV-infectis. Clin Infect Dis 2016; 62: 1161–1168. CrossRefPubMedGoogle Scholar. https://pubmed. ncbi.nlm.nih.gov/26908804/]
Для цитирования

Курманова Н.К., Калманбетова Г.И., Матаева Г.К., Азыкова А.Б. Информативность различных образцов патологического материала при лабораторной диагностике туберкулеза у детей. Здравоохранение Кыргызстана 2022, № 2,с. 58-64. https://dx.doi.org/10.51350/zdravkg202262758
English
About authors

Kurmanova Nurila Karypbaevna, Ph.D., Assistant, Department of Phthisiopulmonology, Kyrgyz State Institute for Retraining and Advanced Training named after S.B. Daniyarov Bishkek, Kyrgyz Republic
Kalmambetova Gulmira Ismailovna, Ph.D., Head of the National Reference Laboratory of the National Center for Phthisiology of the Ministry of Health, Bishkek, Kyrgyz Republic
Mataeva Gulshan Kamilovna, Coordinator for TB Laboratory Diagnostics, Republican Reference Laboratory, National Center for Phthisiology of the Ministry of Health, Bishkek, Kyrgyz Republic
Azykova Ainura Barievna, Ph.D., Senior Lecturer, Department of Dermatovenerology and Phthisiology, B.N. Yeltsin Russian Slavic University, Bishkek, Kyrgyz Republic
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References

1. Multidrug-resistant tuberculosis in children and adolescents in the WHO European Region. Expert opinion. WHO; 2020. https://apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- eng.pdf [Multidrug-repugnans tuberculosis puerorum et adulescentium in QUI Europae Regio est. doctissimi opinionis. OMS; 2020. https: //apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- lat.pdf]
2. WHO operational handbook on tuberculosis. Module 5: management of tuberculosis in children and adolescents (electronic version).WHO; 2022.https://apps.who.int/iris/rest/bitstreams/1414333/retrieve.[QUIS enchiridion operationis de tuberculosis.OMNIBUSV: De administratione tuberculosis in pueris et adolescentibus (versio electronica). OMS; 2022. https://apps.who. int/iris/rest/bitstreams/1414333/retrieve.]
3. Management of children with drug-resistant TB: a practical guide. Boston, USA, Sentinel Project to Combat the Spread of Drug-Resistant TB in Children; November, 2018, 4th edition.http://ftiziatr.org.ua/ftiziatrorgua/docsis/santel-rukovodstvo-rus.pdf [Procuratio puerorum cum medicamento repugnant TB: dux practicus. Boston, USA, Vigil Project ad pugnandum ad propagationemmedi camentorum resistentium TB in Pueris; November, 2018, 4th edition.]
4. Sandgren A, Hollo V, Quinten C, Manissero D. Childhood tuberculosis in the European Union/European Economic Area, 2000 to 2009. Euro Surveill. 2011;16(12): pii=19825. https://www.eurosurveillance.org/images/dynamic/ EE/ V16N12/art19825.pdf.[Sandgren A, Hollo V, Quinten C, Manissero D. Puerilis tuberculosis in Unione Europaea / Area Oeconomica Europaea, MM ad 2009. Euro Surveill. 2011; 16 (12): pii=19825. https://www.eurosurveillance.org/images/dynamic/EE/V16N12/art19825.pdf.]
5. Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Childhood multidrug-resistant tuberculosis in the European Union and European Economic Area:an analysis of tuberculosis surveillance data from 2007 to 2015.Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/. [Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Puerilia multidrug-repugnantia tuberculosis in Unione Europaea et Area Oeconomica Europaea: analysis custodiae tuberculosis data a 2007 ad 2015. Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/.]
6. WHO operational handbook on tuberculosis. Module 3: diagnosis - rapid diagnostics for tuberculosis detention, 2021.
https://apps.who.int/iris/rest/ bitstreams/1354706/retrieve [QUIS de tuberculosis enchiridion perficiendis. Module 3: diagnosis -celeri diagnostica ad tuberculosis detentionem, 2021. https://apps.who.int/iris/rest/bitstreams/1354706/ retrieve]
7. WHO consolidated guidelines on tuberculosis. Module 5: management of tuberculosis in children and adolescents. WHO; 2022. https:// apps. who. int/ iris/rest/ bit streams/1414329/retrieve [QUAE normas tuberculosis contexuerunt. OMNIBUS V: De administratione tuberculosis in pueris et adolescentibus. OMS; 2022. https://apps. OMS. int/iris/requie/bit riui/1414329/retrieve]
8. Cordova J, Shiloh R, Gilman RH, et al. Evaluation of molecular tools for detection and drug susceptibility testing of Mycobacterium tuberculosis in stool specimens from patients with pulmonary tuberculosis. J Clin Microbiol 2010; 48: 1820–1826. http://dx. doi.org/10.1128/JCM.01161-09 [Cordubae J, Silo R, Gilman RH, et al. Aestimatio instrumentorum hypotheticorum pro deprehensioneet medicamento susceptibilitate probationis Mycobacterii tuberculosis in speciminibus aegri ab aegris cum tuberculosis pulmonis. J Clin Microbiol 2010; 48: 1820-1826. http://dx.doi.org/10.1128/JCM.01161-09]
9. Walters E, van der Zalm MM, Palmer M, et al.Xpert MTB/RIF on stool is useful for the rapid diagnosis of tuberculosis in young children with severe pulmonary disease. Pediatr Infect Dis J 2017; 36: 837–843. https: //pubmed. ncbi.nlm. nih. gov/ 28151842/[Walters E, van der Zalm MM, Palmer M, et al Xpert MTB/RIF in alvus utilis est celeri diagnosi tuberculosis infantum cum gravi morbo pulmonali. Pediatr Infect Dis J 2017; 36: 837-843. https: // pubmed. ncbi.nlm. nih. gov/ 28151842/]
10. Marcy O, Ung V, Goyet S, et al. Performance of Xpert MTB/RIF and alternative specimen collection methods for the diagnosis of tuberculosis in HIV-infected children. Clin Infect Dis 2016; 62: 1161–1168.CrossRefPubMedGoogle Scholar. https://pubmed.ncbi.nlm.nih.gov/26908804/[Marcy O, Ung V, Goyet S, et al. Effectus Xpert MTB/RIF et alternative methodi speciminis collectionis diagnosis tuberculosis in pueris HIV-infectis. Clin Infect Dis 2016; 62: 1161–1168. CrossRefPubMedGoogle Scholar. https://pubmed. ncbi.nlm.nih.gov/26908804/]
For citation

