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Features of general blood analysis parameters associated with the development of contrast-induced nephropathy in patients with coronary heart disease

https://dx.doi.org/10.51350/zdravkg2025.1.3.3.24.31
Features of general blood analysis parameters associated with the development of contrast-induced nephropathy in patients with coronary heart disease
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Abstract About the authors References

Abstract

Introduction. The development of acute renal failure due to contrast-induced nephropathy is a factor that worsens the overall prognosis and requires timely correction of modifiable risk factors and preventive measures. Purpose of the study. To study the relationship between complete blood cell count parameters and the development of contrast-induced nephropathy in patients with coronary heart disease after endovascular interventions. Materials and research methods. The study included 184 patients who underwent inpatient treatment in the clinical departments of the National сenter for сardiology and therapy named after academician Mirsaid Mirrakhimov under the Ministry of Health of the Kyrgyz Republic. The age of the patients ranged from 30 to 70 years (mean age was 55,2±8,5 years). Of the surveyed men, there were 132 (71,7%), and women - 52 (28,3%). All patients suffered from various forms of coronary heart disease. Patients underwent a general clinical examination, anthropometric and biochemical studies, including the determination of a diffuse complete blood count, as well as electrocardiography, echocardiography, ultrasound examination of the kidneys and coronary angiography. All patients were assessed for the risk of developing contrast-induced nephropathy according to the R. Mehran scale (2004). Results. 32 (17.4%) of 184 patients included in the study developed CIN. The performed logistic regression analysis showed that independent factors associated with the development of CIN in patients with endovascular interventions include: acute myocardial infarction - (RR 3.98; 95% CI 1,05 - 16,6), diabetes mellitus (RR – 5,47; 95% CI 2,9 – 10,1) and an increase in the number of leukocytes (RR – 1,33; 95% CI 1.02 - 1.74). Conclusion. An increase in the number of leukocytes is an independent risk factor for the development of contrast-induced nephropathy in patients with coronary heart disease after endovascular intervention.

About the authors

Сагынбаева Гулзира Аскарбековна, ассистент кафедры факультетской терапии Кыргызской государственной медицинская академия им. И.К. Ахунбаева, Бишкек, Кыргызская Республика
Мураталиев Тулкун Мураталиевич, доктор медицинских наук, профессор, кафедры кардиохирургии и эндоваскулярной хирургии Кыргызской государственной медицинская академия им. И.К. Ахунбаева, Бишкек, Кыргызская Республика

Калиев Рысбек Рысмамбетович, доктор медицинских наук, профессор, кафедры факультетской терапии Кыргызской государственной медицинская академия им. И.К. Ахунбаева, Бишкек, Кыргызская Республика

Sagynbaeva Gulzira Askarbekovna, assistant of the department of faculty therapy of the Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyz Republic
Murataliev Tulkun Muratalievich, Doctor of Medical Sciences, Professor, Department of Cardiac Surgery and Endovascular Surgery, Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyz Republic

Kaliev Rysbek Rysmambetovich, Doctor of Medical Sciences, Professor, Department of Faculty Therapy, Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyz Republic

Сагынбаева Гүлзира Аскарбековна, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын факультеттик терапия кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы
Мураталиев Тулкун Мураталиевич, медицина илимдеринин доктору, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын кардиохирургия жана эндоваскулярдык хирургия кафедрасынын профессору, Бишкек, Кыргыз Республикасы

Калиев Рысбек Рысмамбетович, медицина илимдеринин доктору, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын факультеттик терапия кафедрасынын профессору, Бишкек, Кыргыз Республикасы

