Кыргызстандын Саламаттык Сактоо
Zdravoohraneniye Kyrgyzstana

ISSN 1694-8068 (Print)

ISSN 1694-805X (Online)

Кирүү

Кош бойлуу аялдарда В гепатит вирусунун вертикалдык жугушунун коркунуч факторлору жана алдын алуу ыкмаларынын натыйжалуулугу

https://dx.doi.org/10.51350/zdravkg2025.4.12.9.73.79
Кош бойлуу аялдарда В гепатит вирусунун вертикалдык жугушунун коркунуч факторлору жана алдын алуу ыкмаларынын натыйжалуулугу
Полный текст Full text  

PDF (RUS)

PDF (RUS)
Корутунду Авторлор жөнүндө Шилтемелер

Корутунду

Киришүү. В гепатит вирусунун вертикалдык жугушу перинаталдык медицинанын актуалдуу көйгөйү бойдон калууда, анткени ал баланын өнөкөт HBV-инфекцияга чалдыгуу коркунучун аныктайт. Изилдөөнүн максаты. В гепатит вирусунун вертикалдык жугушунун негизги коркунуч факторлорун аныктоо жана жаңы төрөлгөн ымыркайлардын жугушун алдын алуунун ар кандай схемаларынын натыйжалуулугун баалоо. Материалдар жана ыкмалар. Өнөкөт HBV-инфекциясы бар 231 кош бойлуу аялдын маалыматтарына ретроспективдүү талдоо жүргүзүлдү. Серологиялык, молекулярдык-биологиялык жана лабораториялык көрсөткүчтөр, анын ичинде APRI индекси бааланды. Статистикалык иштетүү χ² критерийи жана Манн–Уитни тестинин жардамы менен жүргүзүлдү. Натыйжалар жана талкуу. APRI индексинин жогорулашы (p < 0,0001) кош бойлуу аялдарда жаңы төрөлгөн балдардын HBsAg-оң статусунун негизги коркунуч фактору катары аныкталып, вертикалдык жугушту божомолдоодо боор фиброзун баалоонун маанисин көрсөттү. Айкалышкан профилактика (вакцинация + HBIG) инфекциядан толук коргоону камсыз кылган, ал эми жалгыз вакцинация учурунда балдардын 13,1 %ында HBsAg аныкталган (p = 0,009). Вертикалдык жугуш өнөкөт инфекциянын бардык стадияларында, анын ичинде виремиясы төмөн (< 200 000 МЕ/мл) болгон HBeAg-терс формаларында да мүмкүн экендиги аныкталды. Вакцинация менен айкалышкан тенофовирди (TDF) эрте дайындоо вирус жугушун натыйжалуу алдын алып, HBIG колдонулган схемаларга альтернатива боло алат. Жыйынтык. Антивирустук терапияны жана спецификалык иммунопрофилактиканы айкалыштыруу HBVнин вертикалдык жугушунун коркунучун төмөндөтүүнүн эң натыйжалуу стратегиясы болуп саналат.

Авторлор жөнүндө

Турсунбаева Мира Сабирбековна, ассистент кафедры инфекционных болезней Международной высшей школы медицины, Бишкек, Кыргызская Республика

Tursunbaeva Mira Sabirbekovna, Assistant, Department of Infectious Diseases, International Higher School of Medicine, Bishkek, Kyrgyz Republic

Турсунбаева Мира Сабирбековна, Эл аралык жогорку медицина мектебинин жугуштуу оорулар кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы

Шилтемелер

1. World Health Organization. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis
in pregnancy. Geneva: WHO; 2020. https://www.who.int/publications/i/item/978-92-4-000270-8
2. Tran TT, Ahn J, Reau NS. Treatment and prevention of viral hepatitis in pregnancy. Clin Liver Dis. 2021;25(2):237–254.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8907340
3. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: Management of chronic hepatitis
B virus infection. J Hepatol. 2023;79(1):S1–S33. https://www.journal-of-hepatology.eu/article/S0168-8278(23)00181-2/fulltext
4. Zhang J, et al. A scoping review of hepatitis B guidelines to reduce mother-to-child transmission. Lancet Reg Health West Pac.
2025;43:100772. https://pmc.ncbi.nlm.nih.gov/articles/PMC11772972
5. World Health Organization. Hepatitis B vaccines: WHO position paper. Wkly Epidemiol Rec. 2017;92(27):369–392.
https://www.who.int/publications/i/item/WER9227
6. Zhou YH, Hu Y, Liu X, Yang H; CSOG MFM Committee. CSOG MFM Committee Guideline: Management of Hepatitis B
During Pregnancy and Prevention of Mother-to-Child Transmission of Hepatitis B Virus (2020). Maternal Fetal Med. 2021;3(1):7–
17. https://journals.lww.com/mfm/fulltext/2021/01000/csog_mfm_committee_guideline__management_of.3.aspx
7. World Health Organization. WHO Guidelines on hepatitis B and C testing and antiviral prophylaxis in pregnancy. Geneva: WHO;
2021. https://www.ncbi.nlm.nih.gov/books/NBK561126
8. Wai CT, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis B.

