2023

In order to coordinate the interaction of state bodies to ensure the sanitary and epidemiological well-being and biological safety of the population of the EAEU member states, the heads of state decided to create a permanent subsidiary body of the Union - the "Council of Heads of Authorized Bodies in the field of sanitary and epidemiological welfare of the population of the member States". It includes the heads of authorized bodies in the field of sanitary and epidemiological welfare of the population (chief state sanitary doctors) of the member States of the Union and representatives of the
Eurasian Economic Commission. The Leadership Council has become a platform for discussing the experience of Member States and international experience, as well as the formation of effective mechanisms for the implementation of a coordinated or coordinated policy on the application of sanitary measures. During the COVID-19 coronavirus pandemic, this Council proved to be a really functioning body in combating the spread
and minimizing the consequences of the spread of COVID-19.
A number of regulatory and advisory acts of the Union were adopted, which made it possible to respond to challenges in a timely manner, contributed to the speedy restoration of uninterrupted cross-border supply of essential goods to the Member States, including disinfection products, medicines, medical and non-medical products, and initiated joint research
to assess post-vaccination and post-infectious population immunity to the SARS-CoV-2 and the study of variations of coronavirus strains, It made it possible to consistently move towards lifting the imposed restrictions and resuming the free movement of citizens of the Member States across the territory of the Union as soon as possible, contributed to the
effective implementation of joint activities and the adoption of necessary management decisions to prevent and minimize the consequences of the spread of COVID-19 coronavirus infection. The authorized body of the Kyrgyz Republic also took an active part in this work, in particular, it prepared and adopted "Sanitary and epidemiological recommendations regulating an agreed algorithm for responding to outbreaks of infectious
diseases (Recommendation of the Board of the Commission No. 12 of April 5, 2022)". The functioning of the Council of Heads has shown the effectiveness and necessity of the work of this body to solve urgent problems related to common challenges to the health of the population of the Member States of the Union.

The organization of the Eurasian Economic Union (EAEU) created 7 years ago in order to strengthen the economies of the member states, provided effective levers within the framework of public health, allowing to ensure the sanitary and epidemiological well-being of the population by reducing the risk of import and circulation of dangerous products, the spread of infectious and mass non communicable diseases (poisoning). The creation of the EAEU allowed
the sanitary and epidemiological services of the member states to effectively use their human resources, research potential, be on guard of public health and solve one of the most important state tasks - ensuring the sanitary and epidemiological
well-being of the population of the member states. The work carried out by the Eurasian Economic Commission (EEC) - the permanent supranational regulatory body of the EAEU and by the authorized state bodies of the member states on the sanitary and epidemiological well-being of the population within the framework of integration processes and the contractual and legal framework in the field of sanitary
measures, and regulations adopted on their basis, make it possible to ensure effective control and an appropriate level of safety in the field of sanitary measures. It ensures the prompt exchange of information on identified dangerous products
between the authorized bodies of the Member States, promotes the removal of barriers to the movement of goods when applying sanitary and phytosanitary (SPS) measures, establishes general principles and approaches to determining responsibility for violations of acts in the field of sanitary measures. The ongoing work leads to the actualization of sanitary-epidemiological and hygienic requirements for product safety on the basis of scientific research, including the analysis of the risk of harmful effects on the human body of environmental factors, as well as the implementation of a risk-based surveillance model in the field of product safety for human health. The adoption of methodological documents and recommendations in the EEC is carried out on the basis of the results of scientific research, taking into account the principles laid down in the agreements of the World Trade Organization (WTO) and the standards of the Codex Alimentarius Commission. All this and the further development of integration processes in the field of sanitary measures within the EAEU, allows the Kyrgyz Republic to be on modern, advanced positions in the application of SPS measures and the preservation of the health and life of each person and society as a whole.