References

1. Shusterman, M.D. Risk Factors and outcome of hospital-acquired acute renal failure. Clinical epidemiologic study. M.D. Shusterman, L. Brian, M.D. Strom, G. Thomas, M.D. Murray, M.D. GailMorrison, L. Suzanne, M.P.H. West. The American Journal of Medicine. - 1987. – Vol. 83, № 1. – P. 65 - 71. DOI: 10.1016/0002-9343(87)90498-0
2. McCullough, P.A. Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality / P.A. Mc Cullough, R. Wolyn, L.L. Rocher, R.N. Levin, W.W. O'Neill // The American Journal of Medicine. – 1997. – Vol.103, № 5. –P. 368 - 375. doi: 10.1016/s0002-9343(97)00150-2.
3. Bartholomew, B.A. Impact of nephropathy after percutaneous coronary intervention and a metod for risk stratification / B.A. Bartholomew, K.J. Harjai, S. Dukkipati, J.A. Boura, M.W.Yerkey, S.Glazier, С.L. Grines, W.W. O'Neill // American Journal of Cardiology. – 2004. – Vol.93. - № 12. –P. 1515-1519. doi: 10.1016/j.amjcard.2004.03.008.PMID: 15194023
4. Brown, J.R. Serious renal dysfunction after percutaneous coronary intervention can be predicted / J.R. Brown, J.T. DeVries, D.Winthrop, W.P. Piper, J.F. Robb, M.J. Hearne, M.A.Ver Lee Kellet, M.W. Watkins, T.J. Ryan, M.T. Silver // American Heart journal. - 2008. – Vol.155, № 2. – P. 260 - 266.
5. Rihal, C.S. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention / C.S. Rihal, S.C.Textor, D.E. Grill, P.B. Berger, H.H.Ting, P.J. Best, M. Singh, M.R. Bell, G.W. Barsness, V.Mathew, K.N. Garratt, D.R. Holmes // Circulation. – 2002. – Vol. 105, №19. - P. 2259-2264. doi: 10.1161/01.cir.0000016043.87291.33.
6. Toprak, O. Risk markers for contrast-indused nephropathy /O. Toprak // The American Journal of Medicine at Science. –2007. – Vol. 334, № 4. – P. 283-290. doi: 10.1097/MAJ.0b013e318068ddf9.
7. Сагынбаева, Г.А. Контраст - индуцированное острое повреждение почек. Факторы риска. Литературный обзор / Г.А. Сагынбаева, Т.М. Ибрагимова, В.К. Звенцова, Р.Р. Калиев // Вестник КГМА им. И.К. Ахунбаева. - 2015. – Vol.4. –P.123 –127.
8. Levey, A.S. New Equation to Estimate Glomerular Filtration Rate /A.S. Levey, L.A. Stevens, C.H. Schmid, Y.L. Zhang, A.F. Castro, H.I. Feldman, J.W. Kusek, P. Eggers, F.Van Lente, T. Greene, J. Coresh //Annals of Internal Medicine. – 2009. – Vol. 150, № 9. – P.604 – 612.
9. Mehran, R. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: devel opment and initial validation /R. Mehran, E.D. Aymong, E. Nikolsky, Z. Lasic, I. Iakovou, M. Fahy, G.S Mintz, A. J. Lansky, J.W. Moses, G.W. Stone, M.B. Leon, G. Dangas // Journal of the American College of Cardiology. – 2004. – Vol. 44, № 7. – P.1393-1399. doi: 10.1016/j.jacc.2004.06.068.
10. Berns A.S. Nephrotoxicity of contrast media / Berns A.S.// Kidney International. - 1989. – Vol. 36, № 4. – P.730 - 740. doi:10.1038/ki.1989.254.
11. Rich, M.W. Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study / M.W. Rich, C.A. Crecelius // Archives of internal medicine. – 1990. – Vol.150, №6. – P.1237-1242.
12. Ying,Y. Predictive value of inflammatory factors on contrast-induced acute kidney injury in patients who underwent an emergency percutaneous coronary intervention / Y.Ying, Q. Hong, H. Xiaoying, L. Tong, G. Xiaojin, Zh. Xueyan, Zh. Jun, W. Yuan, Q. Shubin, Y.Yuejin, G. Runlin // Clinical Cardiology. – 2017. – Vol. 40, № 9. – P.719-725. doi: 10.1002/clc.22722.
13. Zorlu, C. Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome After Coronary Angiography / C. Zorlu, C. Koseoglu // Angiology. – 2020. – Vol. 71, № 3. – P. 249-255. doi: 10.1177/0003319719892160.
14. Jie, J. Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome? A systematic review and meta-analysis / J. Jie, J. Hong-Yan, X. Wei-Ming, R. Lu-Sen, Ch. Yu-Si, Zh. Cun-Tai, Q. Xiao-Qing //Medicine (Baltimore). – 2019. –Vol.98, № 32. – P.1-10. doi: 10.1097/MD.0000000000016801.
15. Hudzik, B. Platelet-to-lymphocyte ratio predicts contrast -induced acute kidney injury in diabetic patients with ST-elevation myocardial infarction /В.Hudzik, J. Szkodziński, I. Korzonek-Szlacheta, K. Wilczek, M.Gierlotka, А. Lekston, В. Zubelewicz- Szkodzińska, M. Gąsior // Biomarkers in Medicine. – 2017. – Vol.11, № 10. – P. 847-856. doi: 10.2217/bmm-2017-0120.
16. Relation of red cell distribution width to contrast – induced acute kidney injury in patients undergoing a primary percutaneous coronary intervention [Текст] / [F. Akin, O. Celik, I. Altun et al.]. – Coronary artery disease, 2015. – Vol.26. – № 4. – P. 289 –295.
17. Platelet-to-lymphocyte ratio predicts contrast-induced nephropathy in patients with Non – ST– segment elevation acute coronary syndrome [Текст] / [C. Kocas, A. Yildiz, O Abaci et al.]. – Angiology, 2015. – Vol.66. – P. 964 – 968.
18. Platelet to lymphocyte ratio predicts contrast-induced nephropathy in patients with ST – segment elevation myocardial infarction undergoing primary percutaneous coronary intervention [Текст] / [X. P. Sun, J. Li, W. W. Zhu et al.]. – Angiology, 2018. –Vol. 69. – №.1. – P. 71–78.

