# 1 (2022)

Our study demonstrates the data of total cholesterol (TC) level in the blood of persons with diabetes who are
registered in the Family Medicine Centers (FMC) of Bishkek. The main cause of CVD in DM is atherosclerosis. Insulin
resistance and associated hyperinsulinemia, which has a direct atherogenic effect on the vascular wall, play a significant
role in the pathogenesis of DM2. Therefore, the strategy of CVD prevention in patients with DM, along with achieving
the targets glycemia (which are fundamental for the prevention of microvascular complications), should be based on correction
of risk factors for microvascular diseases, as primarily dyslipidemia. According to all international recommendations,
the control of blood lipids is no less important than the control of glycemia and blood pressure.
During the year, the TC was examined in 2,182 (49.1%) persons with diabetes, its average indicators were within the
target values. However, this indicator was examined unevenly in FMC, 50.9% of patients with DM were left without
control of lipid profile. Primary care doctors did not always prescribe blood cholesterol determination to patients, although
this examination is available free of charge in all PHC laboratories in Kyrgyzstan.
In 33% of patients with DM in CSM, who were included in the group, the frequency of cholesterol determination during
the year reached 5-10 times, which is economically impractical and wasteful.

Introduction. In the scientific work, the analysis of the results of the examination of 116 men who applied to
the Republican Scientific center of urology at the National hospital of the Ministry of Health of the Kyrgyz republic for
epididymal cyst. The circulation period falls on 2017-2021. Purpose of the study. To evaluate the effectiveness of aceclofenac
on the level of tumor necrosis factor alpha, interleukin 6 and 4 in patients with epididymal cyst. Materials and
methods. For the diagnosis, the collection of anamnestic data was used for patients with epididymal cyst . All men were
examined by ultrasound. Ultrasound examination was performed using the WED 9608 apparatus with a high-frequency
probe and Doppler sonography. The levels of interleukin - 6, interleukin - 4 and tumor necrosis factor alpha were determined
in the blood and cystic fluid. The fluid was obtained during surgical excision of cysts, it was examined by immunometric
analysis using mono and polyclonal antibodies. When examining all 116 patients in both groups, both in the
group with spermatocele and epididymocele, there was an increase in the levels of pro- and anti-inflammatory cytokines:
tumor necrosis factor alpha, interleukin-4 and 6. Results of the study. The conducted scientific work is characterized by
a decrease in the level of cytokines, namely, the indicators of tumor necrosis factor alpha, interleukin - 4 and 6 in all examined
patients, after appropriate treatment with an anti-inflammatory drug - aceclofenac. Conclusion. Thus, the analysis
of the study showed that this method of conservative treatment with aceclofenac is highly effective, which positively affects
the outcome of the disease and the quality of life of the patient.

Chronic heart failure (CHF) and type 2 diabetes mellitus (DM) often coexist. CHF is currently considered as
a state of insulin resistance (IR) and is associated with a deterioration in the prognosis and quality of life of patients. The
beneficial effect of metformin on the course of cardiovascular diseases, CHF in particular, in patients with type 2 diabetes,
has been established in numerous studies. The aim of this study is to evaluate the effect of metformin on the clinical
course of ischemic etiology CHF in patients at the IR stage. Material and methods. In the course of an open, prospective,
randomized clinical trial of 76 patients with ischemic etiology CHF (mean age 62 (57.5-65) years, men (n=44), mean
left ventricular ejection fraction (LVEF) 44.0 % (34-52.5)), were randomized into 2 groups: with metformin (n=39) and
without (n=37), respectively. All patients were given and explained in detail the principles of lifestyle modification. IR
was diagnosed with HOMA-IR ≥ 2.5. The necessary objective (with a survey about the quality of life of patients with
CHF), laboratory and instrumental methods of research, a 6-minute walking test were tested at baseline and after 12
months of follow-up. Results. Metformin therapy was associated with an improvement in CHF-associated clinical indicators
such as : IR (HOMA-IR), aldosterone levels, functional capacity and quality of life. Also in the metformin group,
there was a significant improvement in renal function (in terms of creatinine and daily proteinuria) and mean LV EF.
Conclusion. The possibility of a favorable effect of metformin on the course of CHF of ischemic etiology in patients
without concomitant type 2 diabetes will optimize the strategy of interventions to improve the quality of life and longterm
prognosis in CHF, as well as reduce the rate of conversion to type 2 diabetes.