Introduction. Infection control of tuberculosis is an urgent problem in the health care system today. The basis of infection control is early and prompt diagnosis and proper treatment of TB patients. TB infection control is a system of organizational, anti-epidemic and preventive measures aimed at preventing the nosocomial spread of TB among patients and staff.[2] It is particularly relevant to primary health care (PHC) health care organization. According to the WHO, 90% of annual new cases occur in 30 countries with a heavy burden of tuberculosis.[1] Preventing the spread of infection is one of the main objectives of both infection control and epidemiology in general. The likelihood of infecting healthy people in contact with patients with active tuberculosis is very high. Therefore, it is important that all health care workers
know how to properly triage suspected sources of infection and quickly perform the tests necessary for diagnosis, identify a pulmonary TB patient in time, and refer him to a tuberculosis dispensary (PTD) for treatment. The objective of this review was to provide an evidence-based rationale for TB infection control in primary health care
(PHC) facilities. Methods and Materials. We performed a literature review of tuberculosis legal and regulatory documents covering the territory of the Kyrgyz Republic and a literature review of scientific papers using resources of PubMed, Google Academia and eLIBRARY search engines. Results and their discussion. In general, it should be noted that the TB infection control system introduced in the health care organizations of the Kyrgyz Republic has not proven itself badly in specialized TB hospitals, while in general hospitals and primary health care facilities there are significant shortcomings in the implementation of IC measures. It should
also be noted that the probability of infecting healthy people in contact with active TB patients is very high. Therefore, it is important that all health workers know how to properly triage suspected sources of infection and quickly conduct the necessary tests for diagnosis, timely identify a patient with pulmonary tuberculosis and refer him to a TB dispensary for treatment. To do this, service delivery processes should be organized at the primary care level. Conclusion. Proper placement and organization of triage, diagnosis, and treatment facilities for suspected persons with active tuberculosis significantly reduce the risk of infection.

Introduction. The COVID-19 pandemic resulted in a significant increase in the burden on health care workers
and demonstrated a dangerous disregard for their health, safety, and well-being. Health care workers had a critical rolenot only in the clinical management of patients, but also in ensuring appropriate infection prevention and infection control (IPIC) measures in health care organizations. "Preventive measures taken in the Kyrgyz Republic in response to the COVID-19 pandemic, including the introduction
of the State of Emergency (SOE) and border closures, were not effective, and the epidemic spread to all regions, with high rates of infection among and healthcare workers of alarming concern. One in four cases occurred among health workers (26%)." [13] And this rate among health workers remained high.
The aim of the study was to study and analyze literature-scientific data on the fact of high COVID-19 infection among medical workers and on necessity, relevance of organization of epidemiological surveillance of COVID-19 spread among medical workers, as an effective measure of COVID-19 prevention in the general population. Methods. We studied and analyzed 13 literature-scientific data that were identified during the global epidemiological surveillance of WHO, Rospotrebnadzor of the Russian Federation and data of epidemiological investigation of causeeffect relationships of COVID-19 infection of medical workers in Kyrgyzstan until May 2020. The results of the information-analytical search, allowed to substantiate the relevance and priority for the Kyrgyz Republic in the organization of epidemiological surveillance over the spread of COVID-19 among health workers, which is essential and relevant to the scientific validity in the organization of epidemiological surveillance over the spread of COVID-19 among health workers in DHD of the Kyrgyz Republic by assessing the potential risk factors of infection of health workers with SARS-CoV-2 virus, as to identify the characteristics of transmission, i.e. Conclusion. National level scientific studies to assess the epidemiological situation of COVID-19 among health care workers, including their exposure characteristics and risk factors, as part of a case-control study, will be directed for epidemiological
surveillance purposes and to obtain an epidemiological picture. The results of which will help us determine
the most appropriate CRP measures at the level of health care organizations.