Kurmanova N. K., Kalmanbetova G.I., Mataeva G. K., Azykova A.B. The informativeness of various types of pathological material samples in the laboratory diagnosis of tuberculosis in children.Health care of Kyrgyzstan 2022, No.2, pp. 58-64.

https://dx.doi.org/10.51350/zdravkg202262758
Kyrgyz
Авторлор жөнүндө

Курманова Нурила Карыпбаевна, к.м.и., С. Б. Данияров атындагы Кыргыз мамлекеттик кайра даярдоо жана квалификациясын жогорулатуу институтунун фтизиопульмонология кафедрасынын ассистенти , Бишкек, Кыргыз Республикасы

Калмамбетова Гульмира Исмаиловна, к.м. и., зав. саламаттык сактоо министрлигинин Улуттук фтизиатрия борборунун лабораториясынын улуттук референси, Бишкек, Кыргыз Республикасы

Матаева Гулшан Камиловна, кургак учукту лабораториялык диагностикалоо боюнча координатор, республикалык Референс лабораториясы, Саламаттык сактоо министрлигинин Улуттук фтизиатрия борбору, Бишкек, Кыргыз Республикасы

Азыкова Айнура Бариевна, к.м. и., Б. Н. Ельцин атындагы Кыргыз - Россия Славян университетинин дерматовенерология жана фтизиатрия кафедрасынын ага окутуучусу , Бишкек, Кыргыз Республикасы
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Шилтемелер