Atherosclerosis is currently considered one of the main problems of our century. It is predicted that by 2025,
the prevalence of cardiovascular diseases will reach 30% of the world's population [1]. Cardiovascular diseases are one
of the main causes of death. Every year, more than 17.5 million people die from cardiovascular pathology, in Kyrgyzstan
this figure reaches more than 18 thousand people. Due to the wide prevalence, high level of complications and mortality
rates, the prevention of cardiovascular diseases is becoming an increasingly priority area of medicine. Recently, the metabolic
direction has been intensively developed in medicine, the purpose of which is to analyze disorders of cellular metabolism
in cardiovascular pathologies. Impairment of function, which can lead to an increase in the permeability of
plasma components, especially low density lipoproteins and their deposition in the subendothelial space, can be considered
one of the earliest phenomena that occurs in atherosclerosis [2,3]. L-arginine, as a precursor of nitric oxide, has a positive
effect on the regulation of vascular tone and hemodynamics, is a mediator in the regulation of lipid and protein levels.
The effectiveness of the use of nitric oxide precursors during the development of a number of pathological conditions
(for example, endothelial dysfunction) has been proven. The study of the literature data of domestic and foreign authors
has shown that, to date, no experimental studies have been conducted in the Kyrgyz Republic to study the features of the
action of L-arginine in high altitude conditions, where special attention should be paid to the effectiveness of this amino
acid in such clinically extremely severe conditions as injuries, burns, hunger, stress.

The aim of the work is to study the clinical manifestations, results of laboratory and instrumental methods of
diagnosis in patients of Osh region of Kyrgyzstan infected with SARS-CoV-2, depending on the severity of the disease.
Research material and methods. A retrospective study was conducted among 71 patients who were tested positive(RTPCR)
according to The United Clinical Hospital of Osh, The City Hospital of Osh, Ministry of Health of the Kyrgyzstan.
Duration: April - December,2020.Demographics, clinical data, co-morbidity, laboratory results and chest CT interpretations
were analysed.
Results. Patients, infected with SARS-CoV-2,most likely to have thrombocytopenia (p<0.001), lymphopenia (p<0.001),
leukocytosis (p<0.01),high levels of D-dimer (p<0.01), elevated fibrinogen (p<0.05), high AST and ALT levels
(p<0.001)as the severity of the disease increases. In severe cases, the volume of lung tissue injury exceeds 50%, corresponding
to KT3 (n=11) and KT4 (n=14).The risk of severe SARS-CoV-2 infection increases in the older age group
(p<0.001), related to the presence of associated diseases: Essential Hypertension (51.6%), Coronary Artery disease
(35.3%), obesity (20.5%).Patients were treated in accordance with the Ministry of Health Clinical PractiseGuidelines .
Conclusion.The clinical and laboratory characteristics of COVID-19 patients in the Osh region of Kyrgyzstan have fluctuated
regularly depending on the severity of the disease.All of the patients that we had examined, including the patients
with severe features, improved during the treatment and were discharged.

Introduction. In the scientific work, the analysis of the results of the examination of 55 men who applied to
the Republican Scientific center of urology at the National hospital of the Ministry of Health of the Kyrgyz republic for
epididymal cyst. The circulation period falls on 2017-2021.
Purpose of the study. To evaluate the effectiveness of surgical treatment of patients with epididymal cyst using dissolving
preparations in the form of a solution of longidase (hyaluronidase) and sclerosant.
Materials and methods. The basis of this study included patients of reproductive age from 16 to 45 years, with a clinical
diagnosis of an epididymal cyst. The middle age of the examined patients was 33 ± 3 years. Complaints of patients upon
admission were taken into account. All men were examined by ultrasound. Ultrasound examination was performed using
the WED 9608 apparatus with a high-frequency probe and Doppler sonography. Testicular size, volume, shape, echogenicity,
and blood flow were assessed. Examined t a semen analysis. For all patients were performed surgical treatment according
to the author's method: "Method of combined treatment of cystic diseases of the epididymis", patent No. 2204.
Results of the study. The data on the condition of patients with an epididymal cyst before and after surgical treatment are
substantiated. A persistent positive trend was noted in the form of a decrease in pain symptoms in the postoperative
period, improvement of spermogram parameters in the form of quantitative and qualitative indicators as well as the absence
of infectious and inflammatory complications.
Conclusion. Thus, the analysis of the study showed that this method of surgical treatment is highly effective, which positively
affects the outcome of the disease and the quality of life of the patient.