1. Shusterman, M.D. Risk Factors and outcome of hospital-acquired acute renal failure. Clinical epidemiologic study. M.D. Shusterman, L. Brian, M.D. Strom, G. Thomas, M.D. Murray, M.D. GailMorrison, L. Suzanne, M.P.H. West. The American Journal of Medicine. - 1987. – Vol. 83, № 1. – P. 65 - 71. DOI: 10.1016/0002-9343(87)90498-0
2. McCullough, P.A. Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality / P.A. Mc Cullough, R. Wolyn, L.L. Rocher, R.N. Levin, W.W. O'Neill // The American Journal of Medicine. – 1997. – Vol.103, № 5. –P. 368 - 375. doi: 10.1016/s0002-9343(97)00150-2.
3. Bartholomew, B.A. Impact of nephropathy after percutaneous coronary intervention and a metod for risk stratification / B.A. Bartholomew, K.J. Harjai, S. Dukkipati, J.A. Boura, M.W.Yerkey, S.Glazier, С.L. Grines, W.W. O'Neill // American Journal of Cardiology. – 2004. – Vol.93. - № 12. – P. 1515-1519. doi: 10.1016/j.amjcard.2004.03.008.PMID: 15194023
4. Brown, J.R. Serious renal dysfunction after percutaneous coronary intervention can be predicted / J.R. Brown, J.T. DeVries, D.Winthrop, W.P. Piper, J.F. Robb, M.J. Hearne, M.A.Ver Lee Kellet, M.W. Watkins, T.J. Ryan, M.T. Silver // American Heart journal. - 2008. – Vol.155, № 2. – P. 260 - 266.
5. Rihal, C.S. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention / C.S. Rihal, S.C.Textor, D.E. Grill, P.B. Berger, H.H.Ting, P.J. Best, M. Singh, M.R. Bell, G.W. Barsness, V.Mathew, K.N. Garratt, D.R. Holmes // Circulation. – 2002. – Vol. 105, №19. - P. 2259-2264. doi: 10.1161/01.cir.0000016043.87291.33.
6. Toprak, O. Risk markers for contrast-indused nephropathy /O. Toprak // The American Journal of Medicine at Science. –
2007. – Vol. 334, № 4. – P. 283-290. doi: 10.1097/MAJ.0b013e318068ddf9.
7. Сагынбаева, Г.А. Контраст - индуцированное острое повреждение почек. Факторы риска. Литературный обзор / Г.А. Сагынбаева, Т.М. Ибрагимова, В.К. Звенцова, Р.Р. Калиев // Вестник КГМА им. И.К. Ахунбаева. - 2015. – Vol.4. –P.123 –127.
8. Levey, A.S. New Equation to Estimate Glomerular Filtration Rate /A.S. Levey, L.A. Stevens, C.H. Schmid, Y.L. Zhang, A.F. Castro, H.I. Feldman, J.W. Kusek, P. Eggers, F.Van Lente, T. Greene, J. Coresh //Annals of Internal Medicine. – 2009. – Vol. 150, № 9. – P.604 – 612.
9. Mehran, R. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: devel opment and initial validation /R. Mehran, E.D. Aymong, E. Nikolsky, Z. Lasic, I. Iakovou, M. Fahy, G.S Mintz, A. J. Lansky, J.W. Moses, G.W. Stone, M.B. Leon, G. Dangas // Journal of the American College of Cardiology. – 2004. – Vol. 44, № 7. – P.1393-1399. doi: 10.1016/j.jacc.2004.06.068.
10. Berns A.S. Nephrotoxicity of contrast media / Berns A.S.// Kidney International. - 1989. – Vol. 36, № 4. – P.730 - 740. doi:10.1038/ki.1989.254.
11. Rich, M.W. Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study / M.W. Rich, C.A. Crecelius // Archives of internal medicine. – 1990. – Vol.150, №6. – P.1237-1242.
12. Ying,Y. Predictive value of inflammatory factors on contrast-induced acute kidney injury in patients who underwent an emergency percutaneous coronary intervention / Y.Ying, Q. Hong, H. Xiaoying, L. Tong, G. Xiaojin, Zh. Xueyan, Zh. Jun, W. Yuan, Q. Shubin, Y.Yuejin, G. Runlin // Clinical Cardiology. – 2017. – Vol. 40, № 9. – P.719-725. doi: 10.1002/clc.22722.
13. Zorlu, C. Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome After Coronary Angiography / C. Zorlu, C. Koseoglu // Angiology. – 2020. – Vol. 71, № 3. – P. 249-255. doi: 10.1177/0003319719892160.
14. Jie, J. Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome? A systematic review and meta-analysis / J. Jie, J. Hong-Yan, X. Wei-Ming, R. Lu-Sen, Ch. Yu-Si, Zh. Cun-Tai, Q. Xiao-Qing //Medicine (Baltimore). – 2019. –Vol.98, № 32. – P.1-10. doi: 10.1097/MD.0000000000016801.
15. Hudzik, B. Platelet-to-lymphocyte ratio predicts contrast -induced acute kidney injury in diabetic patients with ST-elevation myocardial infarction /В.Hudzik, J. Szkodziński, I. Korzonek-Szlacheta, K. Wilczek, M.Gierlotka, А. Lekston, В. Zubelewicz- Szkodzińska, M. Gąsior // Biomarkers in Medicine. – 2017. – Vol.11, № 10. – P. 847-856. doi: 10.2217/bmm-2017-0120.
16. Relation of red cell distribution width to contrast – induced acute kidney injury in patients undergoing a primary percutaneous coronary intervention [Текст] / [F. Akin, O. Celik, I. Altun et al.]. – Coronary artery disease, 2015. – Vol.26. – № 4. – P. 289 –295.
17. Platelet-to-lymphocyte ratio predicts contrast-induced nephropathy in patients with Non – ST– segment elevation acute coronary syndrome [Текст] / [C. Kocas, A. Yildiz, O Abaci et al.]. – Angiology, 2015. – Vol.66. – P. 964 – 968.
18. Platelet to lymphocyte ratio predicts contrast-induced nephropathy in patients with ST – segment elevation myocardial infarction undergoing primary percutaneous coronary intervention [Текст] / [X. P. Sun, J. Li, W. W. Zhu et al.]. – Angiology, 2018. –Vol. 69. – №.1. – P. 71–78.