1. Multidrug-resistant tuberculosis in children and adolescents in the WHO European Region. Expert opinion. WHO; 2020. https://apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- eng.pdf [Multidrug-repugnans tuberculosis puerorum et adulescentium in QUI Europae Regio est. doctissimi opinionis. OMS; 2020. https: //apps.who. int/ iris/ bitstream/handle/10665/329395/9789289054447- lat.pdf]
2. WHO operational handbook on tuberculosis. Module 5: management of tuberculosis in children and adolescents (electronic version).WHO; 2022. https://apps.who.int/iris/rest/bitstreams/1414333/retrieve.[QUIS enchiridion operationis de tuberculosis.OMNIBUSV: De administratione tuberculosis in pueris et adolescentibus (versio electronica). OMS; 2022. https://apps.who. int/iris/rest/bitstreams/1414333/retrieve.]
3. Management of children with drug-resistant TB: a practical guide. Boston, USA, Sentinel Project to Combat the Spread of Drug-Resistant TB in Children; November, 2018, 4th edition.http://ftiziatr.org.ua/ftiziatrorgua/docsis/santel-rukovodstvo-rus.pdf [Procuratio puerorum cum medicamento repugnant TB: dux practicus. Boston, USA, Vigil Project ad pugnandum ad propagationemmedi camentorum resistentium TB in Pueris; November, 2018, 4th edition.]
4. Sandgren A, Hollo V, Quinten C, Manissero D. Childhood tuberculosis in the European Union/European Economic Area, 2000 to 2009. Euro Surveill. 2011;16(12): pii=19825. https://www.eurosurveillance.org/images/dynamic/ EE/ V16N12/art19825.pdf.[Sandgren A, Hollo V, Quinten C, Manissero D. Puerilis tuberculosis in Unione Europaea / Area Oeconomica Europaea, MM ad 2009. Euro Surveill. 2011; 16 (12): pii=19825. https://www.eurosurveillance.org/images/dynamic/EE/V16N12/art19825.pdf.]
5. Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Childhood multidrug-resistant tuberculosis in the European Union and European Economic Area:an analysis of tuberculosis surveillance data from 2007 to 2015.Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/. [Kodmon Csaba, van den Boom Martin, Zucs Phillip, van der Werf Marieke Johanna. Puerilia multidrug-repugnantia tuberculosis in Unione Europaea et Area Oeconomica Europaea: analysis custodiae tuberculosis data a 2007 ad 2015. Euro Surveill. 2017;22(47): pii=17-00103. https://doi.org/10.2807/1560-7917. ES.2017.22.47.17-00103/.]
6. WHO operational handbook on tuberculosis. Module 3: diagnosis - rapid diagnostics for tuberculosis detention, 2021.
https://apps.who.int/iris/rest/ bitstreams/1354706/retrieve [QUIS de tuberculosis enchiridion perficiendis. Module 3: diagnosis -celeri diagnostica ad tuberculosis detentionem, 2021. https://apps.who.int/iris/rest/bitstreams/1354706/ retrieve]
7. WHO consolidated guidelines on tuberculosis. Module 5: management of tuberculosis in children and adolescents. WHO; 2022. https:// apps. who. int/ iris/rest/ bit streams/1414329/retrieve [QUAE normas tuberculosis contexuerunt. OMNIBUS V: De administratione tuberculosis in pueris et adolescentibus. OMS; 2022. https://apps. OMS. int/iris/requie/bit riui/1414329/retrieve]
8. Cordova J, Shiloh R, Gilman RH, et al. Evaluation of molecular tools for detection and drug susceptibility testing of Mycobacterium tuberculosis in stool specimens from patients with pulmonary tuberculosis. J Clin Microbiol 2010; 48: 1820–1826. http://dx. doi.org/10.1128/JCM.01161-09 [Cordubae J, Silo R, Gilman RH, et al. Aestimatio instrumentorum hypotheticorum pro deprehensioneet medicamento susceptibilitate probationis Mycobacterii tuberculosis in speciminibus aegri ab aegris cum tuberculosis pulmonis. J Clin Microbiol 2010; 48: 1820-1826. http://dx.doi.org/10.1128/JCM.01161-09]
9. Walters E, van der Zalm MM, Palmer M, et al.Xpert MTB/RIF on stool is useful for the rapid diagnosis of tuberculosis in young children with severe pulmonary disease. Pediatr Infect Dis J 2017; 36: 837–843. https: //pubmed. ncbi.nlm. nih. gov/ 28151842/[Walters E, van der Zalm MM, Palmer M, et al Xpert MTB/RIF in alvus utilis est celeri diagnosi tuberculosis infantum cum gravi morbo pulmonali. Pediatr Infect Dis J 2017; 36: 837-843. https: // pubmed. ncbi.nlm. nih. gov/ 28151842/]
10. Marcy O, Ung V, Goyet S, et al. Performance of Xpert MTB/RIF and alternative specimen collection methods for the diagnosis of tuberculosis in HIV-infected children. Clin Infect Dis 2016; 62: 1161–1168.CrossRefPubMedGoogle Scholar. https://pubmed.ncbi.nlm.nih.gov/26908804/[Marcy O, Ung V, Goyet S, et al. Effectus Xpert MTB/RIF et alternative methodi speciminis collectionis diagnosis tuberculosis in pueris HIV-infectis. Clin Infect Dis 2016; 62: 1161–1168. CrossRefPubMedGoogle Scholar. https://pubmed. ncbi.nlm.nih.gov/26908804/]
Цитата үчүн

Курманова Н.К., Калманбетова Г.И., Матаева Г.К., Азыкова А.Б. Балдардын кургак учугун оорусундагы патологиялык материалдын ар түрдүү үлгөлөрүнүн лабораториалык түрдө диагностикалоонун
маалыматуулугу. Кыргызстандын саламаттык сактоо 2022, no 2, б. 58-64.  https://dx.doi.org/10.51350/zdravkg202262758
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