Cryptorchidism is the cause of impaired spermatogenic and hormonal function [2,5], leading to infertility in
60% of men with unilateral, and 80% to 100% with a bilateral form of cryptorchidism [1,4]. The characteristics of patient
groups and the analysis of the effectiveness of the types of surgical interventions performed in 987 children with cryptorchidism
from 6 months to 16 years for the period from 2016 to 2021 are presented. The prevailing majority (78.4%)
are represented by patients older than 1 year (from 1 to 7 years), which confirms the fact of insufficient early detection
of cryptorchidism in the first year of life and is a contributing factor in the violation of germinative function. The predominance
of unilateral cryptorchidism (93.6%) over bilateral (6.4%), inguinal testicular location (94.4%) over the abdominal
location (5.6%) was noted by localization of the process. The technique of surgical treatment of childhood
cryptorchidism according to Torek-Gertzen is more traumatic and contributes to the development of postoperative infectious
complications 2.7 times more often, and unsatisfactory results are noted 3.5 times more often in comparison with
the Sokolov-Emelianov method. The introduction of laparoscopic methods of treatment is a priority direction of modern
surgery, allowing to improve the results of surgical treatment both in the early and in the long-term period in patients
with cryptorchidism.

The paper gives the clinical and epidemiological characteristics of secretory diarrhea in 242 young children
who received treatment at the Republican Clinical Infectious Diseases Hospital in Bishkek for the period 2016-2019. As
a result of the study, it was found that more often (64.0%) secretory diarrhea is observed in children of the first year of
life, less often (36.0%) in children older than 1 year. In almost every 2nd child, secretory diarrhea is caused by rotaviruses
(47.1%) and Escherichia (27.7%), less often (25.2%) other pathogens (norovirus, astrovirus, adenovirus, enterovirus,
proteus, klebsiella, etc.). The disease proceeded mainly (76.4%) in a severe form, especially in children of the first year
of life, with an unfavorable outcome in 1.2% of cases. The peak incidence of secretory diarrhea was noted in the winter
period, which is more typical for a viral infection. For the etiological interpretation of viral secretory diarrhea, an immunochromatographic
express test (57.7%) was used, and a study of feces for fecal calprotectin and lactoferrin was
carried out in order to exclude invasive intestinal infection. Determining the level of blood procalcitonin in secretory diarrhea
in young children shows the presence of a viral or bacterial infection in the patient. The use of these methods for
diagnosing secretory diarrhea will increase the level of etiological interpretation, differential diagnosis of diseases and
will help reduce the unreasonable use of antibacterial drugs, and prevent antibiotic-associated diarrhea.

This publication presents the results of a programm of the Mandatory Health Insurance Fund and the Ministry
of Health to introduce a new funding mechanism for hospital services provided to children during the first 24 hours of
hospitalisation. As an example, an assessment of the activities of the department of short-term stay of the Osh Interregional
Children's Clinical Hospital for the period 2016-2017 is presented. The opening of a short-stay unit has improved access
to medical care and has more than halved the time between admission and treatment. The introduction of the system of
providing short-term medical services has reduced the total number of unwarranted hospitalisations by 70% among therapeutic
and 50% among surgical patients in the inpatient departments of the Osh Interregional Children's Clinical Hospital,
with savings reaching 2,8005.0 thousand soms in 2017. The provision of 24-hour medical care in a short-stay unit has
increased the satisfaction of parents and carers with the services provided. The opening of a short-stay unit at a children's
hospital is an accessible, high-quality, promising, and cost-effective form of providing highly specialised medical care
to the pediatric population. The application of the practice of a one-day stays of the patient in the hospital had a beneficial
effect on the hospital budget. The activities carried out to indicate the need to increase the coverage of educational work
at the primary level in order to increase the sanitary and educational knowledge of the population.

The problem of echinococcosis is urgent, because the disease is quite common, at the same time the frequency
of diagnostic errors, complications and mortality in multiple echinococcosis is high. The aim of this work was to estimate
the clinical and epidemiological peculiarities of the liver and greater omentum echinococcosis, diagnostics of the disease
and results of treatment in the present conditions. A clinical case is presented, the patient R. 1976 patient was diagnosed
with hepatic echinococcosis and greater omentum, which was revealed spontaneously. On admission she was examined
additionally. Laparoscopic echinococcosisectomy of the liver and greater omentum was carried out. Intraoperatively the
diagnosis was confirmed. The patient was discharged home on the 5th day.