Hepatology. 2003;38(2):518–526. https://pubmed.ncbi.nlm.nih.gov/12883497
9. Johnson PJ, et al. Assessment of liver function in patients with hepatocellular carcinoma: ALBI grade and score. J Clin Oncol.
2015;33(6):550–558. https://pubmed.ncbi.nlm.nih.gov/25512453
10. Wiseman E, et al. Perinatal transmission of hepatitis B virus: risk and prevention. J Hepatol. 2009;51(3):513–528. https://pub
med.ncbi.nlm.nih.gov/19560225
11. Pan CQ, et al. Tenofovir to prevent hepatitis B transmission in mothers with high viral load. N Engl J Med. 2016;374(24):2324–
2334. https://www.nejm.org/doi/full/10.1056/NEJMoa1508660
12. Liu J, et al. Maternal hepatic inflammation and risk of perinatal transmission of hepatitis B virus. Clin Infect Dis. 2020;71(3):681–689. https://pubmed.ncbi.nlm.nih.gov/31426260

1. World Health Organization. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis
in pregnancy. Geneva: WHO; 2020. https://www.who.int/publications/i/item/978-92-4-000270-8
2. Tran TT, Ahn J, Reau NS. Treatment and prevention of viral hepatitis in pregnancy. Clin Liver Dis. 2021;25(2):237–254.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8907340
3. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: Management of chronic hepatitis
B virus infection. J Hepatol. 2023;79(1):S1–S33. https://www.journal-of-hepatology.eu/article/S0168-8278(23)00181-2/fulltext
4. Zhang J, et al. A scoping review of hepatitis B guidelines to reduce mother-to-child transmission. Lancet Reg Health West Pac.
2025;43:100772. https://pmc.ncbi.nlm.nih.gov/articles/PMC11772972
5. World Health Organization. Hepatitis B vaccines: WHO position paper. Wkly Epidemiol Rec. 2017;92(27):369–392.
https://www.who.int/publications/i/item/WER9227
6. Zhou YH, Hu Y, Liu X, Yang H; CSOG MFM Committee. CSOG MFM Committee Guideline: Management of Hepatitis B
During Pregnancy and Prevention of Mother-to-Child Transmission of Hepatitis B Virus (2020). Maternal Fetal Med. 2021;3(1):7–
17. https://journals.lww.com/mfm/fulltext/2021/01000/csog_mfm_committee_guideline__management_of.3.aspx
7. World Health Organization. WHO Guidelines on hepatitis B and C testing and antiviral prophylaxis in pregnancy. Geneva: WHO;
2021. https://www.ncbi.nlm.nih.gov/books/NBK561126
8. Wai CT, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis B.

Hepatology. 2003;38(2):518–526. https://pubmed.ncbi.nlm.nih.gov/12883497
9. Johnson PJ, et al. Assessment of liver function in patients with hepatocellular carcinoma: ALBI grade and score. J Clin Oncol.
2015;33(6):550–558. https://pubmed.ncbi.nlm.nih.gov/25512453
10. Wiseman E, et al. Perinatal transmission of hepatitis B virus: risk and prevention. J Hepatol. 2009;51(3):513–528. https://pub
med.ncbi.nlm.nih.gov/19560225
11. Pan CQ, et al. Tenofovir to prevent hepatitis B transmission in mothers with high viral load. N Engl J Med. 2016;374(24):2324–
2334. https://www.nejm.org/doi/full/10.1056/NEJMoa1508660
12. Liu J, et al. Maternal hepatic inflammation and risk of perinatal transmission of hepatitis B virus. Clin Infect Dis. 2020;71(3):681–689. https://pubmed.ncbi.nlm.nih.gov/31426260