1. Shusterman, M.D. Risk Factors and outcome of hospital-acquired acute renal failure. Clinical epidemiologic study. M.D. Shusterman, L. Brian, M.D. Strom, G. Thomas, M.D. Murray, M.D. GailMorrison, L. Suzanne, M.P.H. West. The American Journal of Medicine. - 1987. – Vol. 83, № 1. – P. 65 - 71. DOI: 10.1016/0002-9343(87)90498-0
2. McCullough, P.A. Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality / P.A. Mc Cullough, R. Wolyn, L.L. Rocher, R.N. Levin, W.W. O'Neill // The American Journal of Medicine. – 1997. – Vol.103, № 5. –P. 368 - 375. doi: 10.1016/s0002-9343(97)00150-2.
3. Bartholomew, B.A. Impact of nephropathy after percutaneous coronary intervention and a metod for risk stratification / B.A. Bartholomew, K.J. Harjai, S. Dukkipati, J.A. Boura, M.W.Yerkey, S.Glazier, С.L. Grines, W.W. O'Neill // American Journal of Cardiology. – 2004. – Vol.93. - № 12. – P. 1515-1519. doi: 10.1016/j.amjcard.2004.03.008.PMID: 15194023
4. Brown, J.R. Serious renal dysfunction after percutaneous coronary intervention can be predicted / J.R. Brown, J.T. DeVries, D.Winthrop, W.P. Piper, J.F. Robb, M.J. Hearne, M.A.Ver Lee Kellet, M.W. Watkins, T.J. Ryan, M.T. Silver // American Heart journal. - 2008. – Vol.155, № 2. – P. 260 - 266.
5. Rihal, C.S. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention / C.S. Rihal, S.C.Textor, D.E. Grill, P.B. Berger, H.H.Ting, P.J. Best, M. Singh, M.R. Bell, G.W. Barsness, V.Mathew, K.N. Garratt, D.R. Holmes // Circulation. – 2002. – Vol. 105, №19. - P. 2259-2264. doi: 10.1161/01.cir.0000016043.87291.33.
6. Toprak, O. Risk markers for contrast-indused nephropathy /O. Toprak // The American Journal of Medicine at Science. –
2007. – Vol. 334, № 4. – P. 283-290. doi: 10.1097/MAJ.0b013e318068ddf9.
7. Сагынбаева, Г.А. Контраст - индуцированное острое повреждение почек. Факторы риска. Литературный обзор / Г.А. Сагынбаева, Т.М. Ибрагимова, В.К. Звенцова, Р.Р. Калиев // Вестник КГМА им. И.К. Ахунбаева. - 2015. – Vol.4. –P.123 –127.
8. Levey, A.S. New Equation to Estimate Glomerular Filtration Rate /A.S. Levey, L.A. Stevens, C.H. Schmid, Y.L. Zhang, A.F. Castro, H.I. Feldman, J.W. Kusek, P. Eggers, F.Van Lente, T. Greene, J. Coresh //Annals of Internal Medicine. – 2009. – Vol. 150, № 9. – P.604 – 612.
9. Mehran, R. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: devel opment and initial validation /R. Mehran, E.D. Aymong, E. Nikolsky, Z. Lasic, I. Iakovou, M. Fahy, G.S Mintz, A. J. Lansky, J.W. Moses, G.W. Stone, M.B. Leon, G. Dangas // Journal of the American College of Cardiology. – 2004. – Vol. 44, № 7. – P.1393-1399. doi: 10.1016/j.jacc.2004.06.068.
10. Berns A.S. Nephrotoxicity of contrast media / Berns A.S.// Kidney International. - 1989. – Vol. 36, № 4. – P.730 - 740. doi:10.1038/ki.1989.254.
11. Rich, M.W. Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study / M.W. Rich, C.A. Crecelius // Archives of internal medicine. – 1990. – Vol.150, №6. – P.1237-1242.
12. Ying,Y. Predictive value of inflammatory factors on contrast-induced acute kidney injury in patients who underwent an emergency percutaneous coronary intervention / Y.Ying, Q. Hong, H. Xiaoying, L. Tong, G. Xiaojin, Zh. Xueyan, Zh. Jun, W. Yuan, Q. Shubin, Y.Yuejin, G. Runlin // Clinical Cardiology. – 2017. – Vol. 40, № 9. – P.719-725. doi: 10.1002/clc.22722.
13. Zorlu, C. Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome After Coronary Angiography / C. Zorlu, C. Koseoglu // Angiology. – 2020. – Vol. 71, № 3. – P. 249-255. doi: 10.1177/0003319719892160.
14. Jie, J. Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome? A systematic review and meta-analysis / J. Jie, J. Hong-Yan, X. Wei-Ming, R. Lu-Sen, Ch. Yu-Si, Zh. Cun-Tai, Q. Xiao-Qing //Medicine (Baltimore). – 2019. –Vol.98, № 32. – P.1-10. doi: 10.1097/MD.0000000000016801.
15. Hudzik, B. Platelet-to-lymphocyte ratio predicts contrast -induced acute kidney injury in diabetic patients with ST-elevation myocardial infarction /В.Hudzik, J. Szkodziński, I. Korzonek-Szlacheta, K. Wilczek, M.Gierlotka, А. Lekston, В. Zubelewicz- Szkodzińska, M. Gąsior // Biomarkers in Medicine. – 2017. – Vol.11, № 10. – P. 847-856. doi: 10.2217/bmm-2017-0120.
16. Relation of red cell distribution width to contrast – induced acute kidney injury in patients undergoing a primary percutaneous coronary intervention [Текст] / [F. Akin, O. Celik, I. Altun et al.]. – Coronary artery disease, 2015. – Vol.26. – № 4. – P. 289 –295.
17. Platelet-to-lymphocyte ratio predicts contrast-induced nephropathy in patients with Non – ST– segment elevation acute coronary syndrome [Текст] / [C. Kocas, A. Yildiz, O Abaci et al.]. – Angiology, 2015. – Vol.66. – P. 964 – 968.
18. Platelet to lymphocyte ratio predicts contrast-induced nephropathy in patients with ST – segment elevation myocardial infarction undergoing primary percutaneous coronary intervention [Текст] / [X. P. Sun, J. Li, W. W. Zhu et al.]. – Angiology, 2018. –Vol. 69. – №.1. – P. 71–78.