The review is devoted to the problem of weaning from mechanical ventilation (MV). Factors that prevent the
cessation of MV are considered. Criteria of the patient’s readiness for weaning from MV and conducting a spontaneous
breathing trial are given. Forced-auxiliary modes are a combination of forced and auxiliary ventilation. In these modes,
the hardware breaths are synchronized with the patient's attempt to inhale. In everyday clinical practice, the most commonly
used are: SIMV (synchronized intermittent (periodic) forced ventilation), P-SIMV (synchronized intermittent
forced ventilation with controlled pressure). The methods of weaning from MV, options of a spontaneous breathing trial
conduction and exercises to increase the strength and endurance of the respiratory muscles are described.

Introduction. Measles is an extremely contagious severe disease of viral origin. Before the introduction of the
measles vaccine in 1963 and the widespread vaccination, major measles epidemics occurred every 2-3 years, there were
2.6 million deaths from measles annually.
Research objectives. The objectives of this assessment are to describe the EPID surveillance system for measles and to
assess its properties, such as usefulness, timeliness, importance, simplicity.
Materials and methods of research. The assessment was carried out according to the instructions of the US Centers for
Disease Control and Prevention (CDC). To assess the epidemiological surveillance of measles, an epidemiological method
was used: the study of morbidity by territory among various population groups, in time and place.
Results. A sensitive, flexible and useful system of epidemiological surveillance of measles has been created and is functioning
in the Kyrgyz Republic, as it determines the trend of the epidemiological situation in the incidence of measles,
determines the outbreak. The evaluation by the criterion of importance showed that vaccination is 29 times more profitable
than the cost of treatment in terms of financial costs.
Conclusions. The analysis revealed problems in vaccination against measles. A detailed assessment of the root problems
of the 2019 measles outbreak should be carried out.

About 4 million cases of acute hepatitis B (AHB) are registered annually in the world, 7 million people are diagnosed
with chronic hepatitis B (CHB). More than 85% of those infected with hepatitis C virus (HCV) develop a chronic
form that leads to cirrhosis and primary liver cancer. Treatment at the present stage requires large economic costs and
long-term treatment. Chronic viral hepatitis (CVH) causes significant damage to public health due to its ubiquitous distribution
among various population groups, the variety of clinical forms and outcomes (including liver cirrhosis and primary
liver cancer). According to the data of long-term dynamics of morbidity since 2013, associated with CH in the
Kyrgyz Republic, it was predicted with the preservation of morbidity registration over the next decades. In the 8-year
dynamics (2013-2020), there is a tendency to reduce the incidence rate.Out of 155 cases of acute viral hepatitis, the cause
of infection was established in 79 cases (51%). An epidemiological investigation shows that in most cases the patient
cannot remember the likely routes of infection due to the long incubation period. And this is a problem in ascertaining
risk factors. Also, HBV diagnostics have not been established in healthcare facilities, which is confirmed by the large
number of carriers detected among medical workers (in 2020, carriers of HBV-179 cases, HCV-112 cases, detected for
the first time during a preventive examination), and the incidence among health workers is at a very low level (new detected
cases of HBV-0 and HCV-1 case, while CVH - 5 cases).Since parenteral viral hepatitis is still a common infection,
the incidence is still relevant today. Surveillance data for parenteral hepatitis in the Kyrgyz Republic are useful for monitoring, planning and detecting outbreaks.The article contains data on the evaluation of the existing HBV surveillance in
the Kyrgyz Republic. Recommendations are given describing the strengths and weaknesses of the system.