The results of the innovative pilot project for kit development for hepatitis E serum-diagnostic assays of the Interstate Program for Innovative Cooperation of the CIS member states for the period up to 2020 are presented. The project was carried out by I.I. Mechnikov Federal State Medical Research Institute for Vaccines and Sera in association with the National Institute of Public Health of the Ministry of Health of the Kyrgyz Republic and Belarusian medical and veterinary research institutions. As a result of research recombinant antigens of the prevalent in the CIS countries HEV genotypes 1 and 3 were developed, and a set of diagnostic assays was made, namely: test for quantification of IgG antibodies to HEV, test for determination the avidity of IgG antibodies to HEV, test for measuring the total antibodies to HEV, test for detection IgM antibodies to HEV, test for detection HEV antigen, confirmation test for detection antibodies to HEV by linear immune assay, immune-chromatographic rapid test for detection the antibodies to HEV and a high-precision test for detection HEV RNA in sera and plasma by PCR. The results of serum epidemiological and molecular epidemiological studies performed in the regions of Russia, Kyrgyzstan and Belarus indicated a consistent increase proportion of hepatitis E in the structure of acute hepatitis cases in these countries with the avoidance of a large number of the cases from diagnosis and registration.

Introduction. Cervical cancer is one of the most frequent diseases in oncogynecology and continues to occupy the first place among the causes of female mortality from malignant neoplasms. The aim of the study - The purpose of this systematic review is to assess the completeness and significance of recent studies on cervical cancer for public health and scientific achievements, with the identification of areas that require further detailed study. Materials and methods. The review and data of modern literature on the diagnosis, treatment and prevention of cervical cancer are presented, with a summary of the key points of medical monitoring of patients with this disease. Results. The recommendations of researchers in recent years are presented, which can help oncogynecologists develop individual management tactics for each specific patient with cervical cancer and improve the quality of life of patients. Conclusions. Planning diagnostic and therapeutic measures in patients with background and precancerous diseases of the cervix continues to be an urgent task, the solution of which will increase the effectiveness of cervical cancer prevention.

Arterial hypertension (AH) is the main modifiable risk factor for the development of cardiovascular (CV) complications. Despite the widespread prevalence of hypertension in the world (about 1.4 billion people), its detectability among the population remains low. Despite serious CV and cerebral complications, hypertension is called a "silent killer", as it has been asymptomatic for a long time. In the absence of symptoms, people have no motivation to undergo an examination for the presence of high blood pressure (HBP) and receive hypotensive treatment. Even with the detection of hypertension and the availability of a large number of effective antihypertensive drugs, the number of patients with uncontrolled hypertension continues to grow, especially in low- and moderate-income countries. Only 14% of them have blood pressure controlled during treatment. Poor blood pressure control is associated with poor patient adherence to treatment and, as a result, a large number of cerebral and CV complications are observed. To improve adherence to treatment and, accordingly, blood pressure control, leading professional associations have suggested starting treatment immediately with two antihypertensive drugs of different classes in one tablet.
Combination therapy with antihypertensive drugs of different classes has a greater antihypertensive effect than doubling the dose with monotherapy, while reducing the number of side effects. As an initial double antihypertensive therapy, a combination of ace inhibitors or Angiotensin-II-receptor antagonists (sartans) is recommended + Calcium channel blockers (CCBs) or ACE inhibitors or sartans + diuretics, and the combination of ACE inhibitors or sartans + CCBs is considered preferable. And given that ACE inhibitors cause more side effects, it is possible to start treatment immediately with a combination of s CCBs + Sartan (amlodipine + valsartan). With such therapy, the antihypertensive effect is enhanced due to additive synergism, as well as increased adherence to treatment, as the number of tablets taken decreases.

The pandemic caused by COVID-19 has affected many areas of our lives, and we are still analyzing and systematizing its consequences. Post-COVID syndrome is a global threat to humans. Our task is to understand the mechanisms of development of these symptoms in order to develop effective preventive and therapeutic recommendations for preventing the development of post-COVID syndrome.