Keywords
Risk factors , Leukocytes , Contrast-induced nephropathy , Coronary heart disease , Inflammation
Для цитирования

Сагынбаева Г.А., Мураталиев Т.М., Калиев Р.Р. Особенности показателей общего анализа крови, ассоциированные с развитием контраст-индуцированной нефропатии у больных коронарной болезнью сердца. Научно-практический журнал «Здравоохранение Кыргызстана» 2025, № 1, с. 24-31.  https://dx.doi.org/10.51350/zdravkg2025.1.3.3.24.31 
For citation

Sagynbaeva G.A., Murataliev T.M., Kaliev R.R. Features of general blood analysis parameters associated with the development of contrast-induced nephropathy in patients with coronary heart disease Scientific and practical journal “Health care of Kyrgyzstan” 2025, No.1, p. 24-31. https://dx.doi.org/10.51350/zdravkg2025.1.3.3.24.31 
Цитата үчүн

Сагынбаева Г.А., Мураталиев Т.М., Калиев Р.Р. Коронардык артерия оорусу менен ооруган бейтаптарда контрасттык
нефропатиянын өнүгүшү менен байланышкан жалпы кан анализинин көрсөткүчтөрүнүн өзгөчөлүктөрү. Кыргызстандын саламаттык сактоо илимий-практикалык журналы 2025, № 1, б. 24-31.  https://dx.doi.org/10.51350/zdravkg2025.1.3.3.24.31 
Authors Sagynbaeva G.A., Murataliev T.M., Kaliev R.R.
Link doi.org https://dx.doi.org/10.51350/zdravkg2025.1.3.3.24.31
Pages 24-31
Keywords Risk factors, Leukocytes, Contrast-induced nephropathy , Coronary heart disease , Inflammation
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Об авторах

Сагынбаева Гулзира Аскарбековна, ассистент кафедры факультетской терапии Кыргызской государственной медицинская академия им. И.К. Ахунбаева, Бишкек, Кыргызская Республика
Мураталиев Тулкун Мураталиевич, доктор медицинских наук, профессор, кафедры кардиохирургии и эндоваскулярной хирургии Кыргызской государственной медицинская академия им. И.К. Ахунбаева, Бишкек, Кыргызская Республика

Калиев Рысбек Рысмамбетович, доктор медицинских наук, профессор, кафедры факультетской терапии Кыргызской государственной медицинская академия им. И.К. Ахунбаева, Бишкек, Кыргызская Республика

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Список литературы

1. Shusterman, M.D. Risk Factors and outcome of hospital-acquired acute renal failure. Clinical epidemiologic study. M.D. Shusterman, L. Brian, M.D. Strom, G. Thomas, M.D. Murray, M.D. GailMorrison, L. Suzanne, M.P.H. West. The American Journal of Medicine. - 1987. – Vol. 83, № 1. – P. 65 - 71. DOI: 10.1016/0002-9343(87)90498-0
2. McCullough, P.A. Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality / P.A. Mc Cullough, R. Wolyn, L.L. Rocher, R.N. Levin, W.W. O'Neill // The American Journal of Medicine. – 1997. – Vol.103, № 5. –P. 368 - 375. doi: 10.1016/s0002-9343(97)00150-2.
3. Bartholomew, B.A. Impact of nephropathy after percutaneous coronary intervention and a metod for risk stratification / B.A. Bartholomew, K.J. Harjai, S. Dukkipati, J.A. Boura, M.W.Yerkey, S.Glazier, С.L. Grines, W.W. O'Neill // American Journal of Cardiology. – 2004. – Vol.93. - № 12. –P. 1515-1519. doi: 10.1016/j.amjcard.2004.03.008.PMID: 15194023
4. Brown, J.R. Serious renal dysfunction after percutaneous coronary intervention can be predicted / J.R. Brown, J.T. DeVries, D.Winthrop, W.P. Piper, J.F. Robb, M.J. Hearne, M.A.Ver Lee Kellet, M.W. Watkins, T.J. Ryan, M.T. Silver // American Heart journal. - 2008. – Vol.155, № 2. – P. 260 - 266.
5. Rihal, C.S. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention / C.S. Rihal, S.C.Textor, D.E. Grill, P.B. Berger, H.H.Ting, P.J. Best, M. Singh, M.R. Bell, G.W. Barsness, V.Mathew, K.N. Garratt, D.R. Holmes // Circulation. – 2002. – Vol. 105, №19. - P. 2259-2264. doi: 10.1161/01.cir.0000016043.87291.33.