Introduction. IV infection causes progressive insufficiency of the immune system with an asymptomatic course,
subsequently leading to the development of secondary infections, various immunological disorders, as well as an increased
risk of developing various types of cancer, with the development of the terminal stage of AIDS. In 1996, the first registration
of HIV infection in a citizen of the Kyrgyz Republic took place. In the regions of the country, the registration of
HIV infection began in 1998. From September to December 2021, according to the instructions of the Centers for Disease
Control and Prevention of the USA, a simple epid assessment was carried out.supervision of HIV infection in the Kyrgyz
Republic. This article presents the results of the evaluation of the HIV surveillance system for 2018-2021, its strengths
and weaknesses. Based on the results of the evaluation, recommendations for improving the system are given.
The purpose of the study is to describe and evaluate the surveillance system for HIV infection in the Kyrgyz Republic,
using the properties of epidsuch as simplicity, sensitivity, flexibility.
Materials and methods. The data sources for the assessment were the documents of the AIDS centers. The analysis of all
reports, regulatory documents, clinical protocols, electronic tracking of HIV cases was carried out.
Results. The system is complex, there are many duplicate reporting forms, the sensitivity of the system is high, which
was 94.8%, the positive prognostic value was 47%, the system is timely, which can be assessed by the example of an increase
in adherence to ART by 15%.
Conclusions. The system is complicated by the number of reporting forms, of which there are 9, which can be circumvented
by entering the necessary reporting data immediately into an electronic database. The system showed high sensitivity
(94.8%), which is a very good indicator for surveillance, with early detection of an outbreak. Reports in the HIV
surveillance system in the Kyrgyz Republic are provided in a timely manner. The detection of new cases of HIV infection
is monitored daily, EPID is carried out at all levels of AIDS centers supervision.
Кыргызстандын Кемельбек к.Н., Карагулова А.Ш., Мергенова Г.А. саламаттык сактоо.

The laboratory service ensuring sanitary and epidemiological well-being in the public health system of the
Republic of Kazakhstan is designated to conduct qualitative various complexity levels research. This article presents the
results of the sanitary and epidemiological expertise organizations laboratory tests quality assurance study. The results
obtained indicate that the quality of laboratory studies performed is achieved by the proper organization of all interrelated
stages of work.

Introduction.Viral hepatitis B in the Kyrgyz Republic continues to be an urgent problem. The introduction of
routine immunization into the national vaccination schedule has undoubtedly made changes to the epidemic process of
viral hepatitis B at the present stage.
The purpose of the study- analysis of the epidemic process of viral hepatitis B at the present stage to assess the epidemiological
situation in the country.
Materials and methods. In the course of the work, epidemiological, statistical and serological research methods were
used.
Results and discussions.According to official statistics, the minimum intensive indicator was 1.5º/0000 in 2020; the maximum
was 38.9º/0000 in 2003. It should be noted that the incidence of hepatitis B tends to decrease. An analysis of the
age structure indicates the undoubted effectiveness of the ongoing immunoprophylaxis of the child population. The carriage
of HBsAg among young people is 7.1%, which indicates its significant spread in the population of our republic.
Conclusions.According to the epidemiological analysis, the incidence of viral hepatitis B in the population of the Kyrgyz
Republic decreased by 24.3 times. The incidence of the adult population has a stable trend with an average level of intensive
indicator of 9,7%.

The aging of the population is one of the most important demographic processes in the modern world, it is a
complex, multifactorial, medical and social problem. The trends of rapid aging of the population are mostly characteristic
of the whole planet, especially for low- and middle-income countries, where a threefold increase in the proportion of
people over 60 years of age is expected – 46 million (2015) to 147 million (2050). The manifestation of such patterns
can be predicted for the Kyrgyz Republic, where people over 50 increased from 12.0% in 1999 to 16% in 2019. The
highest proportion of elderly people goes to the citizens of the capital from 14.7% to 17.9%, respectively. Moreover, all
these processes are accompanied by a significant increase in the life expectancy of Kyrgyzstanis, averaging from 67.0 to
71.5 years in the country and from 68.4 to 74.6 years in Bishkek, respectively. Against this background, practically in the
modern system of healthcare and social welfare of the Kyrgyz state there is no personnel potential and organizations to
provide gerontological care to the population. Consequently, in order to respond more effectively to the aging of the population,
the public health system needs an approach that will prevent and reverse the decline in the functional ability and
their dependency on outside help in old age. It is necessary to implement such an approach as soon as possible for the
country's state institutions to create favorable conditions for the elderly with an improved mechanism for monitoring the
demographic situation and its forecasting for the next three decades.

A wide variety of diseases associated with low vitamin D levels are being supported by a growing body of research.
Data are now available on the endocrine, autocrine, and paracrine activities of vitamin D and on the major determinants
of vitamin D decline in humans. Vitamin D deficiency leads to comorbidity, impaired functioning of the human
body, which has its own characteristics depending on age.