1. World Health Organization. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis
in pregnancy. Geneva: WHO; 2020. https://www.who.int/publications/i/item/978-92-4-000270-8
2. Tran TT, Ahn J, Reau NS. Treatment and prevention of viral hepatitis in pregnancy. Clin Liver Dis. 2021;25(2):237–254.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8907340
3. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: Management of chronic hepatitis
B virus infection. J Hepatol. 2023;79(1):S1–S33. https://www.journal-of-hepatology.eu/article/S0168-8278(23)00181-2/fulltext
4. Zhang J, et al. A scoping review of hepatitis B guidelines to reduce mother-to-child transmission. Lancet Reg Health West Pac.
2025;43:100772. https://pmc.ncbi.nlm.nih.gov/articles/PMC11772972
5. World Health Organization. Hepatitis B vaccines: WHO position paper. Wkly Epidemiol Rec. 2017;92(27):369–392.
https://www.who.int/publications/i/item/WER9227
6. Zhou YH, Hu Y, Liu X, Yang H; CSOG MFM Committee. CSOG MFM Committee Guideline: Management of Hepatitis B
During Pregnancy and Prevention of Mother-to-Child Transmission of Hepatitis B Virus (2020). Maternal Fetal Med. 2021;3(1):7–
17. https://journals.lww.com/mfm/fulltext/2021/01000/csog_mfm_committee_guideline__management_of.3.aspx
7. World Health Organization. WHO Guidelines on hepatitis B and C testing and antiviral prophylaxis in pregnancy. Geneva: WHO;
2021. https://www.ncbi.nlm.nih.gov/books/NBK561126
8. Wai CT, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis B.

Hepatology. 2003;38(2):518–526. https://pubmed.ncbi.nlm.nih.gov/12883497
9. Johnson PJ, et al. Assessment of liver function in patients with hepatocellular carcinoma: ALBI grade and score. J Clin Oncol.
2015;33(6):550–558. https://pubmed.ncbi.nlm.nih.gov/25512453
10. Wiseman E, et al. Perinatal transmission of hepatitis B virus: risk and prevention. J Hepatol. 2009;51(3):513–528. https://pub
med.ncbi.nlm.nih.gov/19560225
11. Pan CQ, et al. Tenofovir to prevent hepatitis B transmission in mothers with high viral load. N Engl J Med. 2016;374(24):2324–
2334. https://www.nejm.org/doi/full/10.1056/NEJMoa1508660
12. Liu J, et al. Maternal hepatic inflammation and risk of perinatal transmission of hepatitis B virus. Clin Infect Dis. 2020;71(3):681–689. https://pubmed.ncbi.nlm.nih.gov/31426260

Негизги сөздөр
Кош бойлуулук , Алдын алуу , вирустук гепатит В (ВГВ) , Вертикалдык жугуу , APRI , HBIG , Тенофовир
Для цитирования

Турсунбаева М.С. Факторы риска вертикальной передачи вируса гепатита B и эффективность различных схем профилактики у беременных.Научно-практический журнал«Здравоохранение Кыргызс- тана» 2025, № 4, с. 73-79. https://dx.doi.org/10.51350/zdravkg2025.4.12.9.73.79
For citation
Tursunbaeva M.S. Risk factors for vertical transmission of HBV infection and strategies for its prevention. Scientific practical journal “Health care of Kyrzstan” 2025, No.4, p. 73-79. https://dx.doi.org/10.51350/zdravkg2025.4.12.9.73.79
Цитата үчүн

Турсунбаева М.С. Кош бойлуу аялдарда В гепатит вирусунун вертикалдык жугушунун коркунуч факторлору жана алдын алуу ыкмаларынын натыйжалуулугу. "Кыргызстандын саламаттык сактоо" илимий-практикалык журналы
2025, № 4, б. 73-79. https://dx.doi.org/10.51350/zdravkg2025.4.12.9.73.79
Авторлор Турсунбаева М.С.
Ссылка doi.org https://dx.doi.org/10.51350/zdravkg2025.4.12.9.73.79
Беттер 73-79
Негизги сөздөр Кош бойлуулук, Алдын алуу, вирустук гепатит В (ВГВ), Вертикалдык жугуу, APRI, HBIG, Тенофовир
Орусча
Об авторах

Турсунбаева Мира Сабирбековна, ассистент кафедры инфекционных болезней Международной высшей школы медицины, Бишкек, Кыргызская Республика