6. Toprak, O. Risk markers for contrast-indused nephropathy /O. Toprak // The American Journal of Medicine at Science. –2007. – Vol. 334, № 4. – P. 283-290. doi: 10.1097/MAJ.0b013e318068ddf9.
7. Сагынбаева, Г.А. Контраст - индуцированное острое повреждение почек. Факторы риска. Литературный обзор / Г.А. Сагынбаева, Т.М. Ибрагимова, В.К. Звенцова, Р.Р. Калиев // Вестник КГМА им. И.К. Ахунбаева. - 2015. – Vol.4. –P.123 –127.
8. Levey, A.S. New Equation to Estimate Glomerular Filtration Rate /A.S. Levey, L.A. Stevens, C.H. Schmid, Y.L. Zhang, A.F. Castro, H.I. Feldman, J.W. Kusek, P. Eggers, F.Van Lente, T. Greene, J. Coresh //Annals of Internal Medicine. – 2009. – Vol. 150, № 9. – P.604 – 612.
9. Mehran, R. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: devel opment and initial validation /R. Mehran, E.D. Aymong, E. Nikolsky, Z. Lasic, I. Iakovou, M. Fahy, G.S Mintz, A. J. Lansky, J.W. Moses, G.W. Stone, M.B. Leon, G. Dangas // Journal of the American College of Cardiology. – 2004. – Vol. 44, № 7. – P.1393-1399. doi: 10.1016/j.jacc.2004.06.068.
10. Berns A.S. Nephrotoxicity of contrast media / Berns A.S.// Kidney International. - 1989. – Vol. 36, № 4. – P.730 - 740. doi:10.1038/ki.1989.254.
11. Rich, M.W. Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study / M.W. Rich, C.A. Crecelius // Archives of internal medicine. – 1990. – Vol.150, №6. – P.1237-1242.
12. Ying,Y. Predictive value of inflammatory factors on contrast-induced acute kidney injury in patients who underwent an emergency percutaneous coronary intervention / Y.Ying, Q. Hong, H. Xiaoying, L. Tong, G. Xiaojin, Zh. Xueyan, Zh. Jun, W. Yuan, Q. Shubin, Y.Yuejin, G. Runlin // Clinical Cardiology. – 2017. – Vol. 40, № 9. – P.719-725. doi: 10.1002/clc.22722.
13. Zorlu, C. Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome After Coronary Angiography / C. Zorlu, C. Koseoglu // Angiology. – 2020. – Vol. 71, № 3. – P. 249-255. doi: 10.1177/0003319719892160.
14. Jie, J. Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome? A systematic review and meta-analysis / J. Jie, J. Hong-Yan, X. Wei-Ming, R. Lu-Sen, Ch. Yu-Si, Zh. Cun-Tai, Q. Xiao-Qing //Medicine (Baltimore). – 2019. –Vol.98, № 32. – P.1-10. doi: 10.1097/MD.0000000000016801.
15. Hudzik, B. Platelet-to-lymphocyte ratio predicts contrast -induced acute kidney injury in diabetic patients with ST-elevation myocardial infarction /В.Hudzik, J. Szkodziński, I. Korzonek-Szlacheta, K. Wilczek, M.Gierlotka, А. Lekston, В. Zubelewicz- Szkodzińska, M. Gąsior // Biomarkers in Medicine. – 2017. – Vol.11, № 10. – P. 847-856. doi: 10.2217/bmm-2017-0120.
16. Relation of red cell distribution width to contrast – induced acute kidney injury in patients undergoing a primary percutaneous coronary intervention [Текст] / [F. Akin, O. Celik, I. Altun et al.]. – Coronary artery disease, 2015. – Vol.26. – № 4. – P. 289 –295.
17. Platelet-to-lymphocyte ratio predicts contrast-induced nephropathy in patients with Non – ST– segment elevation acute coronary syndrome [Текст] / [C. Kocas, A. Yildiz, O Abaci et al.]. – Angiology, 2015. – Vol.66. – P. 964 – 968.
18. Platelet to lymphocyte ratio predicts contrast-induced nephropathy in patients with ST – segment elevation myocardial infarction undergoing primary percutaneous coronary intervention [Текст] / [X. P. Sun, J. Li, W. W. Zhu et al.]. – Angiology, 2018. –Vol. 69. – №.1. – P. 71–78.
Для цитирования