Introduction. The coronavirus pandemic (COVID-19) originated in China and affected almost the entire world
in early 2020. To understand and inform about effective public health measures, we conducted a survey of knowledge,
attitudes and practices among the adult population of the cities of Bishkek and Naryn, the Kyrgyz Republic.
Research methods. In August 2021, a cross-sectional study was conducted with a survey of the adult population of the
cities of Bishkek and Naryn, the Kyrgyz Republic. A simple two-stage cluster sampling method was used to recruit study
participants. The analysis was carried out using the statistical software Epi Info 7. The variables were summarized as
frequency and percentage.
Results. The survey was conducted among the adult population of Bishkek 1,390 (86%) and Naryn 234 (14%). A total of
1,624 questionnaires were analyzed, the response rate was 95%, of which 918 (57%) were men and 706 (43%) were
women. The average age of the study participants was 35 years, the standard deviation was 14.9. 1490 (92%) of respondents
knew that COVID-19 can spread from person to person when people are in close contact, 1371 (84%) knew that a
person infected with COVID-19 can transmit the virus to others, not even symptoms. 1446 (89) noted that it is important
to wear a mask, but only 1255 (77) respondents wear a mask, 1440 (89) noted that it is important to observe physical distance
indoors, however, only 955 (59) of the respondents surveyed observe it, 1556 (96) said that it is important to wash
their hands after visiting public places.

Introduction. Despite coronavirus disease (COVID-19) mitigation measures implemented in Kyrgyzstan hospitals,
3,173 healthcare workers (HCW) had been diagnosed with COVID-19 by September 2020, amounting to 17% of
all COVID-19 cases. We aimed to identify risks for COVID-19 among HCW exposed to COVID-19 patients in Bishkek.
Methods. We conducted a nested case-control study of HCW in six hospitals with high COVID-19 incidence among
HCW using incidence-density sampling. HCW in the national COVID-19 registry with SARS-CoV-2 PCR-positive and
SARS-CoV-2 IgG-negative results June 2020-May 2021 were recruited as cases if exposed to COVID-19 patients <14
days. Controls were randomly selected among HCW concurrently working at the same hospitals with SARS-CoV-2 PCRand
IgG-negative results. We collected sociodemographic, work, clinical, and laboratory information, and used logistic
regression to identify factors significantly (p<0.05) associated with COVID-19.
Results. A total of 511 people were included in the study, of which 128 cases and 383 controls. Out of 511 participants:
454 (89%) women and 383 (75%) participants under the age of 50. Of the participants, 118 (92%) cases and 348 (91%)
controls lived in a hostel (not at home) during the shift. Comorbidities were noted in 44 (34%) cases and 56 (15%)controls. According to the results of the analysis, testing for the tightness of the respirator, sharing a hostel for shift work
with other medical workers and the presence of comorbidities served as risk factors for the disease.
Conclusions. Results suggest need for increased quality assurance of and training in correct fitting and donning of personal
protective equipment, especially respirators, and improved communication for HCW promoting personal responsibility
in protecting staff, patients, and themselves.

The occurrence of stroke in patients with COVID-19 infection is relatively rare, but COVID-19 is an important
prognostic marker and indicator of severity. This brief review suggests that ischemic stroke may occur early in the disease
and may also affects patients in younger age groups without comorbidities, causing large vessel occlusion and exhibiting
thrombo-inflammatory neuroimaging. The mechanisms underlying the development of stroke in patients with COVID-
19 may be associated both with the usual factors of increased risk of stroke, traditionally found in patients without COVID-
19, and with the development of coagulopathy induced by infection against the background of a systemic inflammatory
reaction characteristic for coronavirus infection.

The creation and development of hygienic science in the system of higher medical education of the country is
connected with the opening of the Kyrgyz Medical Institute in 1939 and the organization of the Department of General
Hygiene. Subsequently, the historiography of hygiene is closely interrelated with the opening in 1953 of the sanitary and
hygienic faculty with specialized departments, forming a comprehensive development of preventive medicine in the
country. The process under consideration of the experience of accumulating the development of science in various areas
of hygiene covers a long road from the 38-40s of the XX century to the present period of the XXI century, the achievements
of scientists-hygienists of Kyrgyzstan. The presented analysis allows us to conclude that the study of various issues
of the development of hygienic disciplines was a kind of center of organizational foundations for conducting scientific
research in the field of hygiene. Today in the modern world, hygiene as a science and practice is undergoing qualitative
changes, which significantly actualizes the study of historiographical aspects of its development in the Kyrgyz Republic.