Полный текст

PDF (RUS)
Список литературы

1. World Health Organization. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis
in pregnancy. Geneva: WHO; 2020. https://www.who.int/publications/i/item/978-92-4-000270-8
2. Tran TT, Ahn J, Reau NS. Treatment and prevention of viral hepatitis in pregnancy. Clin Liver Dis. 2021;25(2):237–254.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8907340
3. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: Management of chronic hepatitis
B virus infection. J Hepatol. 2023;79(1):S1–S33. https://www.journal-of-hepatology.eu/article/S0168-8278(23)00181-2/fulltext
4. Zhang J, et al. A scoping review of hepatitis B guidelines to reduce mother-to-child transmission. Lancet Reg Health West Pac.
2025;43:100772. https://pmc.ncbi.nlm.nih.gov/articles/PMC11772972
5. World Health Organization. Hepatitis B vaccines: WHO position paper. Wkly Epidemiol Rec. 2017;92(27):369–392.
https://www.who.int/publications/i/item/WER9227
6. Zhou YH, Hu Y, Liu X, Yang H; CSOG MFM Committee. CSOG MFM Committee Guideline: Management of Hepatitis B
During Pregnancy and Prevention of Mother-to-Child Transmission of Hepatitis B Virus (2020). Maternal Fetal Med. 2021;3(1):7–
17. https://journals.lww.com/mfm/fulltext/2021/01000/csog_mfm_committee_guideline__management_of.3.aspx
7. World Health Organization. WHO Guidelines on hepatitis B and C testing and antiviral prophylaxis in pregnancy. Geneva: WHO;
2021. https://www.ncbi.nlm.nih.gov/books/NBK561126
8. Wai CT, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis B.

Hepatology. 2003;38(2):518–526. https://pubmed.ncbi.nlm.nih.gov/12883497
9. Johnson PJ, et al. Assessment of liver function in patients with hepatocellular carcinoma: ALBI grade and score. J Clin Oncol.
2015;33(6):550–558. https://pubmed.ncbi.nlm.nih.gov/25512453
10. Wiseman E, et al. Perinatal transmission of hepatitis B virus: risk and prevention. J Hepatol. 2009;51(3):513–528. https://pub
med.ncbi.nlm.nih.gov/19560225
11. Pan CQ, et al. Tenofovir to prevent hepatitis B transmission in mothers with high viral load. N Engl J Med. 2016;374(24):2324–
2334. https://www.nejm.org/doi/full/10.1056/NEJMoa1508660
12. Liu J, et al. Maternal hepatic inflammation and risk of perinatal transmission of hepatitis B virus. Clin Infect Dis. 2020;71(3):681–689. https://pubmed.ncbi.nlm.nih.gov/31426260
Для цитирования

Турсунбаева М.С. Факторы риска вертикальной передачи вируса гепатита B и эффективность различных схем профилактики у беременных.Научно-практический журнал«Здравоохранение Кыргызс- тана» 2025, № 4, с. 73-79. https://dx.doi.org/10.51350/zdravkg2025.4.12.9.73.79
Англисче
About authors

Tursunbaeva Mira Sabirbekovna, Assistant, Department of Infectious Diseases, International Higher School of Medicine, Bishkek, Kyrgyz Republic
Full text

PDF (RUS)
References

1. World Health Organization. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis
in pregnancy. Geneva: WHO; 2020. https://www.who.int/publications/i/item/978-92-4-000270-8
2. Tran TT, Ahn J, Reau NS. Treatment and prevention of viral hepatitis in pregnancy. Clin Liver Dis. 2021;25(2):237–254.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8907340
3. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: Management of chronic hepatitis
B virus infection. J Hepatol. 2023;79(1):S1–S33. https://www.journal-of-hepatology.eu/article/S0168-8278(23)00181-2/fulltext
4. Zhang J, et al. A scoping review of hepatitis B guidelines to reduce mother-to-child transmission. Lancet Reg Health West Pac.
2025;43:100772. https://pmc.ncbi.nlm.nih.gov/articles/PMC11772972
5. World Health Organization. Hepatitis B vaccines: WHO position paper. Wkly Epidemiol Rec. 2017;92(27):369–392.
https://www.who.int/publications/i/item/WER9227
6. Zhou YH, Hu Y, Liu X, Yang H; CSOG MFM Committee. CSOG MFM Committee Guideline: Management of Hepatitis B
During Pregnancy and Prevention of Mother-to-Child Transmission of Hepatitis B Virus (2020). Maternal Fetal Med. 2021;3(1):7–
17. https://journals.lww.com/mfm/fulltext/2021/01000/csog_mfm_committee_guideline__management_of.3.aspx
7. World Health Organization. WHO Guidelines on hepatitis B and C testing and antiviral prophylaxis in pregnancy. Geneva: WHO;
2021. https://www.ncbi.nlm.nih.gov/books/NBK561126
8. Wai CT, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis B.