Сагынбаева Г.А., Мураталиев Т.М., Калиев Р.Р. Особенности показателей общего анализа крови, ассоциированные с развитием контраст-индуцированной нефропатии у больных коронарной болезнью сердца. Научно-практический журнал «Здравоохранение Кыргызстана» 2025, № 1, с. 24-31.  https://dx.doi.org/10.51350/zdravkg2025.1.3.3.24.31 
English
About authors

Sagynbaeva Gulzira Askarbekovna, assistant of the department of faculty therapy of the Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyz Republic
Murataliev Tulkun Muratalievich, Doctor of Medical Sciences, Professor, Department of Cardiac Surgery and Endovascular Surgery, Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyz Republic

Kaliev Rysbek Rysmambetovich, Doctor of Medical Sciences, Professor, Department of Faculty Therapy, Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyz Republic

References

1. Shusterman, M.D. Risk Factors and outcome of hospital-acquired acute renal failure. Clinical epidemiologic study. M.D. Shusterman, L. Brian, M.D. Strom, G. Thomas, M.D. Murray, M.D. GailMorrison, L. Suzanne, M.P.H. West. The American Journal of Medicine. - 1987. – Vol. 83, № 1. – P. 65 - 71. DOI: 10.1016/0002-9343(87)90498-0
2. McCullough, P.A. Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality / P.A. Mc Cullough, R. Wolyn, L.L. Rocher, R.N. Levin, W.W. O'Neill // The American Journal of Medicine. – 1997. – Vol.103, № 5. –P. 368 - 375. doi: 10.1016/s0002-9343(97)00150-2.
3. Bartholomew, B.A. Impact of nephropathy after percutaneous coronary intervention and a metod for risk stratification / B.A. Bartholomew, K.J. Harjai, S. Dukkipati, J.A. Boura, M.W.Yerkey, S.Glazier, С.L. Grines, W.W. O'Neill // American Journal of Cardiology. – 2004. – Vol.93. - № 12. – P. 1515-1519. doi: 10.1016/j.amjcard.2004.03.008.PMID: 15194023
4. Brown, J.R. Serious renal dysfunction after percutaneous coronary intervention can be predicted / J.R. Brown, J.T. DeVries, D.Winthrop, W.P. Piper, J.F. Robb, M.J. Hearne, M.A.Ver Lee Kellet, M.W. Watkins, T.J. Ryan, M.T. Silver // American Heart journal. - 2008. – Vol.155, № 2. – P. 260 - 266.
5. Rihal, C.S. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention / C.S. Rihal, S.C.Textor, D.E. Grill, P.B. Berger, H.H.Ting, P.J. Best, M. Singh, M.R. Bell, G.W. Barsness, V.Mathew, K.N. Garratt, D.R. Holmes // Circulation. – 2002. – Vol. 105, №19. - P. 2259-2264. doi: 10.1161/01.cir.0000016043.87291.33.
6. Toprak, O. Risk markers for contrast-indused nephropathy /O. Toprak // The American Journal of Medicine at Science. –
2007. – Vol. 334, № 4. – P. 283-290. doi: 10.1097/MAJ.0b013e318068ddf9.
7. Сагынбаева, Г.А. Контраст - индуцированное острое повреждение почек. Факторы риска. Литературный обзор / Г.А. Сагынбаева, Т.М. Ибрагимова, В.К. Звенцова, Р.Р. Калиев // Вестник КГМА им. И.К. Ахунбаева. - 2015. – Vol.4. –P.123 –127.
8. Levey, A.S. New Equation to Estimate Glomerular Filtration Rate /A.S. Levey, L.A. Stevens, C.H. Schmid, Y.L. Zhang, A.F. Castro, H.I. Feldman, J.W. Kusek, P. Eggers, F.Van Lente, T. Greene, J. Coresh //Annals of Internal Medicine. – 2009. – Vol. 150, № 9. – P.604 – 612.
9. Mehran, R. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: devel opment and initial validation /R. Mehran, E.D. Aymong, E. Nikolsky, Z. Lasic, I. Iakovou, M. Fahy, G.S Mintz, A. J. Lansky, J.W. Moses, G.W. Stone, M.B. Leon, G. Dangas // Journal of the American College of Cardiology. – 2004. – Vol. 44, № 7. – P.1393-1399. doi: 10.1016/j.jacc.2004.06.068.
10. Berns A.S. Nephrotoxicity of contrast media / Berns A.S.// Kidney International. - 1989. – Vol. 36, № 4. – P.730 - 740. doi:10.1038/ki.1989.254.
11. Rich, M.W. Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study / M.W. Rich, C.A. Crecelius // Archives of internal medicine. – 1990. – Vol.150, №6. – P.1237-1242.
12. Ying,Y. Predictive value of inflammatory factors on contrast-induced acute kidney injury in patients who underwent an emergency percutaneous coronary intervention / Y.Ying, Q. Hong, H. Xiaoying, L. Tong, G. Xiaojin, Zh. Xueyan, Zh. Jun, W. Yuan, Q. Shubin, Y.Yuejin, G. Runlin // Clinical Cardiology. – 2017. – Vol. 40, № 9. – P.719-725. doi: 10.1002/clc.22722.
13. Zorlu, C. Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome After Coronary Angiography / C. Zorlu, C. Koseoglu // Angiology. – 2020. – Vol. 71, № 3. – P. 249-255. doi: 10.1177/0003319719892160.
14. Jie, J. Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome? A systematic review and meta-analysis / J. Jie, J. Hong-Yan, X. Wei-Ming, R. Lu-Sen, Ch. Yu-Si, Zh. Cun-Tai, Q. Xiao-Qing //Medicine (Baltimore). – 2019. –Vol.98, № 32. – P.1-10. doi: 10.1097/MD.0000000000016801.
15. Hudzik, B. Platelet-to-lymphocyte ratio predicts contrast -induced acute kidney injury in diabetic patients with ST-elevation myocardial infarction /В.Hudzik, J. Szkodziński, I. Korzonek-Szlacheta, K. Wilczek, M.Gierlotka, А. Lekston, В. Zubelewicz- Szkodzińska, M. Gąsior // Biomarkers in Medicine. – 2017. – Vol.11, № 10. – P. 847-856. doi: 10.2217/bmm-2017-0120.
16. Relation of red cell distribution width to contrast – induced acute kidney injury in patients undergoing a primary percutaneous coronary intervention [Текст] / [F. Akin, O. Celik, I. Altun et al.]. – Coronary artery disease, 2015. – Vol.26. – № 4. – P. 289 –295.
17. Platelet-to-lymphocyte ratio predicts contrast-induced nephropathy in patients with Non – ST– segment elevation acute coronary syndrome [Текст] / [C. Kocas, A. Yildiz, O Abaci et al.]. – Angiology, 2015. – Vol.66. – P. 964 – 968.
18. Platelet to lymphocyte ratio predicts contrast-induced nephropathy in patients with ST – segment elevation myocardial infarction undergoing primary percutaneous coronary intervention [Текст] / [X. P. Sun, J. Li, W. W. Zhu et al.]. – Angiology, 2018. –Vol. 69. – №.1. – P. 71–78.
For citation

Sagynbaeva G.A., Murataliev T.M., Kaliev R.R. Features of general blood analysis parameters associated with the development of contrast-induced nephropathy in patients with coronary heart disease Scientific and practical journal “Health care of Kyrgyzstan” 2025, No.1, p. 24-31. https://dx.doi.org/10.51350/zdravkg2025.1.3.3.24.31 
Kyrgyz
Авторлор жөнүндө

Сагынбаева Гүлзира Аскарбековна, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын факультеттик терапия кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы
Мураталиев Тулкун Мураталиевич, медицина илимдеринин доктору, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын кардиохирургия жана эндоваскулярдык хирургия кафедрасынын профессору, Бишкек, Кыргыз Республикасы

Калиев Рысбек Рысмамбетович, медицина илимдеринин доктору, И.К. Ахунбаев атындагы Кыргыз мамлекеттик медициналык академиясынын факультеттик терапия кафедрасынын профессору, Бишкек, Кыргыз Республикасы
Шилтемелер