Hepatology. 2003;38(2):518–526. https://pubmed.ncbi.nlm.nih.gov/12883497
9. Johnson PJ, et al. Assessment of liver function in patients with hepatocellular carcinoma: ALBI grade and score. J Clin Oncol.
2015;33(6):550–558. https://pubmed.ncbi.nlm.nih.gov/25512453
10. Wiseman E, et al. Perinatal transmission of hepatitis B virus: risk and prevention. J Hepatol. 2009;51(3):513–528. https://pub
med.ncbi.nlm.nih.gov/19560225
11. Pan CQ, et al. Tenofovir to prevent hepatitis B transmission in mothers with high viral load. N Engl J Med. 2016;374(24):2324–
2334. https://www.nejm.org/doi/full/10.1056/NEJMoa1508660
12. Liu J, et al. Maternal hepatic inflammation and risk of perinatal transmission of hepatitis B virus. Clin Infect Dis. 2020;71(3):681–689. https://pubmed.ncbi.nlm.nih.gov/31426260
For citation
Tursunbaeva M.S. Risk factors for vertical transmission of HBV infection and strategies for its prevention. Scientific practical journal “Health care of Kyrzstan” 2025, No.4, p. 73-79. https://dx.doi.org/10.51350/zdravkg2025.4.12.9.73.79
Кыргызча
Авторлор жөнүндө

Турсунбаева Мира Сабирбековна, Эл аралык жогорку медицина мектебинин жугуштуу оорулар кафедрасынын ассистенти, Бишкек, Кыргыз Республикасы
Шилтемелер

1. World Health Organization. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis
in pregnancy. Geneva: WHO; 2020. https://www.who.int/publications/i/item/978-92-4-000270-8
2. Tran TT, Ahn J, Reau NS. Treatment and prevention of viral hepatitis in pregnancy. Clin Liver Dis. 2021;25(2):237–254.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8907340
3. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: Management of chronic hepatitis
B virus infection. J Hepatol. 2023;79(1):S1–S33. https://www.journal-of-hepatology.eu/article/S0168-8278(23)00181-2/fulltext
4. Zhang J, et al. A scoping review of hepatitis B guidelines to reduce mother-to-child transmission. Lancet Reg Health West Pac.
2025;43:100772. https://pmc.ncbi.nlm.nih.gov/articles/PMC11772972
5. World Health Organization. Hepatitis B vaccines: WHO position paper. Wkly Epidemiol Rec. 2017;92(27):369–392.
https://www.who.int/publications/i/item/WER9227
6. Zhou YH, Hu Y, Liu X, Yang H; CSOG MFM Committee. CSOG MFM Committee Guideline: Management of Hepatitis B
During Pregnancy and Prevention of Mother-to-Child Transmission of Hepatitis B Virus (2020). Maternal Fetal Med. 2021;3(1):7–
17. https://journals.lww.com/mfm/fulltext/2021/01000/csog_mfm_committee_guideline__management_of.3.aspx
7. World Health Organization. WHO Guidelines on hepatitis B and C testing and antiviral prophylaxis in pregnancy. Geneva: WHO;
2021. https://www.ncbi.nlm.nih.gov/books/NBK561126
8. Wai CT, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis B.

Hepatology. 2003;38(2):518–526. https://pubmed.ncbi.nlm.nih.gov/12883497
9. Johnson PJ, et al. Assessment of liver function in patients with hepatocellular carcinoma: ALBI grade and score. J Clin Oncol.
2015;33(6):550–558. https://pubmed.ncbi.nlm.nih.gov/25512453
10. Wiseman E, et al. Perinatal transmission of hepatitis B virus: risk and prevention. J Hepatol. 2009;51(3):513–528. https://pub
med.ncbi.nlm.nih.gov/19560225
11. Pan CQ, et al. Tenofovir to prevent hepatitis B transmission in mothers with high viral load. N Engl J Med. 2016;374(24):2324–
2334. https://www.nejm.org/doi/full/10.1056/NEJMoa1508660
12. Liu J, et al. Maternal hepatic inflammation and risk of perinatal transmission of hepatitis B virus. Clin Infect Dis. 2020;71(3):681–689. https://pubmed.ncbi.nlm.nih.gov/31426260
Цитата үчүн

Турсунбаева М.С. Кош бойлуу аялдарда В гепатит вирусунун вертикалдык жугушунун коркунуч факторлору жана алдын алуу ыкмаларынын натыйжалуулугу. "Кыргызстандын саламаттык сактоо" илимий-практикалык журналы
2025, № 4, б. 73-79. https://dx.doi.org/10.51350/zdravkg2025.4.12.9.73.79
Көрүүлөр: 97
Copyright MAXXmarketing GmbH
JoomShopping Download & Support