1. Shusterman, M.D. Risk Factors and outcome of hospital-acquired acute renal failure. Clinical epidemiologic study. M.D. Shusterman, L. Brian, M.D. Strom, G. Thomas, M.D. Murray, M.D. GailMorrison, L. Suzanne, M.P.H. West. The American Journal of Medicine. - 1987. – Vol. 83, № 1. – P. 65 - 71. DOI: 10.1016/0002-9343(87)90498-0
2. McCullough, P.A. Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality / P.A. Mc Cullough, R. Wolyn, L.L. Rocher, R.N. Levin, W.W. O'Neill // The American Journal of Medicine. – 1997. – Vol.103, № 5. –P. 368 - 375. doi: 10.1016/s0002-9343(97)00150-2.
3. Bartholomew, B.A. Impact of nephropathy after percutaneous coronary intervention and a metod for risk stratification / B.A. Bartholomew, K.J. Harjai, S. Dukkipati, J.A. Boura, M.W.Yerkey, S.Glazier, С.L. Grines, W.W. O'Neill // American Journal of Cardiology. – 2004. – Vol.93. - № 12. – P. 1515-1519. doi: 10.1016/j.amjcard.2004.03.008.PMID: 15194023
4. Brown, J.R. Serious renal dysfunction after percutaneous coronary intervention can be predicted / J.R. Brown, J.T. DeVries, D.Winthrop, W.P. Piper, J.F. Robb, M.J. Hearne, M.A.Ver Lee Kellet, M.W. Watkins, T.J. Ryan, M.T. Silver // American Heart journal. - 2008. – Vol.155, № 2. – P. 260 - 266.
5. Rihal, C.S. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention / C.S. Rihal, S.C.Textor, D.E. Grill, P.B. Berger, H.H.Ting, P.J. Best, M. Singh, M.R. Bell, G.W. Barsness, V.Mathew, K.N. Garratt, D.R. Holmes // Circulation. – 2002. – Vol. 105, №19. - P. 2259-2264. doi: 10.1161/01.cir.0000016043.87291.33.
6. Toprak, O. Risk markers for contrast-indused nephropathy /O. Toprak // The American Journal of Medicine at Science. –
2007. – Vol. 334, № 4. – P. 283-290. doi: 10.1097/MAJ.0b013e318068ddf9.
7. Сагынбаева, Г.А. Контраст - индуцированное острое повреждение почек. Факторы риска. Литературный обзор / Г.А. Сагынбаева, Т.М. Ибрагимова, В.К. Звенцова, Р.Р. Калиев // Вестник КГМА им. И.К. Ахунбаева. - 2015. – Vol.4. –P.123 –127.
8. Levey, A.S. New Equation to Estimate Glomerular Filtration Rate /A.S. Levey, L.A. Stevens, C.H. Schmid, Y.L. Zhang, A.F. Castro, H.I. Feldman, J.W. Kusek, P. Eggers, F.Van Lente, T. Greene, J. Coresh //Annals of Internal Medicine. – 2009. – Vol. 150, № 9. – P.604 – 612.
9. Mehran, R. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: devel opment and initial validation /R. Mehran, E.D. Aymong, E. Nikolsky, Z. Lasic, I. Iakovou, M. Fahy, G.S Mintz, A. J. Lansky, J.W. Moses, G.W. Stone, M.B. Leon, G. Dangas // Journal of the American College of Cardiology. – 2004. – Vol. 44, № 7. – P.1393-1399. doi: 10.1016/j.jacc.2004.06.068.
10. Berns A.S. Nephrotoxicity of contrast media / Berns A.S.// Kidney International. - 1989. – Vol. 36, № 4. – P.730 - 740. doi:10.1038/ki.1989.254.
11. Rich, M.W. Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study / M.W. Rich, C.A. Crecelius // Archives of internal medicine. – 1990. – Vol.150, №6. – P.1237-1242.
12. Ying,Y. Predictive value of inflammatory factors on contrast-induced acute kidney injury in patients who underwent an emergency percutaneous coronary intervention / Y.Ying, Q. Hong, H. Xiaoying, L. Tong, G. Xiaojin, Zh. Xueyan, Zh. Jun, W. Yuan, Q. Shubin, Y.Yuejin, G. Runlin // Clinical Cardiology. – 2017. – Vol. 40, № 9. – P.719-725. doi: 10.1002/clc.22722.
13. Zorlu, C. Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome After Coronary Angiography / C. Zorlu, C. Koseoglu // Angiology. – 2020. – Vol. 71, № 3. – P. 249-255. doi: 10.1177/0003319719892160.
14. Jie, J. Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome? A systematic review and meta-analysis / J. Jie, J. Hong-Yan, X. Wei-Ming, R. Lu-Sen, Ch. Yu-Si, Zh. Cun-Tai, Q. Xiao-Qing //Medicine (Baltimore). – 2019. –Vol.98, № 32. – P.1-10. doi: 10.1097/MD.0000000000016801.
15. Hudzik, B. Platelet-to-lymphocyte ratio predicts contrast -induced acute kidney injury in diabetic patients with ST-elevation myocardial infarction /В.Hudzik, J. Szkodziński, I. Korzonek-Szlacheta, K. Wilczek, M.Gierlotka, А. Lekston, В. Zubelewicz- Szkodzińska, M. Gąsior // Biomarkers in Medicine. – 2017. – Vol.11, № 10. – P. 847-856. doi: 10.2217/bmm-2017-0120.
16. Relation of red cell distribution width to contrast – induced acute kidney injury in patients undergoing a primary percutaneous coronary intervention [Текст] / [F. Akin, O. Celik, I. Altun et al.]. – Coronary artery disease, 2015. – Vol.26. – № 4. – P. 289 –295.
17. Platelet-to-lymphocyte ratio predicts contrast-induced nephropathy in patients with Non – ST– segment elevation acute coronary syndrome [Текст] / [C. Kocas, A. Yildiz, O Abaci et al.]. – Angiology, 2015. – Vol.66. – P. 964 – 968.
18. Platelet to lymphocyte ratio predicts contrast-induced nephropathy in patients with ST – segment elevation myocardial infarction undergoing primary percutaneous coronary intervention [Текст] / [X. P. Sun, J. Li, W. W. Zhu et al.]. – Angiology, 2018. –Vol. 69. – №.1. – P. 71–78.
Цитата үчүн

Сагынбаева Г.А., Мураталиев Т.М., Калиев Р.Р. Коронардык артерия оорусу менен ооруган бейтаптарда контрасттык
нефропатиянын өнүгүшү менен байланышкан жалпы кан анализинин көрсөткүчтөрүнүн өзгөчөлүктөрү. Кыргызстандын саламаттык сактоо илимий-практикалык журналы 2025, № 1, б. 24-31.  https://dx.doi.org/10.51350/zdravkg2025.1.3.3.24.31 
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